There are 12 ways to get from Key Largo to Gainesville by bus, plane, bus (Greyhound, Flixbus), train, car, shuttle, or bus (Greyhound)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Bus to Miami International Airport, fly to Gainesville Regional Airport
best- Take the bus from Key Largo Bus Stop to Miami Airport Stationbus
- Fly from Miami International Airport (MIA) to Gainesville Regional Airport (GNV)plane MIA - GNV
5h$51–299Bus
- Take the bus from Key Largo Bus Stop to Miami Airport Stationbus Greyhound US0720s
- Take the bus from Miami Airport Station to Gainesvillebus FlixBus 2410 / ...
9h 5m$59–107Bus, train via Meadow Woods
- Take the bus from Key Largo Bus Stop to Miami Airport Stationbus
- Take the train from Miami to Orlandotrain
- Take the bus from Orlando - RedCoach Station, FL to University of Florida - 1956 Gale Lemerand Drbus
9h 47m$101–274Drive 377.4 mi
- Drive from Key Largo to Gainesvillecar 377.4 mi
7h 6m$69–100Bus to Miami International Airport, fly to Orlando, bus
- Take the bus from Key Largo Bus Stop to Miami Airport Stationbus
- Fly from Miami International Airport (MIA) to Orlando (MCO)plane MIA - MCO
- Take the bus from Orlando - RedCoach Station, FL to University of Florida - 1956 Gale Lemerand Drbus
7h 8m$590–1,179Bus to Miami International Airport, fly to Jacksonville, bus
- Take the bus from Key Largo Bus Stop to Miami Airport Stationbus
- Fly from Miami International Airport (MIA) to Jacksonville (JAX)plane MIA - JAX
- Take the bus from Jacksonville to Gainesvillebus
7h 47m$70–368Shuttle to Fort Lauderdale–Hollywood International Airport, fly to Orlando, bus
- Take a shuttle bus from Key Largo, FL to Fort Lauderdale, FL - International Airport
- Fly from Fort Lauderdale–Hollywood International Airport (FLL) to Orlando (MCO)plane FLL - MCO
- Take the bus from Orlando - RedCoach Station, FL to University of Florida - 1956 Gale Lemerand Drbus
7h 32m$408–807Shuttle to Fort Lauderdale–Hollywood International Airport, fly to Jacksonville, bus
- Take a shuttle bus from Key Largo, FL to Fort Lauderdale, FL - International Airport
- Fly from Fort Lauderdale–Hollywood International Airport (FLL) to Jacksonville (JAX)plane FLL - JAX
- Take the bus from Jacksonville to Gainesvillebus
8h 5m$258–766Bus to Miami International Airport, fly to Tampa, bus
- Take the bus from Key Largo Bus Stop to Miami Airport Stationbus
- Fly from Miami International Airport (MIA) to Tampa (TPA)plane MIA - TPA
- Take the bus from Tampa Bus Station to Gainesvillebus
8h 12m$781–1,154Bus to Miami International Airport, fly to Tallahassee, bus
- Take the bus from Key Largo Bus Stop to Miami Airport Stationbus
- Fly from Miami International Airport (MIA) to Tallahassee (TLH)plane MIA - TLH
- Take the bus from Tallahassee to Gainesvillebus
7h 40m$120–475Bus, train
- Take the bus from Key Largo Bus Stop to Miami Airport Stationbus
- Take the train from Miami Airport Station to West Palm Beach Stationtrain
- Take the bus from West Palm Beach, FL to University of Florida - 1956 Gale Lemerand Drbus
9h 37m$84–168Bus via North Walmart Supercenter (Greyhound)
- Take the bus from Key Largo Bus Stop to Miami Airport Stationbus Greyhound US0720s
- Take the bus from Miami Airport Station to Gainesville Bus Stopbus Greyhound US0630 / ...
12h 3m$61–119
Key Largo to Gainesville by bus
Comparing Your Travel Options
The cheapest way to get from Key Largo to Gainesville is to bus via North Walmart Supercenter which costs $60 - $120 and takes 12h 3m.
The fastest way to get from Key Largo to Gainesville is to bus and fly which takes 5h and costs $50 - $300.
