• Our partners include:

  • Greyhound USA
  • VIA Rail
  • Amtrak
  • Acela Express
  • Megabus
  • SuperShuttle
  • Booking.com
  • Skyscanner
  • Airbnb
  • Expedia

There are 5 ways to get from Key West to Knoxville by plane, ferry, bus or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly  •  5h 19m

  1. Fly from Key West (EYW) to Knoxville (TYS) EYW - TYS

$247 - $1,024

Cheapest option

Bus  •  2 days 2h

  1. Take the bus from Key West, Fl to Miami, Fl
  2. Take the bus from Miami, Fl to New York, Ny
  3. Take the bus from New York, NY to Knoxville Nyc

$204 - $344

3 alternative options

Ferry, bus via Tampa  •  42h 46m

  1. Take the ferry from Key West, FL to Marco Island, FL
  2. Take the bus from Naples to Tampa Downtown
  3. Take the bus from Tampa to New York
  4. Take the bus from New York, NY to Knoxville Nyc

$307 - $442

Ferry, bus  •  44h 58m

  1. Take the ferry from Key West, FL to Marco Island, FL
  2. Take the bus from Naples, FL to New York, NY
  3. Take the bus from New York, NY to Knoxville Nyc

$310 - $435

Drive  •  17h 43m

  1. Drive from Key West to Knoxville 1028.7 miles

$100 - $150

Questions & Answers

The cheapest way to get from Key West to Knoxville is to drive which costs $100 - $150 and takes 17h 43m.

More details

The quickest way to get from Key West to Knoxville is to fly which costs $240 - $1,100 and takes 5h 19m.

More details

The distance between Key West and Knoxville is 803 miles. The road distance is 1028.7 miles.

Get driving directions

The best way to get from Key West to Knoxville without a car is to ferry and bus via Tampa which takes 42h 46m and costs $300 - $450.

More details

It takes approximately 5h 19m to get from Key West to Knoxville, including transfers.

More details

The best way to get from Key West to Knoxville is to fly which takes 5h 19m and costs $240 - $1,100. Alternatively, you can bus, which costs $200 - $350 and takes 2 days 2h.

Mode details

There is no direct flight from Key West Airport to Knoxville Airport. The quickest flight takes 3h 55m and has one stopover.

Search flights

Yes, the driving distance between Key West to Knoxville is 1029 miles. It takes approximately 17h 43m to drive from Key West to Knoxville.

Get driving directions

United Airlines, Delta and American Airlines offer flights from Key West Airport to Knoxville Airport.

Search flights

There are 126+ hotels available in Knoxville. Prices start at $59 USD per night.

More details

Map of how to get from Key West to Knoxville.
Launch map view
  • Distance: 802.9 miles
  • Duration: 5h 19m

What companies run services between Key West, FL, USA and Knoxville, TN, USA?

Delta, American Airlines and three other airlines fly from Key West to Knoxville hourly. Alternatively, you can take a bus from Key West to Knoxville via Key West, Fl, Miami, Fl, New York, Ny, 42 St - Port Authority Bus Terminal, Spring St, New York, NY, Knoxville, and Kingston Pike EB Mid-block just past Walker Springs in around 2 days 2h.

Airlines
American Airlines
Website
aa.com
Flights from Key West to Knoxville via Miami
Ave. Duration
4h 21m
When
Every day
Estimated price
$210 - $950
Flights from Key West to Knoxville via Charlotte
Ave. Duration
4h 31m
When
Every day
Estimated price
$210 - $1,000
Flights from Key West to Knoxville via Chicago O'Hare
Ave. Duration
6h 6m
When
Saturday
Estimated price
$280 - $1,100
Flights from Key West to Knoxville via Dallas/Ft.Worth
Ave. Duration
7h 26m
When
Every day
Estimated price
$290 - $1,200
Flights from Key West to Knoxville via Reagan Washington
Ave. Duration
8h 8m
When
Saturday
Estimated price
$260 - $1,100
Flights from Key West to Knoxville via Miami, Charlotte
Ave. Duration
7h 12m
When
Every day
Estimated price
$220 - $1,000
Delta
Website
delta.com
Flights from Key West to Knoxville via Atlanta
Ave. Duration
4h 10m
When
Every day
Estimated price
$190 - $950
United Airlines
Website
united.com
Flights from Key West to Knoxville via Newark
Ave. Duration
8h 37m
When
Every day
Estimated price
$290 - $1,200
Bus operators
Red Coach
Starline Express
Phone
917-656-4221
Email
nycstarline@gmail.com
Website
starlinebus.com
Bus from Tampa to New York
Ave. Duration
21h 15m
Frequency
Once daily
Estimated price
$80 - $100
Schedules at
gotobus.com
Book at
gotobus.com
Atlanta Tours Inc
Bus from Tampa to New York
Ave. Duration
22h 45m
Frequency
Once daily
Estimated price
$85 - $110
Schedules at
gotobus.com
Book at
gotobus.com
Wanda Coach
Phone
646-630-7186
Email
help@wandacoach.com
Website
wandacoach.com
Bus from New York, NY to Knoxville
Ave. Duration
11h 30m
Frequency
6 times a week
Estimated price
$45 - $70
Book at
GoTo Bus
NYTN Bus
Phone
+1 615-939-8887
Email
tennesseetravel@gotobus.com
Website
nytnbus.com
Bus from New York, NY to Knoxville
Ave. Duration
12h
Frequency
Twice a week
Estimated price
$70 - $120
Schedules at
nytnbus.com
Book at
gotobus.com
La Cubana
Phone
+1 305-541-1700
Website
lacubanabus.com
Bus from Naples, FL to New York, NY
Ave. Duration
26h
Frequency
3 times a week
Estimated price
$120 - $160
Schedules at
lacubanabus.com
Greyhound USA

Greyhound is a leading bus company based in Dallas, Texas, serving over 3800 destinations across North America, Mexico and Canada. Greyhound carries around 18 million passengers a year who travel 5.4 billion miles (8.6 billion km) a year on their fleet of around 1700 vehicles. For travel flexibility, you can board or get off a Greyhound bus at official Greyhound stations, partner stations and curbside stops. There are around 230 Greyhound stations across the US where you can both catch your bus and buy tickets, that are also available on the official website and via the mobile app.

Rome2rio's guide to Greyhound USA
Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from Key West, Fl to Miami, Fl
Ave. Duration
4h 15m
Frequency
Twice daily
Estimated price
$22 - $35
Website
greyhound.com
Economy
$22 - $35
Flexible
$40 - $65
Bus from Miami, Fl to New York, Ny
Ave. Duration
29h 40m
Frequency
3 times a day
Estimated price
$130 - $180
Website
greyhound.com
Economy
$130 - $180
Flexible
$190 - $270
Ferry operators
Key West Express
Phone
+1 239-463-5733
Website
keywestexpress.net
Ferry from Key West, FL to Marco Island, FL
Ave. Duration
3h
Frequency
Once daily
Estimated price
$95
Book at
Key West Express

Want to know more about travelling around United States

Rome2rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

More Questions & Answers

The best way to get from Key West to Key West Airport is to bus which takes 6m and costs $2 - $4.

More details