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How to get fromKey West to St. Louisby plane, bus (Greyhound, Flixbus), or car

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There are 5 ways to get from Key West to St. Louis by plane, bus (Greyhound, Flixbus), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Lambert–St. Louis International Airport

    best
    1. Fly from Key West International Airport (EYW) to Lambert–St. Louis International Airport (STL)plane plane EYW - STL
    6h 2m
    $175–817

  2. Fly to Midamerica St. Louis Airport

    cheapest
    1. Fly from Key West International Airport (EYW) to Midamerica St. Louis Airport (BLV)plane plane EYW - BLV
    12h 45m
    $128–466

  3. Bus

    1. Take the bus from N Roosevelt & 3rd Street to Big Pine Key - Auto Store / NAPA MM30bus bus Lks
    2. Take the bus from Big Pine Key to Miami Airport Stationbus bus
    3. Take the bus from Miami Airport Station to Atlanta Bus Stationbus bus
    4. Take the bus from Atlanta Bus Station to St Louis Bus Stationbus bus
    31h 13m
    $176–404

  4. Drive 1,352.3 mi

    1. Drive from Key West to St. Louiscar car 1,352.3 mi
    23h 48m
    $247–357

  5. Bus via Evansville

    1. Take the bus from N Roosevelt & 3rd Street to Big Pine Key - Auto Store / NAPA MM30bus bus Lks
    2. Take the bus from Big Pine Key to Miami Airport Stationbus bus
    3. Take the bus from Miami Airport Station to Atlanta Bus Stationbus bus
    4. Take the bus from Atlanta Bus Station to Evansville Bus Stationbus bus
    5. Take the bus from Evansville Bus Station to St Louis Bus Stationbus bus
    33h 7m
    $186–414

Key West to St. Louis by bus and foot

Calendar14Weekly Services
Duration31h 13mAverage Duration
Ticket$176Cheapest Price
See schedules

Questions & Answers

Map of how to get from Key West to St. Louis.ExpandLaunch map view
  • Distance: 1,118.2 mi
  • Duration: 6h 2m

What companies run services between Key West, FL, USA and St. Louis, MO, USA?

American Airlines and Delta fly from Key West International Airport (EYW) to Lambert–St. Louis International Airport (STL) every 4 hours. Alternatively, you can take a bus from N Roosevelt & 3rd Street to St Louis Bus Station via Big Pine Key - Auto Store / NAPA MM30, Big Pine Key, Miami Airport Station, and Atlanta Bus Station in around 31h 13m.

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