No, there is no direct bus from Key Largo to Gainesville. However, there are services departing from Key Largo Bus Stop and arriving at Gainesville via Miami Airport Station. The journey, including transfers, takes approximately 9h 5m.
The distance between Key Largo and Gainesville is 364 miles. The road distance is 379.6 miles.
The best way to get from Key Largo to Gainesville without a car is to bus which takes 9h 5m and costs $55 - $110.
It takes approximately 5h to get from Key Largo to Gainesville, including transfers.
Key Largo to Gainesville bus services, operated by Greyhound USA, depart from Key Largo Bus Stop station.
Key Largo to Gainesville bus services, operated by Greyhound USA, arrive at Miami Airport Station.
Yes, the driving distance between Key Largo to Gainesville is 380 miles. It takes approximately 7h 6m to drive from Key Largo to Gainesville.
Book your Key Largo to Gainesville bus tickets online with Omio and FlixBus.
What companies run services between Key Largo, FL, USA and Gainesville, FL, USA?
You can take a bus from Key Largo Bus Stop to Gainesville via Miami Airport Station in around 9h 5m.
- Website
- aa.com
Flights from Miami International Airport to Gainesville Regional Airport
- Ave. Duration
- 1h 19m
- When
- Every day
- Estimated price
- $40–280
Flights from Miami International Airport to Orlando
- Ave. Duration
- 1h 18m
- When
- Every day
- Estimated price
- $35–260
Flights from Miami International Airport to Jacksonville
- Ave. Duration
- 1h 26m
- When
- Every day
- Estimated price
- $50–330
Flights from Miami International Airport to Tampa
- Ave. Duration
- 1h 12m
- When
- Every day
- Estimated price
- $40–280
Flights from Miami International Airport to Tallahassee
- Ave. Duration
- 1h 33m
- When
- Every day
- Estimated price
- $65–390
- Website
- southwest.com
Flights from Miami International Airport to Orlando
- Ave. Duration
- 1h 10m
- When
- Every day
- Estimated price
- $35–260
Flights from Fort Lauderdale–Hollywood International Airport to Orlando
- Ave. Duration
- 1h 9m
- When
- Every day
- Estimated price
- $35–270
- Website
- jetblue.com
Flights from Fort Lauderdale–Hollywood International Airport to Orlando
- Ave. Duration
- 1h 7m
- When
- Every day
- Estimated price
- $35–270
Flights from Fort Lauderdale–Hollywood International Airport to Jacksonville
- Ave. Duration
- 1h 19m
- When
- Every day
- Estimated price
- $55–340
- Website
- flybreeze.com
Flights from Fort Lauderdale–Hollywood International Airport to Jacksonville
- Ave. Duration
- 1h 25m
- When
- Every day
- Estimated price
- $120–650
- Phone
- +1 831-539-2901
- guestservices@gobrightline.com
- Website
- gobrightline.com
Train from Miami to Orlando
- Ave. Duration
- 3h 34m
- Frequency
- Every 2 hours
- Estimated price
- $40–170
- Book at
- Brightline
- Smart
- $40–90
- Premium
- $110–170
- Phone
- +1 800-874-7245
- Tri-RailCustomerExperience@sfrta.fl.gov
- Website
- Tri Rail
Train from Miami Airport Station to West Palm Beach Station
- Ave. Duration
- 1h 45m
- Frequency
- Hourly
- Estimated price
- $5–11
- Website
- Tri Rail
- Weekend | Holiday
- $5
- Weekday
- $8–11
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- ifsr@greyhound.com
- Website
- Greyhound
Bus from Key Largo Bus Stop to Miami Airport Station
- Ave. Duration
- 1h 15m
- Frequency
- 5 times a day
- Estimated price
- $8–17
- Website
- Greyhound
Bus from Key Largo Bus Stop to Miami Airport Station
- Ave. Duration
- 1h 15m
- Frequency
- 5 times a day
- Estimated price
- $8–17
- Website
- Greyhound
