There are 8 ways to get from Iowa to Tupelo by bus (Greyhound, Flixbus), car, plane, bus (Greyhound), bus, or train
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Bus via St. Louis
best- Take the bus from Des Moines to St Louis Bus Stationbus
- Take the bus from St Louis Bus Station to Memphis Bus Stationbus
- Take the bus from Memphis Bus Station to Tupelobus
16h 50m$136–294Fly Quad City International Airport to Golden Triangle Regional Airport, drive
cheapest- Fly from Quad City International Airport (MLI) to Golden Triangle Regional Airport (GTR)plane MLI - GTR
- Drive from Golden Triangle Regional Airport (GTR) to Tupelocar
10h 7m$93–449Drive 681.7 mi
- Drive from Des Moines to Tupelocar 681.7 mi
12h 45m$125–180Bus
- Take the bus from Des Moines to Kansas Citybus
- Take the bus from Kansas City to Memphis Bus Stationbus
- Take the bus from Memphis Bus Station to Tupelobus
17h 20m$196–294Bus, train
- Take the bus from Des Moines to Kansas Citybus
- Take the train from Kansas City to St. Louistrain
- Take the bus from St Louis Bus Station to Memphis Bus Stationbus
- Take the bus from Memphis Bus Station to Tupelobus
19h 23m$196–399Fly Des Moines to Tupelo Regional Airport
- Fly from Des Moines (DSM) to Tupelo Regional Airport (TUP)plane DSM - TUP
7h 1m$162–739Fly Omaha to Tupelo Regional Airport
- Fly from Omaha (OMA) to Tupelo Regional Airport (TUP)plane OMA - TUP
7h 38m$147–771Fly Quad City International Airport to Tupelo Regional Airport
- Fly from Quad City International Airport (MLI) to Tupelo Regional Airport (TUP)plane MLI - TUP
8h 46m$101–490
Quad City International Airport (MLI) to Golden Triangle Regional Airport (GTR) flights
Questions & Answers
The cheapest way to get from Iowa to Tupelo is to drive which costs $120 - $180 and takes 12h 45m.
The fastest way to get from Iowa to Tupelo is to fly which takes 7h 1m and costs $160 - $750.
The distance between Iowa and Tupelo is 816 miles. The road distance is 685.7 miles.
The best way to get from Iowa to Tupelo without a car is to bus via St. Louis which takes 16h 50m and costs $130 - $300.
It takes approximately 16h 50m to get from Iowa to Tupelo, including transfers.
The best way to get from Iowa to Tupelo is to bus via St. Louis which takes 16h 50m and costs $130 - $300. Alternatively, you can fly, which costs $160 - $750 and takes 7h 1m.
Yes, the driving distance between Iowa to Tupelo is 686 miles. It takes approximately 12h 45m to drive from Iowa to Tupelo.
There are 32+ hotels available in Tupelo.
What companies run services between Iowa, USA and Tupelo, MS, USA?
You can take a vehicle from Des Moines to Tupelo via Des Moines, St Louis Bus Station, Memphis Bus Station, and Tupelo in around 16h 50m. Alternatively, American Airlines, Corporate Flight Management Inc, and two other airlines fly from Des Moines (DSM) to Tupelo Regional Airport (TUP) 3 times a day.
