Rome2Rio

How to get fromIrvine to Buffaloby plane, train (Amtrak), bus (Greyhound), car or train

Find Transport to Buffalo

See all options

There are 5 ways to get from Irvine to Buffalo by plane, train (Amtrak), bus (Greyhound), car, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from John Wayne Airport Orange County

    best
    1. Fly from John Wayne Airport Orange County (SNA) to Buffalo Niagara International Airport (BUF)planeSNA - BUF
    7h 53m
    $458–1,992

  2. Bus

    cheapest
    1. Take the bus from Santa Ana Bus Stop to Las Vegas BusTerminalbus
    2. Take the bus from Las Vegas BusTerminal to Denver Union Stationbus
    3. Take the bus from Denver Union Station to Chicago Bus Stationbus
    4. Take the bus from Chicago Bus Station to Cleveland Bus Stationbus
    5. Take the bus from Cleveland, OH to Buffalo, NYbus
    2d 10h
    $245–657

  3. Train (Amtrak)

    1. Take the train from Fullerton Amtrak Station to Chicago Union StationtrainSouthwest Chief
    2. Take the train from Chicago Union Station to Buffalo Depew StationtrainLake Shore Limited
    2d 8h
    $259–1,992

  4. Drive 2,529.4 mi

    1. Drive from Irvine to Buffalocar2,529.4 mi
    40h 2m
    $462–667

  5. Train to Los Angeles International Airport, fly

    1. Take the train from Tustin to L.A. Union Stationtrain
    2. Fly from Los Angeles International Airport (LAX) to Buffalo Niagara International Airport (BUF)planeLAX - BUF
    8h 27m
    $373–1,605

Irvine to Buffalo by train (Amtrak)

Calendar7Weekly Trains
Duration2d 8hAverage Duration
Ticket$259Cheapest Price
See schedules

Questions & Answers

What companies run services between Irvine, CA, USA and Buffalo, NY, USA?

United Airlines, American Airlines, and two other airlines fly from John Wayne Airport Orange County (SNA) to Buffalo Niagara International Airport (BUF) every 4 hours. Alternatively, you can take a train from Tustin to Buffalo via Fullerton, Fullerton Amtrak Station, Chicago Union Station, and Buffalo Depew Station in around 2d 8h.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

More Questions & Answers

Where to next?

Trips from Irvine

Trips to Buffalo

Popular routes