There are 4 ways to get from Kirksville to Chicago by train, car or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Train  •  5 h 37 min

  1. Take the train from La Plata Amtrak to Chicago Union Station Amtrak Southwest Chief

$83 - $179

3 alternative options

Drive  •  6 h 50 min

  1. Drive from Kirksville to Chicago 398 miles

$35 - $60

Fly Kirksville to Chicago Midway  •  3 h 42 min

  1. Fly from Kirksville (IRK) to Chicago Midway (MDW) IRK - MDW

$108 - $409

Train, train to Burlington, fly to Chicago O'Hare  •  7 h 49 min

  1. Take the train from La Plata Amtrak to Galesburg Amtrak
  2. Take the train from Galesburg Amtrak to Burlington Amtrak
  3. Fly from Burlington (BRL) to Chicago O'Hare (ORD) BRL - ORD

$151 - $246

What companies run services between Kirksville, MO, USA and Chicago, IL, USA?

Amtrak operates a train from Kirksville to Chicago twice daily. Tickets cost $50 - $140 and the journey takes 5 h 20 min. Alternatively, Cape Air, Southwest Airlines and Delta fly from Kirksville to Chicago every 4 hours.

Airlines
Southwest Airlines
Website
southwest.com
Flights from Kirksville to Chicago Midway via St. Louis
Ave. Duration
4 h 10 min
When
Every day
Estimated price
$85 - $380
Flights from Kirksville to Chicago Midway via St. Louis, Columbus
Ave. Duration
6 h 10 min
When
Sunday
Estimated price
$100 - $430
Flights from Kirksville to Chicago Midway via St. Louis, Kansas City
Ave. Duration
6 h 50 min
When
Monday to Friday
Estimated price
$100 - $430
Flights from Kirksville to Chicago Midway via St. Louis, Pittsburgh
Ave. Duration
6 h 50 min
When
Sunday
Estimated price
$120 - $460
Air Choice One
Website
airchoiceone.com
Flights from Burlington to Chicago O'Hare
Ave. Duration
1 h 40 min
When
Every day
Estimated price
$50 - $120
Delta
Website
delta.com
Flights from Kirksville to Chicago Midway via St. Louis, Detroit
Ave. Duration
6 h 44 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$90 - $440
Train operators
Amtrak
Phone
+1 1-800-872-7245
Website
amtrak.com
Train from La Plata Amtrak to Chicago Union Station Amtrak
Ave. Duration
5 h 20 min
Frequency
Twice daily
Estimated price
$50 - $140
Website
amtrak.com
Coach Seat
$50 - $80
Flexi Coach Seat
$90 - $140
Business Coach Seat
$95 - $140
Room
$240 - $330
Train from La Plata Amtrak to Galesburg Amtrak
Ave. Duration
2 h 13 min
Frequency
Twice daily
Estimated price
$30 - $80
Website
amtrak.com
Coach Seat
$30 - $50
Flexi Coach Seat
$60 - $85
Business Coach Seat
$55 - $80
Room
$170 - $240
Train from Galesburg Amtrak to Burlington Amtrak
Ave. Duration
47 min
Frequency
Once daily
Estimated price
$23 - $45
Website
amtrak.com
Coach Seat
$23 - $35
Flexi Coach Seat
$40 - $60
Business Coach Seat
$30 - $45
Room
$130 - $190

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Questions & Answers

How far is it from Kirksville to Chicago?

The distance between Kirksville and Chicago is 456 km. The road distance is 637 km.

What is the cheapest way to get from Kirksville to Chicago?

The cheapest way to get from Kirksville to Chicago is to drive which costs $35 - $60 and takes 6 h 50 min.

What is the fastest way to get from Kirksville to Chicago?

The quickest way to get from Kirksville to Chicago is to fly which takes 3 h 42 min and costs $100 - $410.

How long does it take to get from Kirksville to Chicago?

It takes approximately 5 h 37 min to get from Kirksville to Chicago, including transfers.