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There are 5 ways to get from Jacksonville to South Carolina by bus, train, car or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Bus  •  6 h 25 min

  1. Take the bus from Jacksonville, Fl to Florence, Sc 1008

$30 - $85

4 alternative options

Train  •  7 h 27 min

  1. Take the train from Jacksonville Amtrak Station to Florence Amtrak Station Silver Meteor

$56 - $152

Drive  •  5 h 3 min

  1. Drive from Jacksonville to Florence 310 miles

$30 - $45

Fly to Columbia  •  5 h 1 min

  1. Fly from Jacksonville (JAX) to Columbia (CAE) JAX - CAE

$186 - $882

Fly to Charlotte, bus  •  6 h 4 min

  1. Fly from Jacksonville (JAX) to Charlotte (CLT) JAX - CLT
  2. Take the bus from Transit Center- Bay X to White Street Park and Ride

$118 - $660

Questions & Answers

The cheapest way to get from Jacksonville to South Carolina is to drive which costs $30 - $45 and takes 5 h 3 min.

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The quickest way to get from Jacksonville to South Carolina is to fly which costs $180 - $900 and takes 5 h 1 min.

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Yes, there is a direct bus departing from Jacksonville, Fl and arriving at Florence, Sc. Services depart three times a day, and operate every day. The journey takes approximately 6 h 25 min.

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The distance between Jacksonville and South Carolina is 244 miles. The road distance is 310 miles.

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The best way to get from Jacksonville to South Carolina without a car is to bus which takes 6 h 25 min and costs $30 - $85.

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The bus from Jacksonville, Fl to Florence, Sc takes 6 h 25 min including transfers and departs three times a day.

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Jacksonville to South Carolina bus services, operated by Greyhound USA, depart from Jacksonville, Fl station.

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The best way to get from Jacksonville to South Carolina is to bus which takes 6 h 25 min and costs $30 - $85. Alternatively, you can train, which costs $55 - $160 and takes 7 h 27 min, you could also fly, which costs $180 - $900 and takes 5 h 1 min.

Mode details

There is no direct flight from Jacksonville Airport to Columbia Airport. The quickest flight takes 3 h 1 min and has one stopover.

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Jacksonville to South Carolina bus services, operated by Greyhound USA, arrive at Florence, Sc station.

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Map of how to get from Jacksonville to South Carolina.
Launch map view
  • Distance: 244 miles
  • Duration: 6 h 25 min

What companies run services between Jacksonville, FL, USA and South Carolina, USA?

Greyhound USA operates a bus from Jacksonville to Florence 3 times a day. Tickets cost $30 - $85 and the journey takes 6 h 25 min. Alternatively, Amtrak operates a train from Jacksonville to Florence once daily. Tickets cost $55 - $150 and the journey takes 5 h 55 min.

Airlines
American Airlines
Website
aa.com
Flights from Jacksonville to Columbia via Charlotte
Ave. Duration
3 h 44 min
When
Every day
Estimated price
$170 - $850
Flights from Jacksonville to Columbia via Reagan Washington
Ave. Duration
4 h 42 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$220 - $950
Flights from Jacksonville to Columbia via Philadelphia
Ave. Duration
6 h 12 min
When
Every day
Estimated price
$230 - $1,000
Flights from Jacksonville to Charlotte
Ave. Duration
1 h 28 min
When
Every day
Estimated price
$110 - $600
Delta
Website
delta.com
Flights from Jacksonville to Columbia via Atlanta
Ave. Duration
3 h 43 min
When
Every day
Estimated price
$160 - $850
Flights from Jacksonville to Columbia via New York La Guardia
Ave. Duration
5 h 46 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$230 - $1,100
Flights from Jacksonville to Charlotte via Atlanta
Ave. Duration
3 h 36 min
When
Every day
Estimated price
$110 - $650
United Airlines
Website
united.com
Flights from Jacksonville to Columbia via Washington Dulles
Ave. Duration
4 h 37 min
When
Every day
Estimated price
$220 - $1,000
Flights from Jacksonville to Columbia via Houston
Ave. Duration
6 h 42 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$270 - $1,200
Train operators
Amtrak

Amtrak is a rail service that connects the US and three Canadian provinces. Covering 21,000 route miles (34,000km) Amtrak operates more than 300 trains daily. These medium and long distance intercity services operate at speeds of up to 240km/h, to more than 500 destinations. Founded in 1971, it is based in Washington, D.C. and offers four classes of travel: First Class, Sleeper, Business and Coach. Ticket fares are divided into five subclasses: Saver, Value, Flexible, Business and Premium. Amtrak trains are known for their wide seats, plug-in power, big windows and storage capabilities.

Rome2rio's guide to Amtrak
Contact Details
Phone
+1 215-856-7924
Website
amtrak.com
Train from Jacksonville Amtrak Station to Florence Amtrak Station
Ave. Duration
5 h 55 min
Frequency
Once daily
Estimated price
$55 - $150
Website
amtrak.com
Coach Seat
$55 - $85
Flexi Coach Seat
$100 - $150
Business Coach Seat
$100 - $150
Room
$260 - $360
Bus operators
Greyhound USA

Greyhound is a leading bus company based in Dallas, Texas, serving over 3800 destinations across North America, Mexico and Canada. Greyhound carries around 18 million passengers a year who travel 5.4 billion miles (8.6 billion km) a year on their fleet of around 1700 vehicles. For travel flexibility, you can board or get off a Greyhound bus at official Greyhound stations, partner stations and curbside stops. There are around 230 Greyhound stations across the US where you can both catch your bus and buy tickets, that are also available on the official website and via the mobile app.

Rome2rio's guide to Greyhound USA
Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from Jacksonville, Fl to Florence, Sc
Ave. Duration
6 h 25 min
Frequency
3 times a day
Estimated price
$30 - $85
Website
greyhound.com
Economy
$30 - $55
Flexible
$65 - $85
Charlotte Area Transit System
Phone
+1 704-336-7433
Email
telltransit@charlottenc.gov
Website
charlottenc.gov
Bus from Transit Center- Bay X to White Street Park and Ride
Ave. Duration
1 h 12 min
Frequency
3 times a day
Estimated price
$3 - $5
Schedules at
charlottenc.gov

Want to know more about travelling around United States

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More Questions & Answers

Yes, the driving distance between Jacksonville to South Carolina is 310 miles. It takes approximately 5 h 3 min to drive from Jacksonville to South Carolina.

Get driving directions

United Airlines, Delta and American Airlines offer flights from Jacksonville Airport to Columbia Airport.

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Book your Jacksonville to South Carolina bus tickets online with Greyhound.

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There are 17+ hotels available in South Carolina. Prices start at $49 USD per night.

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The best way to get from Jacksonville to Jacksonville Airport is to line 1 bus which takes 49 min and costs $1 - $2.

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