Travel options for:
Knoxville to Chicago
  • Fly to Chicago O'Hare

    $209 - $492
    1. Knoxville

      18 min - 12.4 miles

      $55 - $70

    2. Knoxville (TYS)

      1 h 46 min - non-stop

      $150 - $420

    3. Chicago O'Hare (ORD)

      42 min - every 10 minutes

      $2 - $5

  • Fly to Chicago Midway

    $199 - $821
    1. Knoxville

      18 min - 12.4 miles

      $55 - $70

    2. Knoxville (TYS)

      3 h 50 min - 1 stopover

      $140 - $750

    3. Chicago Midway (MDW)

      24 min - every 15 minutes

      $2 - $4

  • Megabus, bus

    $67 - $92
    1. Knoxville

      2 h - once daily

      $12 - $22

    2. Chattanooga

      12 h 15 min - twice daily

      $55 - $70

  • Bus, train via Louisville, KY

    $106 - $236
    1. Knoxville, TN

      3 h 45 min - once daily

      $23 - $60

    2. Lexington, KY

      1 h 40 min - once daily

      $24 - $35

    3. Louisville, KY

      2 h 15 min - once daily

      $18 - $45

    4. Indianapolis Amtrak

      5 h - 4 times a week

      $40 - $100

  • Bus, train

    $90 - $208
    1. Knoxville, TN

      5 h 32 min - once daily

      $30 - $75

    2. Cincinnati, OH

      3 h 13 min - once daily

      $18 - $35

    3. Indianapolis Amtrak

      5 h - 4 times a week

      $40 - $100

  • Bus

    $115 - $195
    1. Knoxville, TN

      3 h 45 min - once daily

      $23 - $60

    2. Lexington, KY

      1 h 40 min - once daily

      $24 - $35

    3. Louisville, KY

      8 h 15 min - once daily

      $50 - $80

    4. Hammond, IN

      45 min - once daily - line 0358

      $17 - $24

  • Drive

    $50 - $80
    1. Knoxville

      8 h 56 min - 541.8 miles

      $50 - $80

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From Knoxville taxi to Knoxville airport, fly to Chicago O'Hare airport, then subway to Chicago. 2 h 50 min $282. From Knoxville taxi to Knoxville airport, fly to Chicago Midway airport, then subway to Chicago. 4 h 37 min $461. From Knoxville Megabus to Chattanooga then bus to Chicago. 15 h 15 min $78. From Knoxville, TN bus to Lexington, KY, bus to Louisville, KY, bus to Indianapolis Amtrak, then train to Chicago Union Station Amtrak. 15 h 40 min $170. From Knoxville, TN bus to Cincinnati, OH, bus to Indianapolis Amtrak, then train to Chicago Union Station Amtrak. 15 h 45 min $152. From Knoxville, TN bus to Lexington, KY, bus to Louisville, KY, bus to Hammond, IN, then line 0358 bus to Chicago, IL. 17 h 25 min $146. From Knoxville drive to Chicago. 8 h 56 min $64.