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How to get fromKey West to Gainesvilleby plane, bus (Greyhound, Flixbus), car, bus, train, or ferry

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There are 9 ways to get from Key West to Gainesville by plane, bus (Greyhound, Flixbus), car, bus, train, or ferry

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Gainesville Regional Airport

    best
    1. Fly from Key West International Airport (EYW) to Gainesville Regional Airport (GNV)plane plane EYW - GNV
    5h 32m
    $64–326

  2. Bus

    1. Take the bus from N Roosevelt & 3rd Street to Big Pine Key - Auto Store / NAPA MM30bus bus Lks
    2. Take the bus from Big Pine Key to Miami Airport Stationbus bus
    3. Take the bus from Miami Airport Station to Gainesvillebus bus
    13h 22m
    $76–139

  3. Drive 474.6 mi

    1. Drive from Key West to Gainesvillecar car 474.6 mi
    9h 22m
    $87–126

  4. Fly to Orlando, bus

    1. Fly from Key West International Airport (EYW) to Orlando (MCO)plane plane EYW - MCO
    2. Take the bus from Orlando - RedCoach Station, FL to University of Florida - 1956 Gale Lemerand Drbus bus
    5h 3m
    $113–721

  5. Fly to Orlando Sanford, drive

    1. Fly from Key West International Airport (EYW) to Orlando Sanford (SFB)plane plane EYW - SFB
    2. Drive from Orlando-Sanford-Airport-SFB to Gainesvillecar car
    3h 44m
    $77–334

  6. Fly to Jacksonville, bus

    1. Fly from Key West International Airport (EYW) to Jacksonville (JAX)plane plane EYW - JAX
    2. Take the bus from Jacksonville to Gainesvillebus bus
    8h 21m
    $384–836

  7. Bus, train

    1. Take the bus from N Roosevelt & 3rd Street to Big Pine Key - Auto Store / NAPA MM30bus bus Lks
    2. Take the bus from Big Pine Key to Miami Airport Stationbus bus
    3. Take the train from Miami Airport Station to West Palm Beach Stationtrain train
    4. Take the bus from West Palm Beach, FL to University of Florida - 1956 Gale Lemerand Drbus bus
    13h 54m
    $91–185

  8. Ferry, bus

    1. Take the ferry from Key West, FL to Fort Myers Beach, FLferry ferry
    2. Take the bus from Fort Myers Bus Stop to University of South Floridabus bus
    3. Take the bus from University of South Florida to Gainesvillebus bus
    15h 28m
    $175–214

  9. Bus, train via Tampa

    1. Take the bus from N Roosevelt & 4th Street to Big Pine Key - Auto Store / NAPA MM30bus bus Lks
    2. Take the bus from Big Pine Key to Miami Airport Stationbus bus
    3. Take the train from Miami Airport Station to Delray Beach Stationtrain train
    4. Take the train from Delray Beach Amtrak to Tampatrain train
    5. Take the bus from Tampa Bus Station to Gainesvillebus bus
    16h 33m
    $116–237

Key West to Gainesville by bus and foot

Calendar9Weekly Services
Duration13h 22mAverage Duration
Ticket$76Cheapest Price
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Questions & Answers

Map of how to get from Key West to Gainesville.ExpandLaunch map view
  • Distance: 365.5 mi
  • Duration: 5h 32m

What companies run services between Key West, FL, USA and Gainesville, FL, USA?

American Airlines and Delta fly from Key West International Airport (EYW) to Gainesville Regional Airport (GNV) 5 times a day. Alternatively, you can take a bus from N Roosevelt & 3rd Street to Gainesville via Big Pine Key - Auto Store / NAPA MM30, Big Pine Key, and Miami Airport Station in around 13h 22m.

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