There are 4 ways to get from Kirksville to Chicago by train, car or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Train  •  5 h 34 min

  1. Take the train from La Plata Amtrak to Chicago Union Station Amtrak Southwest Chief

$83 - $179

3 alternative options

Drive  •  6 h 50 min

  1. Drive from Kirksville to Chicago 398 miles

$35 - $60

Fly Kirksville to Chicago Midway  •  3 h 57 min

  1. Fly from Kirksville (IRK) to Chicago Midway (MDW) IRK - MDW

$108 - $409

Train, train to Burlington, fly to Chicago O'Hare  •  7 h 51 min

  1. Take the train from La Plata Amtrak to Galesburg Amtrak
  2. Take the train from Galesburg Amtrak to Burlington Amtrak
  3. Fly from Burlington (BRL) to Chicago O'Hare (ORD) BRL - ORD

$151 - $246

Questions & Answers

The cheapest way to get from Kirksville to Chicago is to drive which costs $35 - $60 and takes 6 h 50 min.

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The quickest way to get from Kirksville to Chicago is to fly which costs $100 - $410 and takes 3 h 57 min.

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The distance between Kirksville and Chicago is 285 miles. The road distance is 398 miles.

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The best way to get from Kirksville to Chicago without a car is to train which takes 5 h 34 min and costs $80 - $180.

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It takes approximately 5 h 34 min to get from Kirksville to Chicago, including transfers.

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The best way to get from Kirksville to Chicago is to train which takes 5 h 34 min and costs $80 - $180. Alternatively, you can fly, which costs $100 - $410 and takes 3 h 57 min.

Mode details

There is no direct flight from Kirksville Airport to Chicago Midway Airport. The quickest flight takes 9 h 10 min and has one stopover.

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Yes, the driving distance between Kirksville to Chicago is 398 miles. It takes approximately 6 h 50 min to drive from Kirksville to Chicago.

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Delta, Cape Air and Southwest Airlines offer flights from Kirksville Airport to Chicago Midway Airport.

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The nearest airport to Chicago is Chicago Midway (MDW) Airport which is 8.5 miles away. Other nearby airports include Chicago O'Hare (ORD) (16 miles), Milwaukee (MKE) (75.8 miles) and Madison (MSN) (124.2 miles).

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Map of how to get from Kirksville to Chicago.
Launch map view
  • Distance: 284.8 miles
  • Duration: 5 h 34 min

What companies run services between Kirksville, MO, USA and Chicago, IL, USA?

Amtrak operates a train from Kirksville to Chicago twice daily. Tickets cost $50 - $140 and the journey takes 5 h 17 min. Alternatively, Cape Air, Southwest Airlines and two other airlines fly from Kirksville to Chicago every 3 hours.

Airlines
Southwest Airlines
Website
southwest.com
Flights from Kirksville to Chicago Midway via St. Louis
Ave. Duration
4 h
When
Every day
Estimated price
$85 - $380
Flights from Kirksville to Chicago Midway via St. Louis, Kansas City
Ave. Duration
6 h 2 min
When
Monday to Saturday
Estimated price
$100 - $430
Flights from Kirksville to Chicago Midway via St. Louis, Nashville
Ave. Duration
6 h
When
Monday to Friday
Estimated price
$100 - $430
Flights from Kirksville to Chicago Midway via St. Louis, Omaha
Ave. Duration
6 h 5 min
When
Sunday
Estimated price
$110 - $440
Flights from Kirksville to Chicago Midway via St. Louis, Cleveland
Ave. Duration
6 h 20 min
When
Sunday
Estimated price
$110 - $450
Flights from Kirksville to Chicago Midway via St. Louis, Raleigh/Durham
Ave. Duration
6 h 35 min
When
Sunday
Estimated price
$130 - $500
Flights from Kirksville to Chicago Midway via St. Louis, Dallas
Ave. Duration
7 h 10 min
When
Sunday
Estimated price
$130 - $550
Air Choice One
Website
airchoiceone.com
Flights from Burlington to Chicago O'Hare
Ave. Duration
1 h 40 min
When
Every day
Estimated price
$50 - $120
Delta
Website
delta.com
Flights from Kirksville to Chicago Midway via St. Louis, Detroit
Ave. Duration
6 h 40 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$90 - $440
Train operators
Amtrak
Rome2rio's guide to Amtrak
Contact Details
Phone
+1 1-800-872-7245
Website
amtrak.com
Train from La Plata Amtrak to Chicago Union Station Amtrak
Ave. Duration
5 h 17 min
Frequency
Twice daily
Estimated price
$50 - $140
Website
amtrak.com
Coach Seat
$50 - $80
Flexi Coach Seat
$90 - $140
Business Coach Seat
$95 - $140
Room
$240 - $330
Train from La Plata Amtrak to Galesburg Amtrak
Ave. Duration
2 h 15 min
Frequency
Twice daily
Estimated price
$30 - $80
Website
amtrak.com
Coach Seat
$30 - $50
Flexi Coach Seat
$60 - $85
Business Coach Seat
$55 - $80
Room
$170 - $240
Train from Galesburg Amtrak to Burlington Amtrak
Ave. Duration
47 min
Frequency
Once daily
Estimated price
$23 - $45
Website
amtrak.com
Coach Seat
$23 - $35
Flexi Coach Seat
$40 - $60
Business Coach Seat
$30 - $45
Room
$130 - $190

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