There are 7 ways to get from Iowa to St. Louis by plane, bus (Greyhound), bus, train, car, or bus (Greyhound, Amtrak, Flixbus)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly from Des Moines
best- Fly from Des Moines (DSM) to Lambert–St. Louis International Airport (STL)plane DSM - STL
4h 34m$131–674Drive 329.8 mi
cheapest- Drive from Des Moines to St. Louiscar 329.8 mi
6h 39m$61–87Bus via Kansas City
- Take the bus from Des Moines to Kansas Citybus Jefferson Lines 803 / ...
- Take the bus from Kansas City Bus Station to St Louis Bus Stationbus Greyhound US0180s / ...
8h 30m$88–137Bus, train
- Take the bus from Des Moines to Kansas Citybus Jefferson Lines 803 / ...
- Take the train from Kansas City to St. Louistrain Missouri River Runner / ...
10h 50m$123–242Line 41 bus to Omaha, fly
- Take the bus from 1st Ave & 8th St NE to 11th & Dodge NEbus
- Fly from Omaha (OMA) to Lambert–St. Louis International Airport (STL)plane OMA - STL
4h 42m$606–906Fly from Quad City International Airport
- Fly from Quad City International Airport (MLI) to Lambert–St. Louis International Airport (STL)plane MLI - STL
6h 44m$75–455Bus
- Take the bus from Des Moines to Galesburgbus
- Take the bus from Galesburg Amtrak Station to Springfieldbus
- Take the bus from Springfield SMTD Transfer Center to St Louis Bus Stationbus
10h 52m$85–140
Iowa to St. Louis by bus
Questions & Answers
The cheapest way to get from Iowa to St. Louis is to drive which costs $60 - $90 and takes 6h 39m.
The fastest way to get from Iowa to St. Louis is to fly which takes 4h 34m and costs $130 - $700.
No, there is no direct bus from Iowa to St. Louis station. However, there are services departing from Des Moines and arriving at St Louis Bus Station via Kansas City Bus Station. The journey, including transfers, takes approximately 8h 30m.
The distance between Iowa and St. Louis is 282 miles. The road distance is 331.7 miles.
The best way to get from Iowa to St. Louis without a car is to bus via Kansas City which takes 8h 30m and costs $85 - $140.
It takes approximately 4h 34m to get from Iowa to St. Louis, including transfers.
Iowa to St. Louis bus services, operated by Jefferson Lines, depart from Des Moines station.
The best way to get from Iowa to St. Louis is to fly which takes 4h 34m and costs $130 - $700. Alternatively, you can bus via Kansas City, which costs $85 - $140 and takes 8h 30m.
Iowa to St. Louis bus services, operated by Jefferson Lines, arrive at Kansas City station.
Yes, the driving distance between Iowa to St. Louis is 332 miles. It takes approximately 6h 39m to drive from Iowa to St. Louis.
What companies run services between Iowa, USA and St. Louis, MO, USA?
Southwest Airlines, United Airlines, and two other airlines fly from Des Moines (DSM) to Lambert–St. Louis International Airport (STL) hourly. Alternatively, you can take a bus from Des Moines to St Louis Bus Station via Kansas City and Kansas City Bus Station in around 8h 30m.
- Website
- aa.com
Flights from Des Moines to Lambert–St. Louis International Airport via Dallas/Ft.Worth
- Ave. Duration
- 5h 29m
- When
- Every day
- Estimated price
- $180–850
Flights from Des Moines to Lambert–St. Louis International Airport via Chicago O'Hare
- Ave. Duration
- 5h 30m
- When
- Every day
- Estimated price
- $110–650
Flights from Quad City International Airport to Lambert–St. Louis International Airport via Chicago O'Hare
- Ave. Duration
- 4h 38m
- When
- Every day
- Estimated price
- $70–450
Flights from Quad City International Airport to Lambert–St. Louis International Airport via Dallas/Ft.Worth
- Ave. Duration
- 6h 22m
- When
- Every day
- Estimated price
- $140–700
Flights from Quad City International Airport to Lambert–St. Louis International Airport via Charlotte
- Ave. Duration
- 7h 39m
- When
- Every day
- Estimated price
- $140–700
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from Kansas City to St. Louis
- