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How to get fromKey West to Myrtle Beachby plane, bus, train, bus (Greyhound, Flixbus) or car

Find Transport to Myrtle Beach

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There are 4 ways to get from Key West to Myrtle Beach by plane, bus, train, bus (Greyhound, Flixbus), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly

    best
    1. Fly from Key West International Airport (EYW) to Myrtle Beach (MYR)planeEYW - MYR
    4h 51m
    $102–477
  2. Bus, train

    1. Take the bus from N Roosevelt & 4th Street to Big Pine Key - Auto Store / NAPA MM30busLks
    2. Take the bus from Big Pine Key to Miami Airport Stationbus
    3. Take the train from Hollywood Amtrak Station to Charleston Amtrak Stationtrain
    4. Take the bus from Charleston Bus Station to Myrtle Beach Bus Stationbus
    23h 55m
    $131–380
  3. Bus

    1. Take the bus from N Roosevelt & 3rd Street to Big Pine Key - Auto Store / NAPA MM30busLks
    2. Take the bus from Big Pine Key to Miami Airport Stationbus
    3. Take the bus from Miami Airport Station to Jacksonvillebus
    4. Take the bus from Jacksonville to Florence Bus Stationbus
    5. Take the bus from Florence to Myrtle Beach, SCbus
    24h 21m
    $136–339
  4. Drive 833.8 mi

    1. Drive from Key West to Myrtle Beachcar833.8 mi
    15h 11m
    $153–220

Key West to Myrtle Beach by bus, foot, and train

Calendar7Weekly Services
Duration23h 55mAverage Duration
Ticket$131Cheapest Price
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Questions & Answers

What companies run services between Key West, FL, USA and Myrtle Beach, SC, USA?

Delta, American Airlines, and Spirit Airlines fly from Key West International Airport (EYW) to Myrtle Beach (MYR) 5 times a day. Alternatively, you can take a bus from N Roosevelt & 3rd Street to Myrtle Beach, SC via Big Pine Key - Auto Store / NAPA MM30, Big Pine Key, Miami Airport Station, Jacksonville, Florence Bus Station, and Florence in around 24h 21m.

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