There are 6 ways to get from Irvine to Durham by plane, bus (Greyhound, Flixbus), train (Amtrak), car, or train
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly John Wayne Airport Orange County to Raleigh-Durham International Airport
best- Fly from John Wayne Airport Orange County (SNA) to Raleigh-Durham International Airport (RDU)SNA - RDU
6h 42m$178–754Bus
- Take the bus from Anaheim to Los Angeles Union Station
- Take the bus from Los Angeles Union Station to Dallas Bus Station
- Take the bus from Dallas Bus Station to Atlanta Bus Station
- Take the bus from Atlanta Bus Station to Durham
2d 12h$245–612Train (Amtrak)
- Take the train from Fullerton Amtrak Station to Chicago Union Station
- Take the train from Chicago Union Station to Cary
2d 22h$362–3,516Drive 2,482.8 mi
- Drive from Irvine to Durham2,482.8 mi
40h 29m$454–655Train to Los Angeles International Airport, fly to Raleigh-Durham International Airport
- Take the train from Tustin to L.A. Union Station
- Fly from Los Angeles International Airport (LAX) to Raleigh-Durham International Airport (RDU)LAX - RDU
8h 53m$189–578Fly John Wayne Airport Orange County to Charlotte Douglas International Airport, train
- Fly from John Wayne Airport Orange County (SNA) to Charlotte Douglas International Airport (CLT)SNA - CLT
- Take the train from Charlotte Amtrak Station to Durham Amtrak Station
9h 30m$311–741
Irvine to Durham by bus
Questions & Answers
The cheapest way to get from Irvine to Durham is to train and fly which costs $180 - $600 and takes 8h 53m.
The fastest way to get from Irvine to Durham is to fly which takes 6h 42m and costs $170 - $800.
No, there is no direct bus from Irvine to Durham. However, there are services departing from Main-Harvard and arriving at Durham via Anaheim, Los Angeles Union Station, Dallas Bus Station and Atlanta Bus Station. The journey, including transfers, takes approximately 2 days 12h.
No, there is no direct train from Irvine to Durham station. However, there are services departing from Tustin and arriving at Durham Amtrak Station via Fullerton Amtrak Station, Chicago Union Station and Cary. The journey, including transfers, takes approximately 2 days 22h.
The distance between Irvine and Durham is 2236 miles. The road distance is 2497.3 miles.
The best way to get from Irvine to Durham without a car is to bus which takes 2 days 12h and costs $240 - $650.
It takes approximately 6h 42m to get from Irvine to Durham, including transfers.
Irvine to Durham bus services, operated by Greyhound Mexico, depart from Anaheim station.
Irvine to Durham train services, operated by Amtrak, depart from Fullerton Amtrak Station.
The best way to get from Irvine to Durham is to fly which takes 6h 42m and costs $170 - $800. Alternatively, you can bus, which costs $240 - $650 and takes 2 days 12h, you could also train, which costs $360 - $3,600 and takes 2 days 22h.
What companies run services between Irvine, CA, USA and Durham, NC, USA?
Breeze Airways, Delta, and two other airlines fly from John Wayne Airport Orange County (SNA) to Raleigh-Durham International Airport (RDU) 4 times a day. Alternatively, you can take a bus from Main-Harvard to Durham via Artic - Dock 4, Anaheim, Los Angeles Union Station, Dallas Bus Station, and Atlanta Bus Station in around 2d 12h.
