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How to get fromItasca to St. Louisby train (Amtrak), bus (Flixbus), car, train, bus, plane or subway

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There are 7 ways to get from Itasca to St. Louis by train (Amtrak), bus (Flixbus), car, train, bus, plane, or subway

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train (Amtrak)

    best
    1. Take the train from Chicago Union Station to St. Louistrain train Lincoln Service / ...
    6h 35m
    $39–205

  2. Bus (Flixbus)

    1. Take the bus from Chicago Bus Station to St Louis Bus Stationbus bus FlixBus N2521 / ...
    8h 8m
    $39–75

  3. Drive 291.4 mi

    1. Drive from Itasca to St. Louiscar car 291.4 mi
    4h 53m
    $54–77

  4. Train, line 303 bus to Chicago O'Hare International Airport, fly to Lambert–St. Louis International Airport

    1. Take the train from Itasca to Franklin Parktrain train
    2. Take the bus from 25th Ave/Rose St & Belmont Ave/Pacific Ave to Rosemont CTA Stationbus bus
    3. Fly from Chicago O'Hare International Airport (ORD) to Lambert–St. Louis International Airport (STL)plane plane ORD - STL
    4h 23m
    $210–505

  5. Train, subway to Chicago Midway International Airport, fly to Lambert–St. Louis International Airport

    1. Take the train from Itasca to Chicago Union Stationtrain train
    2. Take the subway from LaSalle/Van Buren to Midwaysubway subway
    3. Fly from Chicago Midway International Airport (MDW) to Lambert–St. Louis International Airport (STL)plane plane MDW - STL
    4h 42m
    $94–613

  6. Fly Chicago O'Hare International Airport to Decatur Airport, drive

    1. Fly from Chicago O'Hare International Airport (ORD) to Decatur Airport (DEC)plane plane ORD - DEC
    2. Drive from Decatur Airport (DEC) to St. Louiscar car
    5h 56m
    $64–297

  7. Fly Chicago O'Hare International Airport to Abraham Lincoln Capital Airport, train

    1. Fly from Chicago O'Hare International Airport (ORD) to Abraham Lincoln Capital Airport (SPI)plane plane ORD - SPI
    2. Take the train from Springfield to St. Louistrain train
    6h 17m
    $74–403

Itasca to St. Louis by train (Amtrak)

Calendar38Weekly Trains
Duration6h 35mAverage Duration
Ticket$39Cheapest Price
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Questions & Answers

What companies run services between Itasca, IL, USA and St. Louis, MO, USA?

Amtrak operates a train from Chicago Union Station to St. Louis 5 times a day. Tickets cost $35–200 and the journey takes 4h 46m. Alternatively, Flixbus USA operates a bus from Chicago Bus Station to St Louis Bus Station 3 times a day. Tickets cost $35–70 and the journey takes 6h 10m.

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