There are 6 ways to get from Knoxville to Chicago by plane, bus, train or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly to Chicago O'Hare  •  2 h 54 min

  1. Fly from Knoxville (TYS) to Chicago O'Hare (ORD) TYS - ORD

$209 - $492

Cheapest option

Bus  •  12 h 34 min

  1. Take the bus from Knoxville, Tn to Cincinnati, Oh 1104 / ...
  2. Take the bus from Cincinnati, Oh to Chicago, Il 4970

$60 - $151

4 alternative options

Fly to Chicago Midway  •  4 h 54 min

  1. Fly from Knoxville (TYS) to Chicago Midway (MDW) TYS - MDW

$199 - $821

Megabus, bus  •  15 h 15 min

  1. Take the Megabus from Knoxville to Chattanooga via Philadelphia
  2. Take the bus from Chattanooga to Chicago

$67 - $92

Bus, train  •  15 h 49 min

  1. Take the bus from Knoxville, Tn to Lexington, Ky
  2. Take the bus from Lexington, Ky to Cincinnati, Oh
  3. Take the bus from Cincinnati, OH to Indianapolis, IN
  4. Take the train from Indianapolis Amtrak to Chicago Union Station Amtrak

$94 - $223

Drive  •  8 h 55 min

  1. Drive from Knoxville to Chicago 540.7 miles

$50 - $80

Questions & Answers

The cheapest way to get from Knoxville to Chicago is to drive which costs $50 - $80 and takes 8 h 55 min.

More details

The quickest way to get from Knoxville to Chicago is to fly which takes 2 h 54 min and costs $200 - $500.

More details

The distance between Knoxville and Chicago is 732 km. The road distance is 865 km.

Get driving directions

It takes approximately 2 h 54 min to get from Knoxville to Chicago, including transfers.

More details

No, there is no direct bus from Knoxville to Chicago. However, there are services departing from Knoxville, Tn and arriving at Chicago, Il via Cincinnati, Oh. The journey, including transfers, takes approximately 12 h 34 min.

More details

What companies run services between Knoxville, TN, USA and Chicago, IL, USA?

United Airlines, American Airlines and Delta fly from Knoxville to Chicago hourly. Alternatively, you can take a bus from Knoxville to Chicago via Cincinnati, Oh in around 12 h 34 min.

Airlines
Delta
Website
delta.com
Flights from Knoxville to Chicago O'Hare via Atlanta
Ave. Duration
4 h 11 min
When
Every day
Estimated price
$340 - $850
Flights from Knoxville to Chicago O'Hare via Detroit
Ave. Duration
4 h 4 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$340 - $850
Flights from Knoxville to Chicago Midway via Detroit
Ave. Duration
4 h 50 min
When
Every day
Estimated price
$140 - $750
Flights from Knoxville to Chicago Midway via Atlanta
Ave. Duration
4 h 24 min
When
Every day
Estimated price
$140 - $750
Flights from Knoxville to Chicago Midway via Minneapolis
Ave. Duration
7 h 48 min
When
Every day
Estimated price
$170 - $800
American Airlines
Website
aa.com
Flights from Knoxville to Chicago O'Hare
Ave. Duration
1 h 55 min
When
Every day
Estimated price
$330 - $750
Flights from Knoxville to Chicago O'Hare via Charlotte
Ave. Duration
4 h 20 min
When
Every day
Estimated price
$330 - $750
United Airlines
Website
united.com
Flights from Knoxville to Chicago O'Hare
Ave. Duration
1 h 53 min
When
Every day
Estimated price
$300 - $750
Train operators
Amtrak
Phone
+1 1-800-872-7245
Website
amtrak.com
Train from Indianapolis Amtrak to Chicago Union Station Amtrak
Ave. Duration
5 h
Frequency
Twice daily
Estimated price
$40 - $100
Website
amtrak.com
Coach Seat
$40 - $60
Flexi Coach Seat
$70 - $110
Business Coach Seat
$70 - $100
Room
$200 - $280
Bus operators
Greyhound USA
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from Knoxville, Tn to Cincinnati, Oh
Ave. Duration
5 h 24 min
Frequency
Every 30 minutes
Estimated price
$29 - $75
Website
greyhound.com
Economy
$29 - $50
Flexible
$55 - $75
Bus from Cincinnati, Oh to Chicago, Il
Ave. Duration
6 h 10 min
Frequency
Every 2 hours
Estimated price
$30 - $80
Website
greyhound.com
Economy
$30 - $55
Flexible
$60 - $80
Bus from Knoxville, Tn to Lexington, Ky
Ave. Duration
3 h 49 min
Frequency
Every 30 minutes
Estimated price
$22 - $55
Website
greyhound.com
Economy
$22 - $35
Flexible
$40 - $55
Bus from Lexington, Ky to Cincinnati, Oh
Ave. Duration
1 h 25 min
Frequency
Every 30 minutes
Estimated price
$14 - $35
Website
greyhound.com
Economy
$14 - $21
Flexible
$25 - $35
Megabus
Phone
877-462-6342
Website
us.megabus.com
Bus from Knoxville to Chattanooga
Ave. Duration
2 h
Frequency
3 times a day
Estimated price
$12 - $22
Schedules at
us.megabus.com
Bus from Chattanooga to Chicago
Ave. Duration
12 h 15 min
Frequency
Twice daily
Estimated price
$55 - $70
Schedules at
us.megabus.com

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