Bus from Key Largo Bus Stop to Miami Airport Station
- Ave. Duration
- 1h 15m
- Frequency
- 5 times a day
- Estimated price
- $8–17
- Website
- Greyhound
Bus from Key Largo Bus Stop to Miami Airport Station
- Ave. Duration
- 1h 15m
- Frequency
- 5 times a day
- Estimated price
- $8–17
- Website
- Greyhound
Bus from Key Largo Bus Stop to Miami Airport Station
- Ave. Duration
- 1h 15m
- Frequency
- 5 times a day
- Estimated price
- $8–17
- Website
- Greyhound
Bus from Key Largo Bus Stop to Miami Airport Station
- Ave. Duration
- 1h 15m
- Frequency
- 5 times a day
- Estimated price
- $8–17
- Website
- Greyhound
Bus from Key Largo Bus Stop to Miami Airport Station
- Ave. Duration
- 1h 15m
- Frequency
- 5 times a day
- Estimated price
- $8–17
- Website
- Greyhound
Bus from Key Largo Bus Stop to Miami Airport Station
- Ave. Duration
- 1h 15m
- Frequency
- 5 times a day
- Estimated price
- $8–17
- Website
- Greyhound
Bus from Key Largo Bus Stop to Miami Airport Station
- Ave. Duration
- 1h 15m
- Frequency
- 5 times a day
- Estimated price
- $8–17
- Website
- Greyhound
Bus from Miami Airport Station to Gainesville Bus Stop
- Ave. Duration
- 8h 25m
- Frequency
- 4 times a day
- Estimated price
- $50–100
- Website
- Greyhound
- Phone
- +1 (855) 626-8585
- Website
- Flixbus USA
Bus from Miami Airport Station to Gainesville
- Ave. Duration
- 6h 50m
- Frequency
- 3 times a day
- Estimated price
- $50–90
- Schedules at
- Flixbus USA
Bus from Jacksonville to Gainesville
- Ave. Duration
- 1h 29m
- Frequency
- Once daily
- Estimated price
- $10–18
- Schedules at
- Flixbus USA
Bus from Jacksonville to Gainesville
- Ave. Duration
- 1h 29m
- Frequency
- Once daily
- Estimated price
- $10–18
- Schedules at
- Flixbus USA
Bus from Tampa Bus Station to Gainesville
- Ave. Duration
- 2h 35m
- Frequency
- Twice daily
- Estimated price
- $20–35
- Schedules at
- Flixbus USA
Bus from Tallahassee to Gainesville
- Ave. Duration
- 2h 35m
- Frequency
- Once daily
- Estimated price
- $23–40
- Schedules at
- Flixbus USA
- Phone
- +1 877 733 0724
- Website
- RedCoach
Bus from Orlando - RedCoach Station, FL to University of Florida - 1956 Gale Lemerand Dr
- Ave. Duration
- 2h 20m
- Frequency
- 4 times a day
- Estimated price
- $29–60
- Website
- RedCoach
Bus from Orlando - RedCoach Station, FL to University of Florida - 1956 Gale Lemerand Dr
- Ave. Duration
- 2h 20m
- Frequency
- 4 times a day
- Estimated price
- $29–60
- Website
- RedCoach
Bus from Orlando - RedCoach Station, FL to University of Florida - 1956 Gale Lemerand Dr
- Ave. Duration
- 2h 20m
- Frequency
- 4 times a day
- Estimated price
- $29–60
- Website
- RedCoach
Bus from West Palm Beach, FL to University of Florida - 1956 Gale Lemerand Dr
- Ave. Duration
- 5h 5m
- Frequency
- 4 times a day
- Estimated price
- $70–140
- Website
- RedCoach
- Phone
- +1 (305) 289-9997
- groups@keysshuttle.com
- Website
- Keys Shuttle
Shuttle from Key Largo, FL to Fort Lauderdale, FL - International Airport
- Ave. Duration
- 1h 45m
- Frequency
- 3 times a day
- Estimated price
- $120–150
- Website
- Keys Shuttle
Shuttle from Key Largo, FL to Fort Lauderdale, FL - International Airport
- Ave. Duration
- 1h 45m
- Frequency
- 3 times a day
- Estimated price
- $120–150
- Website
- Keys Shuttle
Want to know more about travelling around United States
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Travelling to the US: What do I need to know?
Read the travel guide
Need to know: Greyhound
Read the travel guide
Booking & Getting There
There are 249+ hotels available in Gainesville.













