There are 6 ways to get from Key Largo to Sanibel by bus, taxi, car, shuttle, plane, or bus (Greyhound, Flixbus)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Bus, taxi
best- Take the bus from Key Largo Bus Stop to Miami Airport Stationbus
- Take the bus from Miami Airport to Fort Myers 7-11bus
- Take the taxi from Fort Myers 7-11 to Sanibeltaxi
6h 13m$88–226Drive 182.5 mi
cheapest- Drive from Key Largo to Sanibelcar 182.5 mi
3h 56m$34–49Shuttle, fly to Ft. Myers
- Take a shuttle bus from Key Largo, FL to Miami, FL - International Airport
- Fly from Miami International Airport (MIA) to Ft. Myers (RSW)plane MIA - RSW
6h 36m$186–517Bus, taxi via Golden Gate
- Take the bus from Key Largo Bus Stop to Miami Airport Stationbus
- Take the bus from Fort Lauderdale Airport to Naples, FLbus
- Take the taxi from Naples, FL to Sanibeltaxi
6h 41m$135–287Bus
- Take the bus from Key Largo Bus Stop to Miami Airport Stationbus Greyhound US0720s
- Take the bus from Miami Airport Station to Fort Myers Bus Stopbus FlixBus 2421
7h 56m$71–109Shuttle, fly to Tampa, bus, taxi
- Take a shuttle bus from Key Largo, FL to Miami, FL - International Airport
- Fly from Miami International Airport (MIA) to Tampa (TPA)plane MIA - TPA
- Take the bus from Tampa International Airport to Fort Myers 7-11bus
- Take the taxi from Fort Myers 7-11 to Sanibeltaxi
7h 13m$254–687
Miami International Airport (MIA) to Ft. Myers (RSW) flights
Questions & Answers
The cheapest way to get from Key Largo to Sanibel is to drive which costs $30 - $50 and takes 3h 56m.
The fastest way to get from Key Largo to Sanibel is to drive which takes 3h 56m and costs $30 - $50.
The distance between Key Largo and Sanibel is 252 miles. The road distance is 183.5 miles.
The best way to get from Key Largo to Sanibel without a car is to bus and taxi which takes 6h 13m and costs $85 - $230.
It takes approximately 6h 13m to get from Key Largo to Sanibel, including transfers.
Yes, the driving distance between Key Largo to Sanibel is 184 miles. It takes approximately 3h 56m to drive from Key Largo to Sanibel.
There are 684+ hotels available in Sanibel.
What companies run services between Key Largo, FL, USA and Sanibel, FL, USA?
You can take a bus from Key Largo Bus Stop to Sanibel via Miami Airport Station, Rosa Parks Transportation Ctr, and Cape Coral Transfer Center in around 7h 56m.
- Website
- aa.com
Flights from Miami International Airport to Ft. Myers via Charlotte
- Ave. Duration
- 5h 55m
- When
- Every day
- Estimated price
- $100–550
Flights from Miami International Airport to Tampa
- Ave. Duration
- 1h 10m
- When
- Every day
- Estimated price
- $35–250
- Website
- delta.com
Flights from Miami International Airport to Ft. Myers via Atlanta
- Ave. Duration
- 5h 17m
- When
- Every day
- Estimated price
- $95–490
- Website
- southwest.com
Flights from Miami International Airport to Ft. Myers via Orlando
- Ave. Duration
- 4h 17m
- When
- Monday to Saturday
- Estimated price
- $50–340
- Website
- flyfrontier.com
Flights from Miami International Airport to Ft. Myers via Atlanta
- Ave. Duration
- 6h 30m
- When
- Sunday
- Estimated price
- $95–490
Rome2Rio's guide to Greyhound USA
Contact Details
- Phone
- +1 214-849-8100
- ifsr@greyhound.com
- Website
- greyhound.com
Bus from Key Largo Bus Stop to Miami Airport Station
- Ave. Duration
- 1h 35m
- Frequency
- 3 times a day
- Estimated price
- $14–22
- Website
- https://www.greyhound.com/
- Phone
- +1 877 733 0724
- Website
- redcoachusa.com
Bus from Miami Airport to Fort Myers 7-11
- Ave. Duration
- 2h 55m
- Frequency
- 3 times a day
- Estimated price
- $23–140
- Website
- https://www.redcoachusa.com
- Web
- $23–140
Bus from Fort Lauderdale Airport to Naples, FL
- Ave. Duration
- 1h 35m
- Frequency
- 3 times a day
- Estimated price
- $22–140
- Website
- https://www.redcoachusa.com
- Web
- $22–140
Bus from Tampa International Airport to Fort Myers 7-11
- Ave. Duration
- 2h 10m
- Frequency
- 5 times a week
- Estimated price
- $23–140
- Website
- https://www.redcoachusa.com
- Web
- $23–140
- Phone
- +1 (305) 289-9997
- groups@keysshuttle.com
- Website
- keysshuttle.com
Shuttle from Key Largo, FL to Miami, FL - International Airport
- Ave. Duration
- 1h 15m
- Frequency
- 4 times a day
- Estimated price
- $85–120
- Website
- https://www.keysshuttle.com
- Phone
- +1 (855) 626-8585
- Website
- flixbus.com
Bus from Miami Airport Station to Fort Myers Bus Stop
- Ave. Duration
- 3h 25m
- Frequency
- 4 times a day
- Estimated price
- $25–45
- Schedules at
- flixbus.com
- Ave. Duration
- 44 min
- Estimated price
- $50–120
Gulf Coast Car Service
- Phone
- +1 941-391-8800
- Website
- gulfcoastcarservice.com
CT TAXI Transportation LLC
- Phone
- +1 239-218-9590
EJ Taxi
Naples Luxury taxi Transportation
- Phone
- +1 239-352-3333
Naples FL Taxi
- Phone
- +1 239-777-0777
- Website
- naplesfltaxi.com
Gulf Coast Car Service
- Phone
- +1 941-391-8800
- Website
- gulfcoastcarservice.com
CT TAXI Transportation LLC
- Phone
- +1 239-218-9590
EJ Taxi
Want to know more about travelling around United States
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Travelling to the US: What do I need to know?
Read the travel guide
Need to know: Greyhound
Read the travel guide








