There are 4 ways to get from Key West to St. Louis by plane, bus (Greyhound, Flixbus), or car
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly to Lambert–St. Louis International Airport
best- Fly from Key West International Airport (EYW) to Lambert–St. Louis International Airport (STL)plane EYW - STL
5h 37m$185–867Fly to Midamerica St. Louis Airport
cheapest- Fly from Key West International Airport (EYW) to Midamerica St. Louis Airport (BLV)plane EYW - BLV
17h 10m$138–596Bus
- Take the bus from N Roosevelt & 3rd Street to Big Pine Key - Auto Store / NAPA MM30bus Lks
- Take the bus from Big Pine Key to Miami Airport Stationbus
- Take the bus from Miami Airport Station to Atlanta Bus Stationbus
- Take the bus from Atlanta Bus Station to St Louis Bus Stationbus
34h 16m$140–419Drive 1,352.3 mi
- Drive from Key West to St. Louiscar 1,352.3 mi
23h 47m$247–357
Key West to St. Louis by bus and foot
Questions & Answers
The cheapest way to get from Key West to St. Louis is to bus which costs $140 - $420 and takes 34h 16m.
The fastest way to get from Key West to St. Louis is to fly which takes 5h 37m and costs $180 - $900.
No, there is no direct bus from Key West to St. Louis station. However, there are services departing from N Roosevelt & 3rd Street and arriving at St Louis Bus Station via Big Pine Key, Miami Airport Station and Atlanta Bus Station. The journey, including transfers, takes approximately 34h 16m.
The distance between Key West and St. Louis is 1125 miles. The road distance is 1360.2 miles.
The best way to get from Key West to St. Louis without a car is to bus which takes 34h 16m and costs $140 - $420.
It takes approximately 5h 37m to get from Key West to St. Louis, including transfers.
Key West to St. Louis bus services, operated by Key West Transit, depart from N Roosevelt & 3rd Street station.
The best way to get from Key West to St. Louis is to fly which takes 5h 37m and costs $180 - $900. Alternatively, you can bus, which costs $140 - $420 and takes 34h 16m.
Key West to St. Louis bus services, operated by Key West Transit, arrive at Big Pine Key - Auto Store / NAPA MM30 station.
St. Louis is 1h behind Key West. It is currently 2:26 PM in Key West and 1:26 PM in St. Louis.
What companies run services between Key West, FL, USA and St. Louis, MO, USA?
American Airlines and Delta fly from Key West International Airport (EYW) to Lambert–St. Louis International Airport (STL) every 3 hours. Alternatively, you can take a bus from N Roosevelt & 3rd Street to St Louis Bus Station via Big Pine Key - Auto Store / NAPA MM30, Big Pine Key, Miami Airport Station, and Atlanta Bus Station in around 34h 16m.
- Website
- aa.com
Flights from Key West International Airport to Lambert–St. Louis International Airport via Miami
- Ave. Duration
- 5h 19m
- When
- Every day
- Estimated price
- $180–900
Flights from Key West International Airport to Lambert–St. Louis International Airport via Charlotte
- Ave. Duration
- 6h 52m
- When
- Every day
- Estimated price
- $190–950
- Website
- delta.com
Flights from Key West International Airport to Lambert–St. Louis International Airport via Atlanta
- Ave. Duration
- 5h 53m
- When
- Every day
- Estimated price
- $170–850
- Website
- allegiantair.com
Flights from Key West International Airport to Midamerica St. Louis Airport via St. Petersburg
- Ave. Duration
- 15h 55m
- When
- Thursday and Sunday
- Estimated price
- $100–550
- Phone
- +1 305-809-3700
- Website
- cityofkeywest-fl.gov
Bus from N Roosevelt & 3rd Street to Big Pine Key - Auto Store / NAPA MM30
- Ave. Duration
- 54 min
- Frequency
- Every 3 hours
- Estimated price
- $2–4
- Schedules at
- https://www.cityofkeywest-fl.gov/595/Schedules-and-Route-Maps
Rome2Rio's guide to Greyhound USA
Contact Details
- Phone
- +1 214-849-8100
- ifsr@greyhound.com
- Website
- greyhound.com
Bus from Big Pine Key to Miami Airport Station
- Ave. Duration
- 3h 35m
- Frequency
- 3 times a day
- Estimated price
- $23–55
- Website
- https://www.greyhound.com/
Bus from Miami Airport Station to Atlanta Bus Station
- Ave. Duration
- 16h
- Frequency
- Once daily
- Estimated price
- $65–180
- Website
- https://www.greyhound.com/
- Phone
- +1 (855) 626-8585
- Website
- flixbus.com
Bus from Miami Airport Station to Atlanta Bus Station
- Ave. Duration
- 13h 10m
- Frequency
- Once daily
- Estimated price
- $55–130
- Schedules at
- flixbus.com
Bus from Atlanta Bus Station to St Louis Bus Station
- Ave. Duration
- 10h 40m
- Frequency
- Once daily
- Estimated price
- $60–180
- Schedules at
- flixbus.com
Want to know more about travelling around United States
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Travelling to the US: What do I need to know?
Read the travel guide
Need to know: Greyhound
Read the travel guide
More Questions & Answers
Yes, the driving distance between Key West to St. Louis is 1360 miles. It takes approximately 23h 47m to drive from Key West to St. Louis.
There are 353+ hotels available in St. Louis.