There are 10 ways to get from Ithaca to Indiana by bus, plane, train, bus (Flixbus), car, or bus (Greyhound)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Bus to Rochester, fly to Chicago Midway International Airport, train
best- Take the bus from Ithaca to Rochester, Nybus
- Fly from Rochester (ROC) to Chicago Midway International Airport (MDW)plane ROC - MDW
- Take the train from Van Buren St. to Gary Metro Centertrain
6h 40m$140–642Bus to Elmira/Corning Regional Airport, fly to South Bend, train
cheapest- Take the bus from Ithaca - Tioga Street and Seneca Street to Transit Center - PO Sidebus
- Fly from Elmira/Corning Regional Airport (ELM) to South Bend (SBN)plane ELM - SBN
- Take the train from South Bend Airport to Gary Metro Centertrain
13h 26m$77–381Bus, train via Toledo
- Take the bus from Ithaca to Rochester, Nybus 246
- Take the train from Rochester to Toledotrain
- Take the bus from Toledo to Indianapolisbus
14h 39m$232–429Bus
- Take the bus from Ithaca to Buffalobus
- Take the bus from Buffalo to Columbusbus
- Take the bus from Columbus to Indianapolisbus
15h 45m$104–164Drive 621.4 mi
- Drive from Ithaca to Indianapoliscar 621.4 mi
11h 13m$114–164Bus to Rochester, fly to Chicago O'Hare International Airport, train
- Take the bus from Ithaca to Rochester, Nybus
- Fly from Rochester (ROC) to Chicago O'Hare International Airport (ORD)plane ROC - ORD
- Take the train from Van Buren St. to Gary Metro Centertrain
7h 6m$120–502Bus to Buffalo Niagara International Airport, fly to Chicago Midway International Airport, train
- Take the bus from Ithaca to Buffalobus
- Fly from Buffalo Niagara International Airport (BUF) to Chicago Midway International Airport (MDW)plane BUF - MDW
- Take the train from Van Buren St. to Gary Metro Centertrain
8h 5m$195–422Bus to Syracuse Hancock International Airport, fly to Chicago O'Hare International Airport, train
- Take the bus from Ithaca to Syracuse Bus Stationbus
- Fly from Syracuse Hancock International Airport (SYR) to Chicago O'Hare International Airport (ORD)plane SYR - ORD
- Take the train from Van Buren St. to Gary Metro Centertrain
7h 43m$98–476Bus, train
- Take the bus from Ithaca to Syracuse Bus Stationbus
- Take the train from Syracuse Regional Transportation Center to Chicago Union Stationtrain
- Take the train from Chicago Union Station to Indianapolistrain
21h 16m$470–784Bus via New York
- Take the bus from Ithaca, NY to New York, NYbus
- Take the bus from Willow Ave At 15Th St to Port Authority Bus Terminalbus 126 / ...
- Take the bus from Port Authority Bus Terminal to Indianapolis Union Stationbus
22h 40m$219–397
Ithaca to Indiana by bus and train
Comparing Your Travel Options
The cheapest way to get from Ithaca to Indiana is to bus which costs $100 - $170 and takes 15h 45m.
The fastest way to get from Ithaca to Indiana is to bus and fly and train which takes 6h 40m and costs $140 - $650.
No, there is no direct bus from Ithaca to Indiana. However, there are services departing from Ithaca and arriving at Indianapolis via Buffalo and Columbus. The journey, including transfers, takes approximately 15h 45m.
The distance between Ithaca and Indiana is 662 miles. The road distance is 625.1 miles.
The best way to get from Ithaca to Indiana without a car is to bus and train via Toledo which takes 14h 39m and costs $230 - $430.
It takes approximately 6h 40m to get from Ithaca to Indiana, including transfers.
Ithaca to Indiana bus services, operated by Trailways, depart from Ithaca station.
Ithaca to Indiana bus services, operated by Trailways, arrive at Buffalo station.
Yes, the driving distance between Ithaca to Indiana is 625 miles. It takes approximately 11h 13m to drive from Ithaca to Indiana.
Book your Ithaca to Indiana bus tickets online with Omio and FlixBus.
What companies run services between Ithaca, NY, USA and Indiana, USA?
You can take a bus from Ithaca to Indianapolis via Buffalo and Columbus in around 15h 45m.
