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How to get fromKey West to Myrtle Beachby plane, bus, train, bus (Greyhound, Flixbus), or car

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There are 5 ways to get from Key West to Myrtle Beach by plane, bus, train, bus (Greyhound, Flixbus), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Myrtle Beach

    best
    1. Fly from Key West International Airport (EYW) to Myrtle Beach (MYR)plane plane EYW - MYR
    4h 27m
    $98–398

  2. Bus, train

    1. Take the bus from N Roosevelt & 4th Street to Big Pine Key - Auto Store / NAPA MM30bus bus Lks
    2. Take the bus from Big Pine Key to Miami Airport Stationbus bus
    3. Take the train from Hollywood Amtrak Station to Charleston Amtrak Stationtrain train
    4. Take the bus from Charleston Bus Station to Myrtle Beach Bus Stationbus bus
    23h 45m
    $217–482

  3. Bus

    1. Take the bus from N Roosevelt & 3rd Street to Big Pine Key - Auto Store / NAPA MM30bus bus Lks
    2. Take the bus from Big Pine Key to Miami Airport Stationbus bus
    3. Take the bus from Miami Airport Station to Fayetteville Bus Stationbus bus
    4. Take the bus from Fayetteville Bus Station to Wilmington Cape Fear Public Transitbus bus
    5. Take the bus from Wilmington Cape Fear Public Transit to Myrtle Beach Bus Stationbus bus
    27h 52m
    $157–275

  4. Drive 833.9 mi

    1. Drive from Key West to Myrtle Beachcar car 833.9 mi
    15h 20m
    $153–220

  5. Fly to Wilmington International Airport, bus

    1. Fly from Key West International Airport (EYW) to Wilmington International Airport (ILM)plane plane EYW - ILM
    2. Take the bus from Wilmington Cape Fear Public Transit to Myrtle Beach Bus Stationbus bus
    6h 40m
    $117–473

Key West to Myrtle Beach by bus, foot, and train

Calendar7Weekly Services
Duration23h 45mAverage Duration
Ticket$217Cheapest Price
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Questions & Answers

Map of how to get from Key West to Myrtle Beach.ExpandLaunch map view
  • Distance: 658.4 mi
  • Duration: 4h 27m

What companies run services between Key West, FL, USA and Myrtle Beach, SC, USA?

American Airlines and Delta fly from Key West International Airport (EYW) to Myrtle Beach (MYR) 4 times a day. Alternatively, you can take a bus from N Roosevelt & 3rd Street to Myrtle Beach Bus Station via Big Pine Key - Auto Store / NAPA MM30, Big Pine Key, Miami Airport Station, Fayetteville Bus Station, and Wilmington Cape Fear Public Transit in around 27h 52m.

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