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There are 6 ways to get from Knoxville to Chicago by plane, bus, train or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly to Chicago O'Hare  •  2 h 58 min

  1. Fly from Knoxville (TYS) to Chicago O'Hare (ORD) TYS - ORD

$209 - $492

Cheapest option

Bus  •  12 h 34 min

  1. Take the bus from Knoxville, Tn to Cincinnati, Oh 1104 / ...
  2. Take the bus from Cincinnati, Oh to Chicago, Il 4970

$60 - $151

4 alternative options

Fly to Chicago Midway  •  4 h 47 min

  1. Fly from Knoxville (TYS) to Chicago Midway (MDW) TYS - MDW

$199 - $821

Bus, train  •  15 h 21 min

  1. Take the bus from Knoxville, Tn to Cincinnati, Oh
  2. Take the bus from University of Cincinnati to Indianapolis, IN
  3. Take the train from Indianapolis Amtrak Station to Chicago Union Station

$83 - $196

Bus Hoosier Ride  •  15 h 54 min

  1. Take the bus from Knoxville, Tn to Lexington, Ky
  2. Take the bus from Lexington, KY to Louisville, KY
  3. Take the bus from Louisville, KY to Chicago, IL

$99 - $243

Drive  •  8 h 55 min

  1. Drive from Knoxville to Chicago 540.7 miles

$50 - $80

Questions & Answers

The cheapest way to get from Knoxville to Chicago is to drive which costs $50 - $80 and takes 8 h 55 min.

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The quickest way to get from Knoxville to Chicago is to fly which costs $200 - $500 and takes 2 h 58 min.

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No, there is no direct bus from Knoxville to Chicago. However, there are services departing from Knoxville, Tn and arriving at Chicago, Il via Cincinnati, Oh. The journey, including transfers, takes approximately 12 h 34 min.

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The distance between Knoxville and Chicago is 457 miles. The road distance is 540.7 miles.

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The best way to get from Knoxville to Chicago without a car is to bus which takes 12 h 34 min and costs $60 - $160.

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It takes approximately 2 h 58 min to get from Knoxville to Chicago, including transfers.

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Knoxville to Chicago bus services, operated by Greyhound USA, depart from Knoxville, Tn station.

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The best way to get from Knoxville to Chicago is to fly which takes 2 h 58 min and costs $200 - $500. Alternatively, you can bus, which costs $60 - $160 and takes 12 h 34 min.

Mode details

The quickest flight from Knoxville Airport to Chicago O'Hare Airport is the direct flight which takes 1 h 52 min.

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Knoxville to Chicago bus services, operated by Greyhound USA, arrive at Chicago, Il station.

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Map of how to get from Knoxville to Chicago.
Launch map view
  • Distance: 457.2 miles
  • Duration: 2 h 58 min

What companies run services between Knoxville, TN, USA and Chicago, IL, USA?

American Airlines, United Airlines and Delta fly from Knoxville to Chicago hourly. Alternatively, you can take a bus from Knoxville to Chicago via Cincinnati, Oh in around 12 h 34 min.

Airlines
Delta
Website
delta.com
Flights from Knoxville to Chicago O'Hare via Atlanta
Ave. Duration
4 h 17 min
When
Every day
Estimated price
$340 - $850
Flights from Knoxville to Chicago Midway via Atlanta
Ave. Duration
4 h 33 min
When
Every day
Estimated price
$140 - $750
Flights from Knoxville to Chicago Midway via Detroit
Ave. Duration
5 h 3 min
When
Every day
Estimated price
$140 - $750
Flights from Knoxville to Chicago Midway via Minneapolis
Ave. Duration
8 h 4 min
When
Sunday
Estimated price
$170 - $800
American Airlines
Website
aa.com
Flights from Knoxville to Chicago O'Hare
Ave. Duration
1 h 55 min
When
Every day
Estimated price
$330 - $750
Flights from Knoxville to Chicago O'Hare via Charlotte
Ave. Duration
4 h 18 min
When
Monday to Friday
Estimated price
$330 - $750
United Airlines
Website
united.com
Flights from Knoxville to Chicago O'Hare
Ave. Duration
1 h 57 min
When
Every day
Estimated price
$300 - $750
Train operators
Amtrak

Amtrak is a rail service that connects the US and three Canadian provinces. Covering 21,000 route miles (34,000km) Amtrak operates more than 300 trains daily. These medium and long distance intercity services operate at speeds of up to 240km/h, to more than 500 destinations. Founded in 1971, it is based in Washington, D.C. and offers four classes of travel: First Class, Sleeper, Business and Coach. Ticket fares are divided into five subclasses: Saver, Value, Flexible, Business and Premium. Amtrak trains are known for their wide seats, plug-in power, big windows and storage capabilities.

Rome2rio's guide to Amtrak
Contact Details
Phone
+1 215-856-7924
Website
amtrak.com
Train from Indianapolis Amtrak Station to Chicago Union Station
Ave. Duration
5 h
Frequency
Once daily
Estimated price
$40 - $100
Website
amtrak.com
Coach Seat
$40 - $60
Flexi Coach Seat
$70 - $110
Business Coach Seat
$70 - $100
Room
$200 - $280
Bus operators
Greyhound USA

Greyhound is a leading bus company based in Dallas, Texas, serving over 3800 destinations across North America, Mexico and Canada. Greyhound carries around 18 million passengers a year who travel 5.4 billion miles (8.6 billion km) a year on their fleet of around 1700 vehicles. For travel flexibility, you can board or get off a Greyhound bus at official Greyhound stations, partner stations and curbside stops. There are around 230 Greyhound stations across the US where you can both catch your bus and buy tickets, that are also available on the official website and via the mobile app.

Rome2rio's guide to Greyhound USA
Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from Knoxville, Tn to Cincinnati, Oh
Ave. Duration
5 h 24 min
Frequency
4 times a day
Estimated price
$29 - $75
Website
greyhound.com
Economy
$29 - $50
Flexible
$55 - $75
Bus from Cincinnati, Oh to Chicago, Il
Ave. Duration
6 h 10 min
Frequency
Once daily
Estimated price
$30 - $80
Website
greyhound.com
Economy
$30 - $55
Flexible
$60 - $80
Bus from Knoxville, Tn to Lexington, Ky
Ave. Duration
3 h 49 min
Frequency
4 times a day
Estimated price
$22 - $55
Website
greyhound.com
Economy
$22 - $35
Flexible
$40 - $55
Megabus
Hoosier Ride
Phone
800-544-2383
Website
hoosierride.com
Bus from Lexington, KY to Louisville, KY
Ave. Duration
1 h 20 min
Frequency
4 times a day
Estimated price
$21 - $100
Book at
hoosierride.com
Bus from Louisville, KY to Chicago, IL
Ave. Duration
8 h 45 min
Frequency
Once daily
Estimated price
$55 - $90
Book at
hoosierride.com

Want to know more about travelling around United States

Rome2rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

More Questions & Answers

Chicago is 1 h behind Knoxville. It is currently 8:11 AM in Knoxville and 7:11 AM in Chicago.

Yes, the driving distance between Knoxville to Chicago is 541 miles. It takes approximately 8 h 55 min to drive from Knoxville to Chicago.

Get driving directions

United Airlines, American Airlines and Delta offer flights from Knoxville Airport to Chicago O'Hare Airport.

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Book your Knoxville to Chicago bus tickets online with Greyhound and Greyhound.

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There are 607+ hotels available in Chicago. Prices start at $88 USD per night.

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The best way to get from Knoxville to Knoxville Airport is to taxi which takes 18 min and costs $55 - $70.

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