- Website
- southwest.com
Flights from Rochester to Chicago Midway International Airport
- Ave. Duration
- 1h 50m
- When
- Every day
- Estimated price
- $90–550
Flights from Rochester to Chicago Midway International Airport via Baltimore
- Ave. Duration
- 4h 25m
- When
- Saturday, Monday, Thursday, and Friday
- Estimated price
- $120–650
Flights from Buffalo Niagara International Airport to Chicago Midway International Airport
- Ave. Duration
- 1h 40m
- When
- Every day
- Estimated price
- $60–370
Flights from Buffalo Niagara International Airport to Chicago Midway International Airport via Baltimore
- Ave. Duration
- 4h 11m
- When
- Monday to Saturday
- Estimated price
- $90–450
- Website
- united.com
Flights from Rochester to Chicago O'Hare International Airport
- Ave. Duration
- 2h 14m
- When
- Every day
- Estimated price
- $70–410
Flights from Rochester to Chicago O'Hare International Airport via Washington Dulles
- Ave. Duration
- 4h 34m
- When
- Every day
- Estimated price
- $90–480
Flights from Syracuse Hancock International Airport to Chicago O'Hare International Airport
- Ave. Duration
- 2h 31m
- When
- Every day
- Estimated price
- $75–420
Flights from Syracuse Hancock International Airport to Chicago O'Hare International Airport via Washington Dulles
- Ave. Duration
- 4h 38m
- When
- Every day
- Estimated price
- $95–480
- Website
- delta.com
Flights from Rochester to Chicago Midway International Airport via Detroit
- Ave. Duration
- 4h 7m
- When
- Every day
- Estimated price
- $90–550
Flights from Rochester to Chicago O'Hare International Airport via Detroit
- Ave. Duration
- 4h 34m
- When
- Every day
- Estimated price
- $70–410
Flights from Buffalo Niagara International Airport to Chicago Midway International Airport via Detroit
- Ave. Duration
- 4h 17m
- When
- Every day
- Estimated price
- $60–370
Flights from Syracuse Hancock International Airport to Chicago O'Hare International Airport via Detroit
- Ave. Duration
- 4h 10m
- When
- Every day
- Estimated price
- $75–420
Flights from Elmira/Corning Regional Airport to South Bend via Detroit
- Ave. Duration
- 10h 20m
- When
- Every day
- Estimated price
- $60–360
- Website
- aa.com
Flights from Rochester to Chicago O'Hare International Airport
- Ave. Duration
- 2h 12m
- When
- Every day
- Estimated price
- $70–410
Flights from Syracuse Hancock International Airport to Chicago O'Hare International Airport
- Ave. Duration
- 2h 26m
- When
- Every day
- Estimated price
- $75–420
- Phone
- +1 219-926-5744
- Website
- mysouthshoreline.com
Train from Van Buren St. to Gary Metro Center
- Ave. Duration
- 51 min
- Frequency
- Every 30 minutes
- Estimated price
- $8–10
- Schedules at
- mysouthshoreline.com
- Adults 14-64
- $8–10
Train from Van Buren St. to Gary Metro Center
- Ave. Duration
- 51 min
- Frequency
- Every 30 minutes
- Estimated price
- $8–10
- Schedules at
- mysouthshoreline.com
- Adults 14-64
- $8–10
Train from Van Buren St. to Gary Metro Center
- Ave. Duration
- 51 min
- Frequency
- Every 30 minutes
- Estimated price
- $8–10
- Schedules at
- mysouthshoreline.com
- Adults 14-64
- $8–10
Train from Van Buren St. to Gary Metro Center
- Ave. Duration
- 51 min
- Frequency
- Every 30 minutes
- Estimated price
- $8–10
- Schedules at
- mysouthshoreline.com
- Adults 14-64
- $8–10
Train from South Bend Airport to Gary Metro Center
- Ave. Duration
- 1h 11m
- Frequency
- Every 4 hours
- Estimated price
- $11–13
- Schedules at
- mysouthshoreline.com
- Adults 14-64
- $11–13
Train from Van Buren St. to Gary Metro Center
- Ave. Duration
- 51 min
- Frequency
- Hourly
- Estimated price
- $4–9
- Schedules at
- Northern Indiana Commuter Transportation District
Train from Van Buren St. to Gary Metro Center
