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How to get fromKnoxville to Appletonby plane, bus (Greyhound, Flixbus), car, bus, train, or bus (Flixbus)

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There are 7 ways to get from Knoxville to Appleton by plane, bus (Greyhound, Flixbus), car, bus, train, or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Appleton International Airport

    best
    1. Fly from Mcghee Tyson Airport (TYS) to Appleton International Airport (ATW)plane plane TYS - ATW
    4h 30m
    $241–1,035

  2. Drive 715.9 mi

    cheapest
    1. Drive from Knoxville to Appletoncar car 715.9 mi
    12h 40m
    $131–189

  3. Bus

    1. Take the bus from Knoxville to Nashvillebus bus Nyc
    2. Take the bus from Nashville Bus Station to Chicago Bus Stationbus bus
    3. Take the bus from Chicago Bus Station to Appleton Transit Centerbus bus
    20h 24m
    $232–359

  4. Fly to Green Bay

    1. Fly from Mcghee Tyson Airport (TYS) to Green Bay (GRB)plane plane TYS - GRB
    6h 6m
    $187–660

  5. Fly to General Mitchell International Airport, bus

    1. Fly from Mcghee Tyson Airport (TYS) to General Mitchell International Airport (MKE)plane plane TYS - MKE
    2. Take the bus from Milwaukee Airport to Appletonbus bus
    7h 52m
    $204–845

  6. Bus, train

    1. Take the bus from Knoxville to Nashvillebus bus Nyc
    2. Take the bus from Nashville Bus Station to Chicago Bus Stationbus bus
    3. Take the train from Chicago Union Station to Milwaukeetrain train
    4. Take the bus from Milwaukee to Appletonbus bus
    21h 3m
    $246–391

  7. Bus via Memphis

    1. Take the bus from Knoxville to Jacksonbus bus Nyc
    2. Take the bus from El Mezcal Grocery - Jackson, TN to Tornado Bus Co - West Memphisbus bus
    3. Take the bus from Tornado Bus Co - West Memphis to Water & Chicago - Circle Kbus bus
    4. Take the bus from Milwaukee to Appletonbus bus
    24h 43m
    $295–577

Mcghee Tyson Airport (TYS) to Appleton International Airport (ATW) flights

Calendar84Weekly Planes
Duration5h 27mAverage Duration
Ticket$178Cheapest Price
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Questions & Answers

Map of how to get from Knoxville to Appleton.ExpandLaunch map view
  • Distance: 648.4 mi
  • Duration: 4h 30m

What companies run services between Knoxville, TN, USA and Appleton, WI, USA?

Delta, American Airlines, and United Airlines fly from Mcghee Tyson Airport (TYS) to Appleton International Airport (ATW) every 2 hours. Alternatively, you can take a vehicle from Knoxville to Appleton Transit Center via Knoxville, Nashville, Charlotte Pike & Lellyett St Eb, Central 5Th Ave - Bay 1, Central 4Th Ave - Bay 13, Fulton Station Outbound, Nashville Bus Station, and Chicago Bus Station in around 20h 24m.

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