There are 5 ways to get from Jacksonville to South Carolina by bus, train, car or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Bus  •  6 h 25 min

  1. Take the bus from Jacksonville, Fl to Florence, Sc 1008

$30 - $85

4 alternative options

Train  •  7 h 27 min

  1. Take the train from Jacksonville Amtrak to Florence Amtrak Silver Meteor

$56 - $152

Drive  •  5 h 3 min

  1. Drive from Jacksonville to Florence 310 miles

$30 - $45

Fly to Charlotte  •  3 h 48 min

  1. Fly from Jacksonville (JAX) to Charlotte (CLT) JAX - CLT

$186 - $742

Fly to Greenville/Spartanburg  •  5 h 10 min

  1. Fly from Jacksonville (JAX) to Greenville/Spartanburg (GSP) JAX - GSP

$162 - $746

Questions & Answers

The cheapest way to get from Jacksonville to South Carolina is to drive which costs $30 - $45 and takes 5 h 3 min.

More details

The quickest way to get from Jacksonville to South Carolina is to fly which takes 3 h 48 min and costs $180 - $750.

More details

The distance between Jacksonville and South Carolina is 390 km. The road distance is 496 km.

Get driving directions

The bus from Jacksonville, Fl to Florence, Sc takes 6 h 25 min including transfers and departs hourly.

More details

Yes, there is a direct bus departing from Jacksonville, Fl and arriving at Florence, Sc. Services depart hourly, and operate every day. The journey takes approximately 6 h 25 min.

More details

What companies run services between Jacksonville, FL, USA and South Carolina, USA?

Greyhound USA operates a bus from Jacksonville to Florence hourly. Tickets cost $30 - $85 and the journey takes 6 h 25 min. Alternatively, Amtrak operates a train from Jacksonville to Florence once daily. Tickets cost $55 - $150 and the journey takes 5 h 55 min.

Airlines
American Airlines
Website
aa.com
Flights from Jacksonville to Charlotte
Ave. Duration
1 h 30 min
When
Every day
Estimated price
$110 - $600
Flights from Jacksonville to Greenville/Spartanburg via Charlotte
Ave. Duration
3 h 43 min
When
Every day
Estimated price
$140 - $750
Flights from Jacksonville to Greenville/Spartanburg via Reagan Washington
Ave. Duration
4 h 26 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$180 - $800
Delta
Website
delta.com
Flights from Jacksonville to Charlotte via Atlanta
Ave. Duration
3 h 32 min
When
Every day
Estimated price
$110 - $650
Flights from Jacksonville to Greenville/Spartanburg via Atlanta
Ave. Duration
3 h 31 min
When
Every day
Estimated price
$130 - $700
Southwest Airlines
Website
southwest.com
Flights from Jacksonville to Charlotte via Nashville
Ave. Duration
3 h 30 min
When
Sunday
Estimated price
$150 - $650
Flights from Jacksonville to Greenville/Spartanburg via Atlanta
Ave. Duration
4 h 17 min
When
Every day
Estimated price
$150 - $700
United Airlines
Website
united.com
Flights from Jacksonville to Greenville/Spartanburg via Washington Dulles
Ave. Duration
4 h 36 min
When
Every day
Estimated price
$190 - $850
Train operators
Amtrak
Phone
+1 1-800-872-7245
Website
amtrak.com
Train from Jacksonville Amtrak to Florence Amtrak
Ave. Duration
5 h 55 min
Frequency
Once daily
Estimated price
$55 - $150
Website
amtrak.com
Coach Seat
$55 - $85
Flexi Coach Seat
$100 - $150
Business Coach Seat
$100 - $150
Room
$260 - $360
Bus operators
Greyhound USA
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from Jacksonville, Fl to Florence, Sc
Ave. Duration
6 h 25 min
Frequency
Hourly
Estimated price
$30 - $85
Website
greyhound.com
Economy
$30 - $55
Flexible
$65 - $85

Want to know more about travelling around United States

Rome2rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.