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How to get fromIthaca, NY to Chicagoby bus, plane, train, bus (Flixbus, Greyhound) or car

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There are 9 ways to get from Ithaca, NY to Chicago by bus, plane, train, bus (Flixbus, Greyhound), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Syracuse Hancock International Airport, fly to Chicago O'Hare International Airport

    best
    1. Take the bus from Ithaca, NY to Syracuse Airport, NYbus bus
    2. Fly from Syracuse Hancock International Airport (SYR) to Chicago O'Hare International Airport (ORD)plane plane SYR - ORD
    6h 6m
    $102–517

  2. Bus

    cheapest
    1. Take the bus from Ithaca to Buffalobus bus
    2. Take the bus from Buffalo to Cleveland Bus Stationbus bus
    3. Take the bus from Cleveland Bus Station to Chicago Bus Stationbus bus
    16h 53m
    $84–227

  3. Bus, train

    1. Take the bus from Ithaca to Rochester, Nybus bus 246 / ...
    2. Take the train from Rochester to Chicago Union Stationtrain train Lake Shore Limited
    14h 36m
    $91–264

  4. Drive 658.3 mi

    1. Drive from Ithaca, NY to Chicagocar car 658.3 mi
    11h 42m
    $121–174

  5. Bus to Rochester, fly to Chicago O'Hare International Airport

    1. Take the bus from Ithaca, NY to Rochester, NYbus bus
    2. Fly from Rochester (ROC) to Chicago O'Hare International Airport (ORD)plane plane ROC - ORD
    6h 28m
    $132–551

  6. Bus to Rochester, fly to Chicago Midway International Airport

    1. Take the bus from Ithaca, NY to Rochester, NYbus bus
    2. Fly from Rochester (ROC) to Chicago Midway International Airport (MDW)plane plane ROC - MDW
    6h 16m
    $112–611

  7. Bus to Buffalo Niagara International Airport, fly to Chicago O'Hare International Airport

    1. Take the bus from Ithaca, NY to Buffalo, NYbus bus
    2. Fly from Buffalo Niagara International Airport (BUF) to Chicago O'Hare International Airport (ORD)plane plane BUF - ORD
    7h 12m
    $97–530

  8. Bus to Buffalo Niagara International Airport, fly to Chicago Midway International Airport

    1. Take the bus from Ithaca, NY to Buffalo, NYbus bus
    2. Fly from Buffalo Niagara International Airport (BUF) to Chicago Midway International Airport (MDW)plane plane BUF - MDW
    7h 1m
    $122–770

  9. Bus to Wilkes-Barre/Scranton International Airport, fly to Chicago O'Hare International Airport

    1. Take the bus from Ithaca to Scrantonbus bus
    2. Fly from Wilkes-Barre/Scranton International Airport (AVP) to Chicago O'Hare International Airport (ORD)plane plane AVP - ORD
    7h 17m
    $117–523

Ithaca, NY to Chicago by foot, bus, and train

Calendar14Weekly Services
Duration14h 36mAverage Duration
Ticket$91Cheapest Price
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Questions & Answers

What companies run services between Ithaca, NY, USA and Chicago, IL, USA?

You can take a vehicle from Ithaca, NY to Chicago Bus Station via Ithaca, Buffalo, and Cleveland Bus Station in around 16h 53m.

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