There are 4 ways to get from Key West to St. Louis by plane, bus (Greyhound, Flixbus), or car
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly to Lambert–St. Louis International Airport
best- Fly from Key West International Airport (EYW) to Lambert–St. Louis International Airport (STL)EYW - STL
5h 24m$175–817Fly to Midamerica St. Louis Airport
cheapest- Fly from Key West International Airport (EYW) to Midamerica St. Louis Airport (BLV)EYW - BLV
9h 29m$138–526Bus
- Take the bus from N Roosevelt & 3rd Street to Big Pine Key - Auto Store / NAPA MM30Lks
- Take the bus from Big Pine Key to Miami Airport Station
- Take the bus from Miami Airport Station to Atlanta Bus Station
- Take the bus from Atlanta Bus Station to St Louis Bus Station
31h 31m$162–429Drive 1,352.3 mi
- Drive from Key West to St. Louis1,352.3 mi
23h 31m$247–357
Key West to St. Louis by bus and foot
Questions & Answers
The cheapest way to get from Key West to St. Louis is to bus which costs $160 - $430 and takes 31h 31m.
The fastest way to get from Key West to St. Louis is to fly which takes 5h 24m and costs $170 - $850.
No, there is no direct bus from Key West to St. Louis station. However, there are services departing from N Roosevelt & 3rd Street and arriving at St Louis Bus Station via Big Pine Key, Miami Airport Station and Atlanta Bus Station. The journey, including transfers, takes approximately 31h 31m.
The distance between Key West and St. Louis is 1125 miles. The road distance is 1360.2 miles.
The best way to get from Key West to St. Louis without a car is to bus which takes 31h 31m and costs $160 - $430.
It takes approximately 5h 24m to get from Key West to St. Louis, including transfers.
Key West to St. Louis bus services, operated by Key West Transit, depart from N Roosevelt & 3rd Street station.
The best way to get from Key West to St. Louis is to fly which takes 5h 24m and costs $170 - $850. Alternatively, you can bus, which costs $160 - $430 and takes 31h 31m.
Key West to St. Louis bus services, operated by Key West Transit, arrive at Big Pine Key - Auto Store / NAPA MM30 station.
St. Louis is 1h behind Key West. It is currently 9:52 AM in Key West and 8:52 AM in St. Louis.
What companies run services between Key West, FL, USA and St. Louis, MO, USA?
Delta, American Airlines, and two other airlines fly from Key West International Airport (EYW) to Lambert–St. Louis International Airport (STL) every 4 hours. Alternatively, you can take a bus from N Roosevelt & 3rd Street to St Louis Bus Station via Big Pine Key - Auto Store / NAPA MM30, Big Pine Key, Miami Airport Station, and Atlanta Bus Station in around 31h 31m.
- Website
- aa.com
Flights from Key West International Airport to Lambert–St. Louis International Airport via Charlotte
- Ave. Duration
- 6h 43m
- When
- Every day
- Estimated price
- $180–850
Flights from Key West International Airport to Lambert–St. Louis International Airport via Miami
- Ave. Duration
- 6h 51m
- When
- Every day
- Estimated price
- $170–800
- Website
- allegiantair.com
Flights from Key West International Airport to Midamerica St. Louis Airport via St. Petersburg
- Ave. Duration
- 13h 20m
- When
- Tuesday and Sunday
- Estimated price
- $100–480
Flights from Key West International Airport to Midamerica St. Louis Airport via Atlanta, Valparaiso
- Ave. Duration
- 8h 40m
- When
- Tuesday, Thursday, Saturday, and Sunday
- Estimated price
- $120–550
- Website
- delta.com
Flights from Key West International Airport to Lambert–St. Louis International Airport via Atlanta
- Ave. Duration
- 5h 58m
- When
- Every day
- Estimated price
- $160–800
- Website
- southwest.com
Flights from Key West International Airport to Lambert–St. Louis International Airport via Tampa
- Ave. Duration
- 4h 36m
- When
- Thursday
- Estimated price
- $160–800
- Phone
- +1 305-809-3700
- Website
- cityofkeywest-fl.gov
Bus from N Roosevelt & 3rd Street to Big Pine Key - Auto Store / NAPA MM30
- Ave. Duration
- 54 min
- Frequency
- Every 3 hours
- Estimated price
- $2–4
- Schedules at
- https://www.cityofkeywest-fl.gov/595/Schedules-and-Route-Maps
Rome2Rio's guide to Greyhound USA
Contact Details
- Phone
- +1 214-849-8100
- ifsr@greyhound.com
- Website
- greyhound.com
Bus from Big Pine Key to Miami Airport Station
- Ave. Duration
- 3h 35m
- Frequency
- 3 times a day
- Estimated price
- $30–65
- Website
- https://www.greyhound.com/
Bus from Miami Airport Station to Atlanta Bus Station
- Ave. Duration
- 13h 15m
- Frequency
- Once daily
- Estimated price
- $65–170
- Website
- https://www.greyhound.com/
- Phone
- +1 (855) 626-8585
- Website
- flixbus.com
Bus from Atlanta Bus Station to St Louis Bus Station
- Ave. Duration
- 10h 40m
- Frequency
- Once daily
- Estimated price
- $65–190
- Schedules at
- flixbus.com
Want to know more about travelling around United States
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Travelling to the US: What do I need to know?
Read the travel guide
Need to know: Greyhound
Read the travel guide
More Questions & Answers
Yes, the driving distance between Key West to St. Louis is 1360 miles. It takes approximately 23h 31m to drive from Key West to St. Louis.
There are 437+ hotels available in St. Louis.