- Website
- aa.com
Flights from John Wayne Airport Orange County to Raleigh-Durham International Airport via Charlotte Douglas International Airport
- Ave. Duration
- 8h 13m
- When
- Every day
- Estimated price
- $170–800
Flights from Los Angeles International Airport to Raleigh-Durham International Airport
- Ave. Duration
- 4h 50m
- When
- Every day
- Estimated price
- $140–600
Flights from Los Angeles International Airport to Raleigh-Durham International Airport via Charlotte Douglas International Airport
- Ave. Duration
- 6h 55m
- When
- Every day
- Estimated price
- $140–600
Flights from Los Angeles International Airport to Raleigh-Durham International Airport via Nashville
- Ave. Duration
- 6h 37m
- When
- Monday, Friday, Saturday, and Sunday
- Estimated price
- $140–600
Flights from John Wayne Airport Orange County to Charlotte Douglas International Airport
- Ave. Duration
- 4h 43m
- When
- Every day
- Estimated price
- $150–650
Flights from John Wayne Airport Orange County to Charlotte Douglas International Airport via Dallas/Ft.Worth
- Ave. Duration
- 6h 54m
- When
- Every day
- Estimated price
- $150–700
- Website
- southwest.com
Flights from John Wayne Airport Orange County to Raleigh-Durham International Airport via Dallas
- Ave. Duration
- 7h
- When
- Monday, Tuesday, Friday, Saturday, and Sunday
- Estimated price
- $180–800
Flights from John Wayne Airport Orange County to Raleigh-Durham International Airport via Nashville
- Ave. Duration
- 8h 20m
- When
- Saturday
- Estimated price
- $170–750
Flights from John Wayne Airport Orange County to Raleigh-Durham International Airport via Austin
- Ave. Duration
- 8h 55m
- When
- Monday, Tuesday, Friday, and Sunday
- Estimated price
- $180–800
Flights from Los Angeles International Airport to Raleigh-Durham International Airport via Nashville
- Ave. Duration
- 8h 21m
- When
- Every day
- Estimated price
- $140–600
Flights from John Wayne Airport Orange County to Charlotte Douglas International Airport via Nashville
- Ave. Duration
- 7h 22m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $150–650
Flights from John Wayne Airport Orange County to Charlotte Douglas International Airport via Dallas
- Ave. Duration
- 9h 5m
- When
- Monday, Tuesday, Friday, and Sunday
- Estimated price
- $150–700
- Website
- delta.com
Flights from John Wayne Airport Orange County to Raleigh-Durham International Airport via Atlanta
- Ave. Duration
- 7h 8m
- When
- Monday, Tuesday, Friday, Saturday, and Sunday
- Estimated price
- $180–800
Flights from Los Angeles International Airport to Raleigh-Durham International Airport
- Ave. Duration
- 4h 41m
- When
- Every day
- Estimated price
- $140–600
Flights from John Wayne Airport Orange County to Charlotte Douglas International Airport via Atlanta
- Ave. Duration
- 7h 21m
- When
- Monday, Tuesday, Friday, Saturday, and Sunday
- Estimated price
- $150–700
- Website
- flybreeze.com
Flights from John Wayne Airport Orange County to Raleigh-Durham International Airport
- Ave. Duration
- 5h 5m
- When
- Monday and Friday
- Estimated price
- $320–1,100
Rome2Rio's guide to Amtrak
Contact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Train from Fullerton Amtrak Station to Chicago Union Station
- Ave. Duration
- 42h 47m
- Frequency
- Once daily
- Estimated price
- $170–1,700
- Website
- https://www.amtrak.com/home.html
Train from Chicago Union Station to Cary
- Ave. Duration
- 24h 21m
- Frequency
- Once daily
- Estimated price
- $180–1,800
- Website
- https://www.amtrak.com/home.html
Train from Charlotte Amtrak Station to Durham Amtrak Station
- Ave. Duration
- 2h 35m
- Frequency
- 5 times a day
- Estimated price
- $28–33
- Website
- https://www.amtrak.com/home.html
- Phone
- (800) 371-LINK (5465)
- Website
- metrolinktrains.com
Train from Tustin to L.A. Union Station
- Ave. Duration
- 1h
- Frequency
- Every 3 hours
- Estimated price
- $8–11
- Website
- https://metrolinktrains.com
- Passenger
- $8–11
- Phone
- +1-800-231-2222
- ifsr@greyhound.com
- Website
- greyhound.com.mx
Bus from Anaheim to Los Angeles Union Station
- Ave. Duration
- 45 min
- Frequency
- Twice daily
- Estimated price
- $8–40
- Schedules at
- greyhound.com.mx
Rome2Rio's guide to Greyhound USA
Contact Details
- Phone
- +1 214-849-8100
- ifsr@greyhound.com
- Website
- greyhound.com
Bus from Los Angeles Union Station to Dallas Bus Station
- Ave. Duration
- 29h 15m
- Frequency
- Twice daily
- Estimated price
- $110–260
- Website
- https://www.greyhound.com/
Bus from Dallas Bus Station to Atlanta Bus Station
- Ave. Duration
- 18h 5m
- Frequency
- 3 times a day
- Estimated price
- $75–170
- Website
- https://www.greyhound.com/
Bus from Atlanta Bus Station to Durham
- Ave. Duration
- 8h 20m
- Frequency
- Once daily
- Estimated price
- $50–140
- Website
- https://www.greyhound.com/
- Phone
- +1 (855) 626-8585
- Website
- flixbus.com
Bus from Atlanta Bus Station to Durham
- Ave. Duration
- 7h 20m
- Frequency
- 3 times a day
- Estimated price
- $50–85
- Schedules at
- flixbus.com
Want to know more about travelling around United States
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More Questions & Answers
Irvine to Durham bus services, operated by Greyhound Mexico, arrive at Los Angeles Union Station.
Durham is 3h ahead of Irvine. It is currently 3:51 PM in Irvine and 6:51 PM in Durham.
Irvine to Durham train services, operated by Amtrak, arrive at Chicago Union Station.
Yes, the driving distance between Irvine to Durham is 2497 miles. It takes approximately 40h 29m to drive from Irvine to Durham.
There are 336+ hotels available in Durham.

















