There are 9 ways to get from Key West to Gainesville by plane, shuttle, bus, car, bus (Greyhound, Flixbus), train, or ferry
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly to Gainesville Regional Airport
best- Fly from Key West International Airport (EYW) to Gainesville Regional Airport (GNV)EYW - GNV
5h 40m$74–386Bus, train
cheapest- Take the bus from N Roosevelt & 3rd Street to Big Pine Key - Auto Store / NAPA MM30Lks
- Take the bus from Big Pine Key to Miami Airport Station
- Take the train from Miami Airport Station to West Palm Beach Station
- Take the bus from West Palm Beach, FL to Gainesville - Commuter Lot Parking Garage @ Gale Lemerand
13h 50m$65–165Shuttle, bus
- Take a shuttle bus from Key West, FL to Miami, FL - International AirportTo the Airports
- Take the bus from Miami Airport to Gainesville - Commuter Lot Parking Garage @ Gale LemerandMiami-Tallahassee / ...
12h 42m$182–314Drive 474.7 mi
- Drive from Key West to Gainesville474.7 mi
9h 16m$87–126Fly to Orlando, bus
- Fly from Key West International Airport (EYW) to Orlando (MCO)EYW - MCO
- Take the bus from Orlando RedCoach Station to Gainesville
4h 35m$128–426Fly to Jacksonville, bus
- Fly from Key West International Airport (EYW) to Jacksonville (JAX)EYW - JAX
- Take the bus from Jacksonville to Gainesville
7h 41m$470–991Bus
- Take the bus from N Roosevelt & 3rd Street to Big Pine Key - Auto Store / NAPA MM30Lks
- Take the bus from Big Pine Key to Miami Airport Station
- Take the bus from Miami Airport Station to Gainesville
13h 26m$77–179Bus, train via Meadow Woods
- Take the bus from N Roosevelt & 4th Street to Big Pine Key - Auto Store / NAPA MM30Lks
- Take the bus from Big Pine Key to Miami Airport Station
- Take the train from Miami to Orlando
- Take the bus from Orlando RedCoach Station to Gainesville
13h 41m$81–383Ferry, bus
- Take the ferry from Key West, FL to Fort Myers Beach, FL
- Take the bus from Fort Myers Bus Stop to Orlando Bus Station
- Take the bus from Orlando Bus Station to Gainesville
16h 25m$195–244
Key West to Gainesville by bus and shuttle
Questions & Answers
The cheapest way to get from Key West to Gainesville is to bus and train which costs $65 - $170 and takes 13h 50m.
The fastest way to get from Key West to Gainesville is to fly and bus which takes 4h 35m and costs $120 - $430.
No, there is no direct bus from Key West to Gainesville. However, there are services departing from N Roosevelt & 3rd Street and arriving at Gainesville via Big Pine Key and Miami Airport Station. The journey, including transfers, takes approximately 13h 26m.
The distance between Key West and Gainesville is 368 miles. The road distance is 477.4 miles.
The best way to get from Key West to Gainesville without a car is to shuttle and bus which takes 12h 42m and costs $180 - $320.
It takes approximately 5h 40m to get from Key West to Gainesville, including transfers.
Key West to Gainesville bus services, operated by Key West Transit, depart from N Roosevelt & 3rd Street station.
The best way to get from Key West to Gainesville is to fly which takes 5h 40m and costs $70 - $390. Alternatively, you can bus, which costs $75 - $180 and takes 13h 26m.
Key West to Gainesville bus services, operated by Key West Transit, arrive at Big Pine Key - Auto Store / NAPA MM30 station.
Yes, the driving distance between Key West to Gainesville is 477 miles. It takes approximately 9h 16m to drive from Key West to Gainesville.
What companies run services between Key West, FL, USA and Gainesville, FL, USA?
American Airlines and Delta fly from Key West International Airport (EYW) to Gainesville Regional Airport (GNV) every 4 hours. Alternatively, you can take a bus from N Roosevelt & 3rd Street to Gainesville via Big Pine Key - Auto Store / NAPA MM30, Big Pine Key, and Miami Airport Station in around 13h 26m.
