There are 9 ways to get from Isernia to Messina by train, ferry, bus, night train, car, or plane
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Train, ferry
best- Take the train from Isernia to Napoli Afragolatrain Re
- Take the train from Napoli Afragola to Villa S.Giovannitrain Fr
- Take the ferry from Villa S.Giovanni to Messina Marittimaferry V1 / ...
7h 16mBus via Caserta
cheapest- Take the bus from Isernia to Caserta Terminal Busbus 433
- Take the bus from Caserta pzza Garibaldi to Messina Centrale Stationbus Autoservizi Salemi S201
8h 55m€28–60Train, night train
- Take the train from Isernia to Casertatrain Re
- Take the nighttrain from Caserta to Messina Centralenighttrain Ini
8h 52m€46–85Drive, ferry
- Drive from Isernia to Villa San Giovannicar
- Take the ferry from Villa San Giovanni to Messina Marittimaferry
6h 13m€93–135Bus
- Take the bus from Isernia to Salernobus 433
- Take the bus from Salerno to Messinabus N592 / ...
11h€49–76Train to Naples Airport, fly to Catania–Fontanarossa Airport, train
- Take the train from Isernia to Casertatrain
- Fly from Naples Airport (NAP) to Catania–Fontanarossa Airport (CTA)plane NAP - CTA
- Take the train from Catania Centrale to Messina Centraletrain
7h 32m€49–200Train to Fiumicino International Airport, fly to Catania–Fontanarossa Airport, train
- Take the train from Isernia to Roma Terminitrain
- Fly from Fiumicino International Airport (FCO) to Catania–Fontanarossa Airport (CTA)plane FCO - CTA
- Take the train from Catania Centrale to Messina Centraletrain
8h 11m€58–167Train to Naples Airport, fly to Palermo Airport, train
- Take the train from Isernia to Casertatrain
- Fly from Naples Airport (NAP) to Palermo Airport (PMO)plane NAP - PMO
- Take the train from Palermo Centrale to Messina Centraletrain
9h 13m€63–231Bus, bus to Abruzzo Airport, fly to Catania–Fontanarossa Airport, train
- Take the bus from Isernia to San Salvo Marinabus
- Take the bus from San Salvo Marina to Pescara Airportbus
- Fly from Abruzzo Airport (PSR) to Catania–Fontanarossa Airport (CTA)plane PSR - CTA
- Take the train from Catania Centrale to Messina Centraletrain
8h 55m€52–212
Naples Airport (NAP) to Catania–Fontanarossa Airport (CTA) flights
Questions & Answers
The cheapest way to get from Isernia to Messina is to bus via Caserta which costs €27 - €60 and takes 8h 55m.
The fastest way to get from Isernia to Messina is to drive and ferry which takes 6h 13m and costs €90 - €140.
No, there is no direct bus from Isernia to Messina station. However, there are services departing from Isernia and arriving at Messina Centrale Station via Caserta pzza Garibaldi. The journey, including transfers, takes approximately 8h 55m.
No, there is no direct train from Isernia to Messina. However, there are services departing from Isernia and arriving at Messina Centrale via Caserta. The journey, including transfers, takes approximately 8h 52m.
The distance between Isernia and Messina is 547 km.
The best way to get from Isernia to Messina without a car is to train and ferry which takes 7h 16m and costs .
It takes approximately 7h 16m to get from Isernia to Messina, including transfers.
Isernia to Messina bus services, operated by FlixBus, depart from Isernia station.
Isernia to Messina train services, operated by Trenitalia, depart from Isernia station.
Isernia to Messina bus services, operated by FlixBus, arrive at Caserta Terminal Bus station.
What companies run services between Isernia, Italy and Messina, Italy?
You can take a bus from Isernia to Messina Centrale Station via Caserta Terminal Bus and Caserta pzza Garibaldi in around 8h 55m.
- Website
- ryanair.com
Flights from Naples Airport to Catania–Fontanarossa Airport
- Ave. Duration
- 1h 5m
- When
- Every day
- Estimated price
- €25–150
Flights from Fiumicino International Airport to Catania–Fontanarossa Airport
- Ave. Duration
- 1h 20m
- When
- Every day
- Estimated price
- €23–75
Flights from Fiumicino International Airport to Catania–Fontanarossa Airport via Malta
- Ave. Duration
- 3h 20m
- When
- Monday
- Estimated price
- €23–75
Flights from Naples Airport to Palermo Airport
- Ave. Duration
- 1h
- When
- Every day
- Estimated price
- €27–210
Flights from Abruzzo Airport to Catania–Fontanarossa Airport
- Ave. Duration
- 1h 20m
- When
- Saturday to Friday
- Estimated price
- €35–170
- Phone
- +39.06.5210550
- Website
- Trenitalia
Train from Isernia to Napoli Afragola
- Ave. Duration
- 1h 39m
- Frequency
- Every 4 hours
- Estimated price
- €14–20
- Website
- Trenitalia
Train from Isernia to Caserta
- Ave. Duration
- 1h 12m
- Frequency
- Every 3 hours
- Estimated price
- €10–15
- Website
- Trenitalia
Train from Isernia to Caserta
- Ave. Duration
- 1h 12m
- Frequency
- Every 3 hours
- Estimated price
- €10–15
- Website
- Trenitalia
Train from Catania Centrale to Messina Centrale
- Ave. Duration
- 2h 12m
- Frequency
- Every 30 minutes
- Estimated price
- €11–16
- Website
- Trenitalia
Train from Isernia to Roma Termini
- Ave. Duration
- 2h 24m
- Frequency
- Every 3 hours
- Estimated price
- €22–35
- Website
- Trenitalia
Train from Catania Centrale to Messina Centrale
- Ave. Duration
- 2h 12m
- Frequency
- Every 30 minutes
- Estimated price
- €11–16
- Website
- Trenitalia
Train from Isernia to Caserta
- Ave. Duration
- 1h 12m
- Frequency
- Every 3 hours
- Estimated price
- €10–15
- Website
- Trenitalia
Train from Palermo Centrale to Messina Centrale
- Ave. Duration
- 2h 54m
- Frequency
- Hourly
- Estimated price
- €26–40
- Website
- Trenitalia
Train from Catania Centrale to Messina Centrale
- Ave. Duration
- 2h 12m
- Frequency
- Every 30 minutes
- Estimated price
- €11–16
- Website
- Trenitalia
Rome2Rio's guide to FlixBus
Contact DetailsContact Details
- Phone
- +49 30 300 137 300
- service@flixbus.com
- Website
- Flixbus
Bus from Isernia to Caserta Terminal Bus
- Ave. Duration
- 1h 15m
- Frequency
- Once daily
- Estimated price
- €6–11
- Website
- Flixbus
Bus from Isernia to Salerno
- Ave. Duration
- 3h 35m
- Frequency
- Once daily
- Estimated price
- €14–21
- Website
- Flixbus
Bus from Salerno to Messina
- Ave. Duration
- 6h 25m
- Frequency
- Twice daily
- Estimated price
- €35–55
- Website
- Flixbus
- Phone
- +39.06.5210550
- Website
- Trenitalia
Ferry from Villa S.Giovanni to Messina Marittima
- Ave. Duration
- 20 min
- Frequency
- Hourly
- Website
- Trenitalia
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More Questions & Answers
Isernia to Messina train services, operated by Trenitalia, arrive at Caserta station.
Book your Isernia to Messina bus tickets online with Omio.
There are 1199+ hotels available in Messina.





