There are 5 ways to get from Isernia to Assisi by bus, train (Trenitalia), or car
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Bus via Rome
best- Take the bus from Isernia to Roma, Autostazione TiburtinaCampobasso / ...
- Take the bus from Roma, Autostazione Tiburtina to Assisi - Piazza San Pietro
5h 55m€32–69Train
cheapest- Take the train from Isernia to Roma TerminiRe
- Take the train from Roma Termini to Assisi4730 / ...
6h 42m€23–62Drive 286.1 km
- Drive from Isernia to Assisi286.1 km
4h 9m€45–65Train via Foligno
- Take the train from Isernia to Roma TerminiRe
- Take the train from Roma Termini to Foligno4150 / ...
6h 47m€23–83Bus
- Take the bus from Isernia to Chieti433
- Take the bus from Pescara to Assisi443
9h 47m€25–74
Isernia to Assisi by bus
Questions & Answers
The cheapest way to get from Isernia to Assisi is to bus via Rome which costs €30 - €70 and takes 5h 55m.
The fastest way to get from Isernia to Assisi is to drive which takes 4h 9m and costs €40 - €65.
No, there is no direct bus from Isernia to Assisi. However, there are services departing from Isernia and arriving at Assisi - Piazza San Pietro via Roma, Autostazione Tiburtina. The journey, including transfers, takes approximately 5h 55m.
The distance between Isernia and Assisi is 368 km. The road distance is 286.1 km.
The best way to get from Isernia to Assisi without a car is to bus via Rome which takes 5h 55m and costs €30 - €70.
It takes approximately 5h 55m to get from Isernia to Assisi, including transfers.
Isernia to Assisi bus services, operated by ATM Azienda di Trasporti Molisana S.p.A., depart from Isernia station.
The best way to get from Isernia to Assisi is to bus via Rome which takes 5h 55m and costs €30 - €70. Alternatively, you can train, which costs €23 - €65 and takes 6h 42m.
Isernia to Assisi bus services, operated by ATM Azienda di Trasporti Molisana S.p.A., arrive at Roma, Autostazione Tiburtina station.
Yes, the driving distance between Isernia to Assisi is 286 km. It takes approximately 4h 9m to drive from Isernia to Assisi.
What companies run services between Isernia, Italy and Assisi, Italy?
You can take a bus from Isernia to Assisi - Piazza San Pietro via Roma, Autostazione Tiburtina in around 5h 55m. Alternatively, you can take a train from Isernia to Piazza Matteotti Assisi via Roma Termini, Assisi, and Assisi Station in around 6h 42m.
Transport is disrupted due to the Russia-Ukraine war. Read more
- Phone
- +39.06.5210550
- Website
- trenitalia.com
Train from Isernia to Roma Termini
- Ave. Duration
- 2h 22m
- Frequency
- Every 4 hours
- Estimated price
- €11–35
- Website
- https://www.trenitalia.com/en.html
- 1st Class
- €24–35
Train from Roma Termini to Assisi
- Ave. Duration
- 2h 8m
- Frequency
- 4 times a day
- Estimated price
- €21–22
- Website
- https://www.trenitalia.com/en.html
Train from Roma Termini to Foligno
- Ave. Duration
- 1h 52m
- Frequency
- Every 2 hours
- Estimated price
- €14–25
- Website
- https://www.trenitalia.com/en.html
- Phone
- +39 06 68475475
- Website
- trenitalia.com
Train from Roma Termini to Assisi
- Ave. Duration
- 2h 5m
- Frequency
- 6 times a week
- Estimated price
- €11–25
- Website
- https://www.trenitalia.com/en.html
Train from Roma Termini to Foligno
- Ave. Duration
- 1h 54m
- Frequency
- 3 times a day
- Estimated price
- €9–23
- Website
- https://www.trenitalia.com/en.html
- Phone
- +39 06 68475475
- Website
- trenitalia.com
Train from Roma Termini to Foligno
- Ave. Duration
- 1h 42m
- Frequency
- Once daily
- Estimated price
- €23–35
- Schedules at
- trenitalia.com
- Phone
- +39 0874 64744
- info@atm-molise.it
- Website
- atm-molise.it
Bus from Isernia to Roma, Autostazione Tiburtina
- Ave. Duration
- 2h 10m
- Frequency
- 3 times a day
- Estimated price
- €8–13
- Schedules at
- atm-molise.it
Rome2Rio's guide to FlixBus
Contact Details
- Phone
- +49 30 300 137 300
- service@flixbus.com
- Website
- flixbus.fr
Bus from Isernia to Roma, Autostazione Tiburtina
- Ave. Duration
- 2h 10m
- Frequency
- Once daily
- Estimated price
- €16–45
- Website
- https://www.flixbus.co.uk
Bus from Isernia to Chieti
- Ave. Duration
- 2h 34m
- Frequency
- Once daily
- Estimated price
- €10–27
- Website
- https://www.flixbus.co.uk
Bus from Pescara to Assisi
- Ave. Duration
- 4h
- Frequency
- Twice daily
- Estimated price
- €12–40
- Website
- https://www.flixbus.co.uk
- Phone
- +39 075 5009641
- info@sulga.it
- Website
- sulga.it
Bus from Roma, Autostazione Tiburtina to Assisi - Piazza San Pietro
- Ave. Duration
- 2h 45m
- Frequency
- 6 times a week
- Estimated price
- €23–26
- Schedules at
- sulga.it
- 2nd Class
- €23–26
Want to know more about travelling around Italy
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Italy Travel Guides
Read the travel guide
Want to know more about Flixbus?
Read the travel guide
More Questions & Answers
Book your Isernia to Assisi bus tickets online with Omio.
There are 2210+ hotels available in Assisi.

























