There are 6 ways to get from Iowa to Tupelo by plane, bus (Greyhound, Flixbus), car, bus (Greyhound), bus, or train
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly from Des Moines
best- Fly from Des Moines (DSM) to Tupelo Regional Airport (TUP)plane DSM - TUP
5h 12m$142–639Fly from Omaha
cheapest- Fly from Omaha (OMA) to Tupelo Regional Airport (TUP)plane OMA - TUP
7h 23m$112–501Bus via St. Louis
- Take the bus from Des Moines to St Louis Bus Stationbus
- Take the bus from St Louis Bus Station to Memphis Bus Stationbus
- Take the bus from Memphis Bus Station to Tupelobus
17h$135–258Drive 681.7 mi
- Drive from Des Moines to Tupelocar 681.7 mi
12h 45m$125–180Bus
- Take the bus from Des Moines to Kansas Citybus
- Take the bus from Kansas City to Memphis Bus Stationbus
- Take the bus from Memphis Bus Station to Tupelobus
17h 19m$189–275Bus, train
- Take the bus from Des Moines to Kansas Citybus
- Take the train from Kansas City to St. Louistrain
- Take the bus from St Louis Bus Station to Memphis Bus Stationbus
- Take the bus from Memphis Bus Station to Tupelobus
19h 24m$209–390
Des Moines (DSM) to Tupelo Regional Airport (TUP) flights
Questions & Answers
The cheapest way to get from Iowa to Tupelo is to drive which costs $120 - $180 and takes 12h 45m.
The fastest way to get from Iowa to Tupelo is to fly which takes 5h 12m and costs $140 - $650.
No, there is no direct bus from Iowa to Tupelo. However, there are services departing from Des Moines and arriving at Tupelo via St Louis Bus Station and Memphis Bus Station. The journey, including transfers, takes approximately 17h.
The distance between Iowa and Tupelo is 582 miles. The road distance is 685.7 miles.
The best way to get from Iowa to Tupelo without a car is to bus via St. Louis which takes 17h and costs $130 - $260.
It takes approximately 5h 12m to get from Iowa to Tupelo, including transfers.
Iowa to Tupelo bus services, operated by Greyhound USA, depart from Des Moines station.
The best way to get from Iowa to Tupelo is to fly which takes 5h 12m and costs $140 - $650. Alternatively, you can bus via St. Louis, which costs $130 - $260 and takes 17h.
Iowa to Tupelo bus services, operated by Greyhound USA, arrive at St Louis Bus Station.
Yes, the driving distance between Iowa to Tupelo is 686 miles. It takes approximately 12h 45m to drive from Iowa to Tupelo.
What companies run services between Iowa, USA and Tupelo, MS, USA?
American Airlines, Corporate Flight Management Inc, and four other airlines fly from Des Moines (DSM) to Tupelo Regional Airport (TUP) twice daily. Alternatively, you can take a vehicle from Des Moines to Tupelo via Des Moines, St Louis Bus Station, Memphis Bus Station, and Tupelo in around 17h.