- Website
- contouraviation.com
Flights from Des Moines to Tupelo Regional Airport via Dallas/Ft.Worth
- Ave. Duration
- 8h 3m
- When
- Every day
- Estimated price
- $150–750
Flights from Des Moines to Tupelo Regional Airport via Chicago O'Hare, Nashville
- Ave. Duration
- 6h 45m
- When
- Sunday
- Estimated price
- $130–700
Flights from Des Moines to Tupelo Regional Airport via Atlanta, Nashville
- Ave. Duration
- 6h 53m
- When
- Every day
- Estimated price
- $150–750
Flights from Des Moines to Tupelo Regional Airport via Chicago Midway, Nashville
- Ave. Duration
- 7h
- When
- Monday to Saturday
- Estimated price
- $130–700
Flights from Des Moines to Tupelo Regional Airport via Minneapolis, Nashville
- Ave. Duration
- 11h 45m
- When
- Sunday
- Estimated price
- $150–750
Flights from Omaha to Tupelo Regional Airport via Dallas/Ft.Worth
- Ave. Duration
- 5h 17m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $170–850
Flights from Omaha to Tupelo Regional Airport via Nashville
- Ave. Duration
- 5h 15m
- When
- Monday, Thursday, Friday, and Saturday
- Estimated price
- $130–750
Flights from Omaha to Tupelo Regional Airport via Atlanta, Nashville
- Ave. Duration
- 7h 18m
- When
- Every day
- Estimated price
- $180–900
Flights from Omaha to Tupelo Regional Airport via Chicago Midway, Nashville
- Ave. Duration
- 7h 32m
- When
- Every day
- Estimated price
- $160–800
Flights from Omaha to Tupelo Regional Airport via Chicago O'Hare, Nashville
- Ave. Duration
- 7h 14m
- When
- Sunday
- Estimated price
- $160–800
Flights from Omaha to Tupelo Regional Airport via Minneapolis, Nashville
- Ave. Duration
- 9h 35m
- When
- Sunday
- Estimated price
- $180–850
Flights from Quad City International Airport to Tupelo Regional Airport via Dallas/Ft.Worth
- Ave. Duration
- 6h 50m
- When
- Every day
- Estimated price
- $120–600
Flights from Quad City International Airport to Tupelo Regional Airport via Atlanta, Nashville
- Ave. Duration
- 6h 25m
- When
- Monday to Saturday
- Estimated price
- $110–550
Flights from Quad City International Airport to Tupelo Regional Airport via Chicago O'Hare, Nashville
- Ave. Duration
- 7h 35m
- When
- Every day
- Estimated price
- $85–470
Flights from Quad City International Airport to Tupelo Regional Airport via Charlotte, Nashville
- Ave. Duration
- 11h 45m
- When
- Sunday
- Estimated price
- $120–600
- Website
- delta.com
Flights from Quad City International Airport to Golden Triangle Regional Airport via Atlanta
- Ave. Duration
- 7h 24m
- When
- Every day
- Estimated price
- $80–430
Flights from Quad City International Airport to Golden Triangle Regional Airport via Chicago O'Hare, Atlanta
- Ave. Duration
- 6h 44m
- When
- Every day
- Estimated price
- $90–450
- Website
- aa.com
Flights from Quad City International Airport to Golden Triangle Regional Airport via Dallas/Ft.Worth
- Ave. Duration
- 8h 2m
- When
- Every day
- Estimated price
- $100–490
Rome2Rio's guide to Amtrak
Contact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Train from Kansas City to St. Louis
- Ave. Duration
- 5h 40m
- Frequency
- Twice daily
- Estimated price
- $75–170
- Website
- https://www.amtrak.com/home.html
Rome2Rio's guide to Greyhound USA
Contact Details
- Phone
- +1 214-849-8100
- ifsr@greyhound.com
- Website
- greyhound.com
Bus from Des Moines to St Louis Bus Station
- Ave. Duration
- 8h 15m
- Frequency
- Once daily
- Estimated price
- $65–140
- Website
- https://www.greyhound.com/
Bus from St Louis Bus Station to Memphis Bus Station
- Ave. Duration
- 5h 30m
- Frequency
- Once daily
- Estimated price
- $45–95
- Website
- https://www.greyhound.com/
Bus from Memphis Bus Station to Tupelo
- Ave. Duration
- 1h 40m
- Frequency
- Twice daily
- Estimated price
- $16–35
- Website
- https://www.greyhound.com/
- Phone
- +1 (855) 626-8585
- Website
- flixbus.com
Bus from St Louis Bus Station to Memphis Bus Station
- Ave. Duration
- 4h 45m
- Frequency
- Once daily
- Estimated price
- $35–65
- Schedules at
- flixbus.com
- Phone
- +1-858-800-8898
- Website
- jeffersonlines.com
Bus from Des Moines to Kansas City
- Ave. Duration
- 3h 30m
- Frequency
- Twice daily
- Estimated price
- $50–75
- Book at
- https://www.jeffersonlines.com
- Adult
- $50–75
Bus from Kansas City to Memphis Bus Station
- Ave. Duration
- 10h
- Frequency
- 4 times a week
- Estimated price
- $110–160
- Book at
- https://www.jeffersonlines.com
- Adult
- $110–160
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