There are 5 ways to get from Jacksonville to South Carolina by plane, bus, train or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly to Charlotte  •  3 h 42 min

  1. Fly from Jacksonville (JAX) to Charlotte (CLT) JAX - CLT

$186 - $742

Cheapest option

Bus  •  6 h 25 min

  1. Take the bus from Jacksonville, Fl to Florence, Sc 1008

$30 - $85

3 alternative options

Fly to Greenville/Spartanburg  •  4 h 56 min

  1. Fly from Jacksonville (JAX) to Greenville/Spartanburg (GSP) JAX - GSP

$162 - $746

Train  •  7 h 27 min

  1. Take the train from Jacksonville Amtrak to Florence Amtrak Silver Meteor

$56 - $152

Drive  •  5 h 3 min

  1. Drive from Jacksonville to Florence 310 miles

$30 - $45

Questions & Answers

The cheapest way to get from Jacksonville to South Carolina is to drive which costs $30 - $45 and takes 5 h 3 min.

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The quickest way to get from Jacksonville to South Carolina is to fly which costs $180 - $750 and takes 3 h 42 min.

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Yes, there is a direct bus departing from Jacksonville, Fl and arriving at Florence, Sc. Services depart hourly, and operate every day. The journey takes approximately 6 h 25 min.

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The distance between Jacksonville and South Carolina is 244 miles. The road distance is 310 miles.

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The best way to get from Jacksonville to South Carolina without a car is to bus which takes 6 h 25 min and costs $30 - $85.

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It takes approximately 3 h 42 min to get from Jacksonville to South Carolina, including transfers.

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Jacksonville to South Carolina bus services, operated by Greyhound USA, depart from Jacksonville, Fl station.

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The best way to get from Jacksonville to South Carolina is to fly which takes 3 h 42 min and costs $180 - $750. Alternatively, you can bus, which costs $30 - $85 and takes 6 h 25 min, you could also train, which costs $55 - $160 and takes 7 h 27 min.

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The quickest flight from Jacksonville Airport to Charlotte Airport is the direct flight which takes 1 h 20 min.

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Jacksonville to South Carolina bus services, operated by Greyhound USA, arrive at Florence, Sc station.

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Map of how to get from Jacksonville to South Carolina.
Launch map view
  • Distance: 244 miles
  • Duration: 3 h 42 min

What companies run services between Jacksonville, FL, USA and South Carolina, USA?

American Airlines and Delta fly from Jacksonville to Rock Hill every 2 hours. Alternatively, Greyhound USA operates a bus from Jacksonville to Florence hourly. Tickets cost $30 - $85 and the journey takes 6 h 25 min.

Airlines
American Airlines
Website
aa.com
Flights from Jacksonville to Charlotte
Ave. Duration
1 h 28 min
When
Every day
Estimated price
$110 - $600
Flights from Jacksonville to Greenville/Spartanburg via Charlotte
Ave. Duration
3 h 25 min
When
Every day
Estimated price
$140 - $750
Flights from Jacksonville to Greenville/Spartanburg via Philadelphia
Ave. Duration
5 h 3 min
When
Monday, Tuesday, Thursday and Friday
Estimated price
$190 - $850
Delta
Website
delta.com
Flights from Jacksonville to Charlotte via Atlanta
Ave. Duration
3 h 33 min
When
Every day
Estimated price
$110 - $650
Flights from Jacksonville to Greenville/Spartanburg via Atlanta
Ave. Duration
3 h 48 min
When
Every day
Estimated price
$130 - $700
Southwest Airlines
Website
southwest.com
Flights from Jacksonville to Greenville/Spartanburg via Atlanta
Ave. Duration
3 h 57 min
When
Every day
Estimated price
$150 - $700
United Airlines
Website
united.com
Flights from Jacksonville to Greenville/Spartanburg via Washington Dulles
Ave. Duration
4 h 30 min
When
Every day
Estimated price
$190 - $850
Flights from Jacksonville to Greenville/Spartanburg via Newark
Ave. Duration
5 h 16 min
When
Every day
Estimated price
$210 - $950
Train operators
Amtrak

Amtrak is a rail service that connects the US and three Canadian provinces. Covering 21,000 route miles (34,000km) Amtrak operates more than 300 trains daily. These medium and long distance intercity services operate at speeds of up to 240km/h, to more than 500 destinations. Founded in 1971, it is based in Washington, D.C. and offers four classes of travel: First Class, Sleeper, Business and Coach. Ticket fares are divided into five subclasses: Saver, Value, Flexible, Business and Premium. Amtrak trains are known for their wide seats, plug-in power, big windows and storage capabilities.

Rome2rio's guide to Amtrak
Contact Details
Phone
+1 1-800-872-7245
Website
amtrak.com
Train from Jacksonville Amtrak to Florence Amtrak
Ave. Duration
5 h 55 min
Frequency
Once daily
Estimated price
$55 - $150
Website
amtrak.com
Coach Seat
$55 - $85
Flexi Coach Seat
$100 - $150
Business Coach Seat
$100 - $150
Room
$260 - $360
Bus operators
Greyhound USA

Greyhound is a leading bus company based in Dallas, Texas, serving over 3800 destinations across North America, Mexico and Canada. Greyhound carries around 18 million passengers a year who travel 5.4 billion miles (8.6 billion km) a year on their fleet of around 1700 vehicles. For travel flexibility, you can board or get off a Greyhound bus at official Greyhound stations, partner stations and curbside stops. There are around 230 Greyhound stations across the US where you can both catch your bus and buy tickets, that are also available on the official website and via the mobile app.

Rome2rio's guide to Greyhound USA
Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from Jacksonville, Fl to Florence, Sc
Ave. Duration
6 h 25 min
Frequency
Hourly
Estimated price
$30 - $85
Website
greyhound.com
Economy
$30 - $55
Flexible
$65 - $85

Want to know more about travelling around United States

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More Questions & Answers

Yes, the driving distance between Jacksonville to South Carolina is 310 miles. It takes approximately 5 h 3 min to drive from Jacksonville to South Carolina.

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Delta and American Airlines offer flights from Jacksonville Airport to Charlotte Airport.

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Book your Jacksonville to South Carolina bus tickets online with Greyhound.

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There are 16+ hotels available in South Carolina. Prices start at $52 USD per night.

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The best way to get from Jacksonville to Jacksonville Airport is to line 1 bus which takes 49 min and costs $2.

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