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There are 4 ways to get from Key West to Charleston by plane, bus, train or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly  •  5h 22m

  1. Fly from Key West (EYW) to Charleston (CHS) EYW - CHS

$184 - $929

Cheapest option

Bus  •  24h 22m

  1. Take the bus from Key West, Fl to Miami, Fl
  2. Take the bus from Miami, Fl to Savannah, Ga
  3. Take the bus from Savannah, GA to Charleston, SC

$102 - $157

2 alternative options

Bus, train, drive  •  19h 55m

  1. Take the bus from Key West, FL - Mel Fisher Museum to Miami, FL - Airport Regency Hotel 401
  2. Take the train from Fort Lauderdale Amtrak Station to Yemassee Amtrak
  3. Drive from Yemassee Amtrak to Charleston

$115 - $188

Drive  •  13h 14m

  1. Drive from Key West to Charleston 745.9 miles

$70 - $110

Questions & Answers

The cheapest way to get from Key West to Charleston is to drive which costs $70 - $110 and takes 13h 14m.

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The quickest way to get from Key West to Charleston is to fly which costs $180 - $950 and takes 5h 22m.

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No, there is no direct bus from Key West to Charleston. However, there are services departing from Flagler & Josephine and arriving at Transit Mall via Key West, Fl, Miami, Fl, Savannah, GA and Dorchester Rd / South Allen Dr. The journey, including transfers, takes approximately 24h 22m.

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The distance between Key West and Charleston is 582 miles. The road distance is 745.9 miles.

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The best way to get from Key West to Charleston without a car is to bus which takes 24h 22m and costs $100 - $160.

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It takes approximately 5h 22m to get from Key West to Charleston, including transfers.

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Key West to Charleston bus services, operated by Greyhound USA, depart from Key West, Fl station.

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The best way to get from Key West to Charleston is to fly which takes 5h 22m and costs $180 - $950. Alternatively, you can bus, which costs $100 - $160 and takes 24h 22m.

Mode details

There is no direct flight from Key West Airport to Charleston Airport. The quickest flight takes 3h 34m and has one stopover.

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Key West to Charleston bus services, operated by South Eastern Stages, arrive at Charleston, SC station.

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Map of how to get from Key West to Charleston.
Launch map view
  • Distance: 582.4 miles
  • Duration: 5h 22m

What companies run services between Key West, FL, USA and Charleston, SC, USA?

American Airlines, Delta and two other airlines fly from Key West to Charleston hourly. Alternatively, you can take a bus from Key West to Charleston via Key West, Fl, Miami, Fl, Savannah, Ga, Savannah, GA, Charleston, SC, and Dorchester Rd / South Allen Dr in around 24h 22m.

Airlines
American Airlines
Website
aa.com
Flights from Key West to Charleston via Miami
Ave. Duration
4h 42m
When
Every day
Estimated price
$200 - $950
Flights from Key West to Charleston via Charlotte
Ave. Duration
5h 26m
When
Saturday
Estimated price
$220 - $1,000
Flights from Key West to Charleston via Reagan Washington
Ave. Duration
5h 39m
When
Sunday
Estimated price
$270 - $1,100
Flights from Key West to Charleston via Dallas/Ft.Worth
Ave. Duration
6h 54m
When
Every day
Estimated price
$320 - $1,200
Flights from Key West to Charleston via Philadelphia
Ave. Duration
6h 39m
When
Saturday
Estimated price
$290 - $1,200
Flights from Key West to Charleston via Miami, Charlotte
Ave. Duration
7h 38m
When
Monday to Friday
Estimated price
$230 - $1,000
Delta
Website
delta.com
Flights from Key West to Charleston via Atlanta
Ave. Duration
5h 12m
When
Every day
Estimated price
$210 - $1,000
JetBlue Airways
Website
jetblue.com
Flights from Key West to Charleston via Fort Lauderdale
Ave. Duration
4h 36m
When
Every day
Estimated price
$180 - $900
Train operators
Amtrak

Amtrak is a rail service that connects the US and three Canadian provinces. Covering 21,000 route miles (34,000km) Amtrak operates more than 300 trains daily. These medium and long distance intercity services operate at speeds of up to 240km/h, to more than 500 destinations. Founded in 1971, it is based in Washington, D.C. and offers four classes of travel: First Class, Sleeper, Business and Coach. Ticket fares are divided into five subclasses: Saver, Value, Flexible, Business and Premium. Amtrak trains are known for their wide seats, plug-in power, big windows and storage capabilities.

Rome2rio's guide to Amtrak
Contact Details
Phone
+1 215-856-7924
Website
amtrak.com
Train from Fort Lauderdale Amtrak Station to Yemassee Amtrak
Ave. Duration
11h 30m
Frequency
Once daily
Estimated price
$65 - $95
Website
amtrak.com
Coach Seat
$65 - $95
Premium
$260 - $370
Flexi Coach Seat
$130 - $190
Business Seat
$130 - $200
Bus operators
The Florida Express Bus
Phone
407-442-2810
Website
busticketreservations.com
Bus from Key West, FL - Mel Fisher Museum to Miami, FL - Airport Regency Hotel
Ave. Duration
3h 30m
Frequency
Once daily
Estimated price
$27 - $60
More information at
American Bus Tickets
Greyhound USA

Greyhound is a leading bus company based in Dallas, Texas, serving over 3800 destinations across North America, Mexico and Canada. Greyhound carries around 18 million passengers a year who travel 5.4 billion miles (8.6 billion km) a year on their fleet of around 1700 vehicles. For travel flexibility, you can board or get off a Greyhound bus at official Greyhound stations, partner stations and curbside stops. There are around 230 Greyhound stations across the US where you can both catch your bus and buy tickets, that are also available on the official website and via the mobile app.

Rome2rio's guide to Greyhound USA
Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from Key West, Fl to Miami, Fl
Ave. Duration
4h 15m
Frequency
Twice daily
Estimated price
$22 - $35
Website
greyhound.com
Economy
$22 - $35
Flexible
$40 - $65
Bus from Miami, Fl to Savannah, Ga
Ave. Duration
13h 55m
Frequency
Every 4 hours
Estimated price
$55 - $80
Website
greyhound.com
Economy
$55 - $80
Flexible
$90 - $130

Want to know more about travelling around United States

Rome2rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

More Questions & Answers

Yes, the driving distance between Key West to Charleston is 746 miles. It takes approximately 13h 14m to drive from Key West to Charleston.

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Silver Airways, JetBlue Airways, Delta and American Airlines offer flights from Key West Airport to Charleston Airport.

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There are 905+ hotels available in Charleston. Prices start at $176 USD per night.

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The best way to get from Key West to Key West Airport is to bus which takes 6m and costs $2 - $4.

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