- Ave. Duration
- 51 min
- Frequency
- Hourly
- Estimated price
- $4–9
- Schedules at
- Northern Indiana Commuter Transportation District
Train from Van Buren St. to Gary Metro Center
- Ave. Duration
- 51 min
- Frequency
- Hourly
- Estimated price
- $4–9
- Schedules at
- Northern Indiana Commuter Transportation District
Train from Van Buren St. to Gary Metro Center
- Ave. Duration
- 51 min
- Frequency
- Hourly
- Estimated price
- $4–9
- Schedules at
- Northern Indiana Commuter Transportation District
Train from South Bend Airport to Gary Metro Center
- Ave. Duration
- 1h 11m
- Frequency
- 4 times a day
- Estimated price
- $3–14
- Schedules at
- Northern Indiana Commuter Transportation District
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from Rochester to Toledo
- Ave. Duration
- 6h 44m
- Frequency
- Twice daily
- Estimated price
- $190–310
- Website
- Amtrak
Train from Syracuse Regional Transportation Center to Chicago Union Station
- Ave. Duration
- 13h 7m
- Frequency
- Twice daily
- Estimated price
- $360–600
- Website
- Amtrak
Train from Chicago Union Station to Indianapolis
- Ave. Duration
- 4h 54m
- Frequency
- 3 times a week
- Estimated price
- $100–170
- Website
- Amtrak
- Phone
- +1 800-858-8555
- Website
- Trailways
Bus from Ithaca to Rochester, Ny
- Saver
- $20–55
- Flexible
- $40–55
Bus from Ithaca to Rochester, Ny
- Saver
- $20–55
- Flexible
- $40–55
Bus from Ithaca to Buffalo
- Saver
- $29–95
- Flexible
- $55–100
Bus from Ithaca to Rochester, Ny
- Saver
- $20–55
- Flexible
- $40–55
Bus from Ithaca to Buffalo
- Saver
- $28–90
- Flexible
- $55–95
- Phone
- +1 888-378-3823
- info@baronsbus.com
- Website
- Barons Bus
Bus from Toledo to Indianapolis
- Ave. Duration
- 4h 5m
- Frequency
- Once daily
- Estimated price
- $21–65
- Website
- Barons Bus
- Phone
- +1 (855) 626-8585
- Website
- Flixbus USA
Bus from Ithaca to Buffalo
- Ave. Duration
- 3h 45m
- Frequency
- Twice daily
- Estimated price
- $26–40
- Schedules at
- Flixbus USA
Bus from Buffalo to Columbus
- Ave. Duration
- 6h 25m
- Frequency
- Once daily
- Estimated price
- $50–80
- Schedules at
- Flixbus USA
Bus from Columbus to Indianapolis
- Ave. Duration
- 3h 30m
- Frequency
- Twice daily
- Estimated price
- $28–45
- Schedules at
- Flixbus USA
Bus from Ithaca to Buffalo
- Ave. Duration
- 3h 25m
- Frequency
- Twice daily
- Estimated price
- $24–40
- Schedules at
- Flixbus USA
Bus from Ithaca to Syracuse Bus Station
- Ave. Duration
- 1h 15m
- Frequency
- 3 times a week
- Estimated price
- $9–15
- Schedules at
- Flixbus USA
Bus from Ithaca to Syracuse Bus Station
- Ave. Duration
- 1h 15m
- Frequency
- 3 times a week
- Estimated price
- $9–15
- Schedules at
- Flixbus USA
- Phone
- +1 607-734-5211
- Website
- CTran
Bus from Ithaca - Tioga Street and Seneca Street to Transit Center - PO Side
- Ave. Duration
- 55 min
- Frequency
- Once daily
- Estimated price
- $3–6
- Website
- CTran
- Phone
- +1-844-800-6828
- pr@ourbus.com
- Website
- OurBus
Bus from Ithaca, NY to New York, NY
- Ave. Duration
- 4h 20m
- Frequency
- 5 times a day
- Estimated price
- $70–170
- Website
- OurBus
- Phone
- +1 973-275-5555
- Website
- New Jersey Transit
Bus from Willow Ave At 15Th St to Port Authority Bus Terminal
- Ave. Duration
- 14 min
- Frequency
- Every 5 minutes
- Estimated price
- $7–23
- Website
- New Jersey Transit
- Website
- NJ Transit: World Cup 2026
- Adults
- $7–23
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- ifsr@greyhound.com
- Website
- Greyhound
Bus from Port Authority Bus Terminal to Indianapolis Union Station
- Ave. Duration
- 17h 5m
- Frequency
- 3 times a day
- Estimated price
- $140–210
- Website
- Greyhound
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