- Website
- aa.com
Flights from Key West International Airport to Gainesville Regional Airport via Miami
- Ave. Duration
- 4h 14m
- When
- Every day
- Estimated price
- $60–370
Flights from Key West International Airport to Gainesville Regional Airport via Charlotte
- Ave. Duration
- 5h 40m
- When
- Every day
- Estimated price
- $100–550
Flights from Key West International Airport to Gainesville Regional Airport via Dallas/Ft.Worth
- Ave. Duration
- 7h 52m
- When
- Monday, Tuesday, Thursday, Friday, Saturday, and Sunday
- Estimated price
- $150–700
Flights from Key West International Airport to Orlando via Miami
- Ave. Duration
- 3h 18m
- When
- Every day
- Estimated price
- $45–310
Flights from Key West International Airport to Jacksonville via Miami
- Ave. Duration
- 3h 45m
- When
- Every day
- Estimated price
- $85–500
Flights from Key West International Airport to Jacksonville via Charlotte
- Ave. Duration
- 5h 20m
- When
- Every day
- Estimated price
- $130–700
- Website
- delta.com
Flights from Key West International Airport to Gainesville Regional Airport via Atlanta
- Ave. Duration
- 4h 49m
- When
- Every day
- Estimated price
- $90–480
Flights from Key West International Airport to Jacksonville via Atlanta
- Ave. Duration
- 4h 39m
- When
- Every day
- Estimated price
- $120–650
- Website
- flybreeze.com
Flights from Key West International Airport to Orlando
- Ave. Duration
- 1h 10m
- When
- Monday, Thursday, Friday, and Sunday
- Estimated price
- $110–550
- Phone
- +1 831-539-2901
- guestservices@gobrightline.com
- Website
- gobrightline.com
Train from Miami to Orlando
- Ave. Duration
- 3h 34m
- Frequency
- Every 3 hours
- Estimated price
- $15–230
- Book at
- https://www.gobrightline.com
- Smart
- $15–200
- Premium
- $65–230
- Phone
- +1 800-874-7245
- Website
- tri-rail.com
Train from Miami Airport Station to West Palm Beach Station
- Ave. Duration
- 1h 45m
- Frequency
- Hourly
- Estimated price
- $5–11
- Website
- https://www.tri-rail.com
- Weekend | Holiday
- $5
- Weekday
- $8–11
- Phone
- +1 (305) 289-9997
- groups@keysshuttle.com
- Website
- keysshuttle.com
Shuttle from Key West, FL to Miami, FL - International Airport
- Ave. Duration
- 4h
- Frequency
- 4 times a day
- Estimated price
- $150–210
- Website
- https://www.keysshuttle.com
- Phone
- +1 877 733 0724
- Website
- redcoachusa.com
Bus from Miami Airport to Gainesville - Commuter Lot Parking Garage @ Gale Lemerand
- Ave. Duration
- 6h 35m
- Frequency
- 5 times a day
- Estimated price
- $30–100
- Website
- https://www.redcoachusa.com
- Web
- $30–100
Bus from Orlando RedCoach Station to Gainesville
- Ave. Duration
- 1h 55m
- Frequency
- Every 4 hours
- Estimated price
- $14–60
- Website
- https://www.redcoachusa.com
- Web
- $14–60
Bus from West Palm Beach, FL to Gainesville - Commuter Lot Parking Garage @ Gale Lemerand
- Ave. Duration
- 4h 56m
- Frequency
- 4 times a day
- Estimated price
- $28–85
- Website
- https://www.redcoachusa.com
- Web
- $28–85
- Phone
- +1 (855) 626-8585
- Website
- flixbus.com
Bus from Jacksonville to Gainesville
- Ave. Duration
- 1h 30m
- Frequency
- 6 times a week
- Estimated price
- $17–24
- Schedules at
- flixbus.com
Bus from Miami Airport Station to Gainesville
- Ave. Duration
- 6h 50m
- Frequency
- Twice daily
- Estimated price
- $45–110
- Schedules at
- flixbus.com
Bus from Fort Myers Bus Stop to Orlando Bus Station
- Ave. Duration
- 5h 10m
- Frequency
- 4 times a day
- Estimated price
- $35–55
- Schedules at
- flixbus.com
Bus from Orlando Bus Station to Gainesville
- Ave. Duration
- 2h 5m
- Frequency
- Every 4 hours
- Estimated price
- $27–50
- Schedules at
- flixbus.com
- Phone
- +1 305-809-3700
- Website
- cityofkeywest-fl.gov
Bus from N Roosevelt & 3rd Street to Big Pine Key - Auto Store / NAPA MM30
- Ave. Duration
- 54 min
- Frequency
- Every 3 hours
- Estimated price
- $2–4
- Schedules at
- https://www.cityofkeywest-fl.gov/595/Schedules-and-Route-Maps
Bus from N Roosevelt & 4th Street to Big Pine Key - Auto Store / NAPA MM30
- Ave. Duration
- 53 min
- Frequency
- Every 3 hours
- Estimated price
- $2–4
- Schedules at
- https://www.cityofkeywest-fl.gov/595/Schedules-and-Route-Maps
Rome2Rio's guide to Greyhound USA
Contact Details
- Phone
- +1 214-849-8100
- ifsr@greyhound.com
- Website
- greyhound.com
Bus from Big Pine Key to Miami Airport Station
- Ave. Duration
- 3h 35m
- Frequency
- 3 times a day
- Estimated price
- $30–65
- Website
- https://www.greyhound.com/
- Phone
- +1 239-463-5733
- Website
- keywestexpress.net
Ferry from Key West, FL to Fort Myers Beach, FL
- Ave. Duration
- 4h
- Frequency
- Once daily
- Estimated price
- $130
- Website
- https://www.keywestexpress.net
Want to know more about travelling around United States
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Travelling to the US: What do I need to know?
Read the travel guide
Need to know: Greyhound
Read the travel guide
More Questions & Answers
There are 213+ hotels available in Gainesville.



















