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How to get fromIrvine to Indianaby plane, train, bus (Greyhound), train (Amtrak), or car

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There are 7 ways to get from Irvine to Indiana by plane, train, bus (Greyhound), train (Amtrak), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly John Wayne Airport Orange County to Chicago O'Hare International Airport, train

    best
    1. Fly from John Wayne Airport Orange County (SNA) to Chicago O'Hare International Airport (ORD)plane plane SNA - ORD
    2. Take the train from Van Buren St. to Gary Metro Centertrain train
    6h 18m
    $200–430

  2. Train to Los Angeles International Airport, fly to Chicago O'Hare International Airport, train

    cheapest
    1. Take the train from Tustin to L.A. Union Stationtrain train
    2. Fly from Los Angeles International Airport (LAX) to Chicago O'Hare International Airport (ORD)plane plane LAX - ORD
    3. Take the train from Van Buren St. to Gary Metro Centertrain train
    9h 2m
    $145–399

  3. Bus (Greyhound)

    1. Take the bus from Anaheim Regional Transportation Intermodal Center to Montclair Transcenterbus bus
    2. Take the bus from Montclair Transcenter to St Louis Bus Stationbus bus
    3. Take the bus from St Louis Bus Station to Indianapolis Union Stationbus bus
    2d 1h
    $336–640

  4. Train (Amtrak)

    1. Take the train from Fullerton Amtrak Station to Chicago Union Stationtrain train Southwest Chief
    2. Take the train from Chicago Union Station to Indianapolistrain train Cardinal
    2d 2h
    $607–1,429

  5. Drive  2,049 mi

    1. Drive from Irvine to Indianapoliscar car 2,049 mi
    32h 48m
    $374–541

  6. Train to Los Angeles International Airport, fly to Indianapolis

    1. Take the train from Tustin to L.A. Union Stationtrain train
    2. Fly from Los Angeles International Airport (LAX) to Indianapolis (IND)plane plane LAX - IND
    7h 57m
    $178–397

  7. Train to Los Angeles International Airport, fly to Chicago Midway International Airport, train

    1. Take the train from Tustin to L.A. Union Stationtrain train
    2. Fly from Los Angeles International Airport (LAX) to Chicago Midway International Airport (MDW)plane plane LAX - MDW
    3. Take the train from Van Buren St. to Gary Metro Centertrain train
    8h 41m
    $165–639

Irvine to Indiana by bus (Greyhound)

Calendar7Weekly Buses
Duration2d 1hAverage Duration
Ticket$336Cheapest Price
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Questions & Answers

Map of how to get from Irvine to Indiana.ExpandLaunch map view
  • Distance: 1,769.7 mi
  • Duration: 6h 18m

What companies run services between Irvine, CA, USA and Indiana, USA?

You can take a bus from Main-Harvard to Indianapolis Union Station via Artic - Dock 4, Anaheim Regional Transportation Intermodal Center, Montclair Transcenter, and St Louis Bus Station in around 2d 1h. Alternatively, you can take a train from Tustin to Indianapolis via Fullerton, Fullerton Amtrak Station, and Chicago Union Station in around 2d 2h.

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