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How to get fromIsernia to MessinaBy train (Trenitalia), bus, car, ferry, train, or plane

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There are 9 ways to get from Isernia to Messina by train (Trenitalia), bus, car, ferry, train, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train (Trenitalia)

    best
    1. Take the train from Isernia to Casertatrain train Re
    2. Take the train from Caserta to Messina Centraletrain train Ic
    8h 51m
    €56–128
  2. Bus via Caserta

    cheapest
    1. Take the bus from Isernia to Caserta Terminal Busbus bus 433
    2. Take the bus from Caserta pzza Garibaldi to Messina Centrale Stationbus bus Autoservizi Salemi S201
    8h 55m
    €27–64
  3. Drive, ferry

    1. Drive from Isernia to Villa San Giovannicar car
    2. Take the ferry from Villa San Giovanni to Messina Marittimaferry ferry
    6h 13m
    €91–132
  4. Train to Naples Airport, fly to Catania–Fontanarossa Airport, train

    1. Take the train from Isernia to Casertatrain train
    2. Fly from Naples Airport (NAP) to Catania–Fontanarossa Airport (CTA)plane plane NAP - CTA
    3. Take the train from Catania Centrale to Messina Centraletrain train
    7h 51m
    €48–156
  5. Train, ferry

    1. Take the train from Isernia to Napoli Centraletrain train Re
    2. Take the train from Napoli Centrale to Villa S.Giovannitrain train Ic
    3. Take the ferry from Villa S.Giovanni to Messina Marittimaferry ferry V1 / ...
    10h 43m
  6. Bus

    1. Take the bus from Isernia to Salernobus bus 433
    2. Take the bus from Salerno to Messinabus bus N592 / ...
    11h
    €36–74
  7. Train to Fiumicino International Airport, fly to Catania–Fontanarossa Airport, train

    1. Take the train from Isernia to Roma Terminitrain train
    2. Fly from Fiumicino International Airport (FCO) to Catania–Fontanarossa Airport (CTA)plane plane FCO - CTA
    3. Take the train from Catania Centrale to Messina Centraletrain train
    8h 30m
    €66–199
  8. Bus to Abruzzo Airport, fly to Catania–Fontanarossa Airport, train

    1. Take the bus from Isernia to Pescarabus bus
    2. Fly from Abruzzo Airport (PSR) to Catania–Fontanarossa Airport (CTA)plane plane PSR - CTA
    3. Take the train from Catania Centrale to Messina Centraletrain train
    9h 20m
    €55–216
  9. Train to Naples Airport, fly to Palermo Airport, train

    1. Take the train from Isernia to Casertatrain train
    2. Fly from Naples Airport (NAP) to Palermo Airport (PMO)plane plane NAP - PMO
    3. Take the train from Palermo Centrale to Messina Centraletrain train
    9h 39m
    €62–180

Isernia to Messina by train (Trenitalia)

Calendar4Weekly Trains
Duration8h 51mAverage Duration
Ticket€56Cheapest Price
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Questions & Answers

What companies run services between Isernia, Italy and Messina, Italy?

You can take a train from Isernia to Messina Centrale via Caserta in around 8h 51m. Alternatively, you can take a bus from Isernia to Messina Centrale Station via Caserta Terminal Bus and Caserta pzza Garibaldi in around 8h 55m.

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