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How to get fromIowa to Tupeloby plane, bus (Greyhound, Flixbus), car, bus (Greyhound, Amtrak, Flixbus), bus, or train

Find Transport to Tupelo

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There are 7 ways to get from Iowa to Tupelo by plane, bus (Greyhound, Flixbus), car, bus (Greyhound, Amtrak, Flixbus), bus, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Des Moines to Tupelo Regional Airport

    best
    1. Fly from Des Moines (DSM) to Tupelo Regional Airport (TUP)plane plane DSM - TUP
    4h 29m
    $128–591

  2. Fly Quad City International Airport to Golden Triangle Regional Airport, drive

    cheapest
    1. Fly from Quad City International Airport (MLI) to Golden Triangle Regional Airport (GTR)plane plane MLI - GTR
    2. Drive from Golden Triangle Regional Airport (GTR) to Tupelocar car
    8h 15m
    $92–448

  3. Bus via Kansas City

    1. Take the bus from Des Moines to Kansas Citybus bus
    2. Take the bus from Kansas City Bus Station to St Louis Bus Stationbus bus
    3. Take the bus from St Louis Bus Station to Memphis Bus Stationbus bus
    4. Take the bus from Memphis Bus Station to Tupelobus bus
    17h 49m
    $172–264

  4. Drive  681.7 mi

    1. Drive from Des Moines to Tupelocar car 681.7 mi
    12h 45m
    $117–169

  5. Fly Omaha to Tupelo Regional Airport

    1. Fly from Omaha (OMA) to Tupelo Regional Airport (TUP)plane plane OMA - TUP
    7h 31m
    $117–571

  6. Bus

    1. Take the bus from Des Moines to Galesburgbus bus
    2. Take the bus from Galesburg Amtrak Station to Springfieldbus bus
    3. Take the bus from Springfield SMTD Transfer Center to Memphis Bus Stationbus bus
    4. Take the bus from Memphis Bus Station to Tupelobus bus
    18h 51m

  7. Bus, train

    1. Take the bus from Des Moines to Kansas Citybus bus
    2. Take the train from Kansas City to St. Louistrain train
    3. Take the bus from St Louis Bus Station to Memphis Bus Stationbus bus
    4. Take the bus from Memphis Bus Station to Tupelobus bus
    20h 9m
    $277–434

Des Moines (DSM) to Tupelo Regional Airport (TUP) flights

Calendar16Weekly Planes
Duration6h 31mAverage Duration
Ticket$95Cheapest Price
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Comparing Your Travel Options

Map of how to get from Iowa to Tupelo.ExpandLaunch map view
  • Distance: 578.9 mi
  • Duration: 4h 29m

What companies run services between Iowa, USA and Tupelo, MS, USA?

Southwest Airlines, Corporate Flight Management Inc, and three other airlines fly from Des Moines (DSM) to Tupelo Regional Airport (TUP) twice daily. Alternatively, you can take a bus from Des Moines to Tupelo via Kansas City, Kansas City Bus Station, St Louis Bus Station, Memphis Bus Station, and Tupelo in around 17h 49m.

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