There are 4 ways to get from Isola Ortigia to Palermo by bus, train or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Bus Interbus  •  3 h 15 min

  1. Take the bus from Via Paolo Orsi to P.za Cairoli interno, Stazione FS

$16 - $28

3 alternative options

Train  •  4 h 9 min

  1. Take the train from Siracusa to Palermo Centrale Rv

$25 - $55

Bus SAIS Autolinee  •  5 h 17 min

  1. Take the bus from Siracusa to Catania Airport
  2. Take the bus from Catania–Fontanarossa Airport to Palermo

$44 - $60

Drive  •  2 h 53 min

  1. Drive from Siracusa to Palermo 165 miles

$35 - $60

What companies run services between Isola Ortigia, Italy and Palermo, Italy?

Interbus operates a bus from Siracusa to Palermo twice daily. Tickets cost $16 - $28 and the journey takes 3 h 15 min. Alternatively, Trenitalia operates a train from Siracusa to Palermo once daily. Tickets cost $25 - $55 and the journey takes 4 h 9 min.

Train operators
Trenitalia
Phone
+39 06 68475475
Website
trenitalia.com
Train from Siracusa to Palermo Centrale
Ave. Duration
4 h 9 min
Frequency
Once daily
Estimated price
$25 - $55
Website
orario.trenitalia.com
1st Class
$45 - $55
Bus operators
Interbus
Website
interbus.it
Bus from Via Paolo Orsi to P.za Cairoli interno, Stazione FS
Ave. Duration
3 h 15 min
Frequency
Twice daily
Estimated price
$16 - $28
Schedules at
interbus.it
SAIS Autolinee

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Questions & Answers

The distance between Isola Ortigia and Palermo is 210 km. The road distance is 264 km.

The cheapest way to get from Isola Ortigia to Palermo is to bus which costs 13€ - 22€ and takes 3 h 15 min.

The quickest way to get from Isola Ortigia to Palermo is to drive which takes 2 h 53 min and costs 30€ - 50€.

Yes, there is a direct train departing from Siracusa and arriving at Palermo Centrale. Services depart once daily, and operate every day. The journey takes approximately 4 h 9 min.

Yes, there is a direct bus departing from Via Paolo Orsi and arriving at P.za Cairoli interno, Stazione FS. Services depart twice daily, and operate every day. The journey takes approximately 3 h 15 min.

The bus from Via Paolo Orsi to P.za Cairoli interno, Stazione FS takes 3 h 15 min including transfers and departs twice daily.