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How to get fromIowa to Tupeloby plane, bus (Greyhound, Flixbus), car, bus, bus (Greyhound, Amtrak, Flixbus), or train

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There are 8 ways to get from Iowa to Tupelo by plane, bus (Greyhound, Flixbus), car, bus, bus (Greyhound, Amtrak, Flixbus), or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Des Moines

    best
    1. Fly from Des Moines (DSM) to Tupelo Regional Airport (TUP)plane plane DSM - TUP
    6h 59m
    $132–639

  2. Fly from Quad City International Airport

    cheapest
    1. Fly from Quad City International Airport (MLI) to Tupelo Regional Airport (TUP)plane plane MLI - TUP
    8h 58m
    $101–480

  3. Bus via Kansas City

    1. Take the bus from Des Moines to Kansas Citybus bus
    2. Take the bus from Kansas City Bus Station to St Louis Bus Stationbus bus
    3. Take the bus from St Louis Bus Station to Memphis Bus Stationbus bus
    4. Take the bus from Memphis Bus Station to Tupelobus bus
    17h 49m
    $154–275

  4. Drive  681.7 mi

    1. Drive from Des Moines to Tupelocar car 681.7 mi
    12h 45m
    $125–180

  5. Fly from Omaha

    1. Fly from Omaha (OMA) to Tupelo Regional Airport (TUP)plane plane OMA - TUP
    7h 23m
    $127–621

  6. Bus to The Eastern Iowa Airport, fly

    1. Take the bus from Court St Transportation Center to GTC Bay 9bus bus
    2. Fly from The Eastern Iowa Airport (CID) to Tupelo Regional Airport (TUP)plane plane CID - TUP
    7h 20m

  7. Bus

    1. Take the bus from Des Moines to Galesburgbus bus
    2. Take the bus from Galesburg Amtrak Station to Springfieldbus bus
    3. Take the bus from Springfield SMTD Transfer Center to Memphis Bus Stationbus bus
    4. Take the bus from Memphis Bus Station to Tupelobus bus
    18h 51m
    $152–260

  8. Bus, train

    1. Take the bus from Des Moines to Kansas Citybus bus
    2. Take the train from Kansas City to St. Louistrain train
    3. Take the bus from St Louis Bus Station to Memphis Bus Stationbus bus
    4. Take the bus from Memphis Bus Station to Tupelobus bus
    20h 9m
    $189–370

Des Moines (DSM) to Tupelo Regional Airport (TUP) flights

Calendar15Weekly Planes
Duration8h 26mAverage Duration
Ticket$105Cheapest Price
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Questions & Answers

Map of how to get from Iowa to Tupelo.ExpandLaunch map view
  • Distance: 578.9 mi
  • Duration: 6h 59m

What companies run services between Iowa, USA and Tupelo, MS, USA?

American Airlines, Corporate Flight Management Inc, and four other airlines fly from Des Moines (DSM) to Tupelo Regional Airport (TUP) twice daily. Alternatively, you can take a bus from Des Moines to Tupelo via Kansas City, Kansas City Bus Station, St Louis Bus Station, Memphis Bus Station, and Tupelo in around 17h 49m.

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