- Website
- contouraviation.com
Flights from Des Moines to Tupelo Regional Airport via Dallas/Ft.Worth
- Ave. Duration
- 4h 53m
- When
- Sunday
- Estimated price
- $150–700
Flights from Des Moines to Tupelo Regional Airport via Nashville
- Ave. Duration
- 9h 17m
- When
- Sunday
- Estimated price
- $110–600
Flights from Des Moines to Tupelo Regional Airport via Chicago Midway, Nashville
- Ave. Duration
- 6h 40m
- When
- Monday, Thursday, and Friday
- Estimated price
- $120–650
Flights from Des Moines to Tupelo Regional Airport via Atlanta, Nashville
- Ave. Duration
- 6h 58m
- When
- Every day
- Estimated price
- $150–700
Flights from Des Moines to Tupelo Regional Airport via Chicago O'Hare, Nashville
- Ave. Duration
- 7h 13m
- When
- Sunday
- Estimated price
- $130–650
Flights from Des Moines to Tupelo Regional Airport via Detroit, Nashville
- Ave. Duration
- 8h 22m
- When
- Sunday
- Estimated price
- $150–750
Flights from Omaha to Tupelo Regional Airport via Nashville
- Ave. Duration
- 4h 30m
- When
- Sunday
- Estimated price
- $95–480
Flights from Omaha to Tupelo Regional Airport via Dallas/Ft.Worth
- Ave. Duration
- 7h 25m
- When
- Every day
- Estimated price
- $110–550
Flights from Omaha to Tupelo Regional Airport via Chicago Midway, Nashville
- Ave. Duration
- 7h 10m
- When
- Monday, Thursday, Friday, and Sunday
- Estimated price
- $110–550
Flights from Omaha to Tupelo Regional Airport via Atlanta, Nashville
- Ave. Duration
- 7h 27m
- When
- Every day
- Estimated price
- $130–600
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Train from Kansas City to St. Louis
- Ave. Duration
- 5h 40m
- Frequency
- Twice daily
- Estimated price
- $90–190
- Website
- https://www.amtrak.com/home.html
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- ifsr@greyhound.com
- Website
- greyhound.com
Bus from Des Moines to St Louis Bus Station
- Ave. Duration
- 8h 20m
- Frequency
- Once daily
- Estimated price
- $60–120
- Website
- https://www.greyhound.com/
Bus from St Louis Bus Station to Memphis Bus Station
- Ave. Duration
- 5h 30m
- Frequency
- Once daily
- Estimated price
- $40–85
- Website
- https://www.greyhound.com/
Bus from Memphis Bus Station to Tupelo
- Ave. Duration
- 1h 45m
- Frequency
- Twice daily
- Estimated price
- $15–29
- Website
- https://www.greyhound.com/
Bus from Memphis Bus Station to Tupelo
- Ave. Duration
- 1h 45m
- Frequency
- Twice daily
- Estimated price
- $15–29
- Website
- https://www.greyhound.com/
Bus from St Louis Bus Station to Memphis Bus Station
- Ave. Duration
- 5h 30m
- Frequency
- Once daily
- Estimated price
- $40–85
- Website
- https://www.greyhound.com/
Bus from Memphis Bus Station to Tupelo
- Ave. Duration
- 1h 45m
- Frequency
- Twice daily
- Estimated price
- $15–29
- Website
- https://www.greyhound.com/
- Phone
- +1 (855) 626-8585
- Website
- https://www.flixbus.com
Bus from St Louis Bus Station to Memphis Bus Station
- Ave. Duration
- 4h 45m
- Frequency
- Once daily
- Estimated price
- $45–80
- Schedules at
- flixbus.com
Bus from St Louis Bus Station to Memphis Bus Station
- Ave. Duration
- 4h 45m
- Frequency
- Once daily
- Estimated price
- $45–80
- Schedules at
- flixbus.com
- Phone
- +1-858-800-8898
- Website
- jeffersonlines.com
Bus from Des Moines to Kansas City
- Ave. Duration
- 3h 30m
- Frequency
- 3 times a day
- Estimated price
- $50–75
- Book at
- https://www.jeffersonlines.com
- Adult
- $50–75
Bus from Kansas City to Memphis Bus Station
- Ave. Duration
- 10h
- Frequency
- 4 times a week
- Estimated price
- $110–160
- Book at
- https://www.jeffersonlines.com
- Adult
- $110–160
Bus from Des Moines to Kansas City
- Ave. Duration
- 3h 30m
- Frequency
- 3 times a day
- Estimated price
- $50–75
- Book at
- https://www.jeffersonlines.com
- Adult
- $50–75
Want to know more about travelling around United States
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Travelling to the US: What do I need to know?
Read the travel guide
Need to know: Greyhound
Read the travel guide
Why you should take the train in the US
Read the travel guide
More Questions & Answers
There are 33+ hotels available in Tupelo.










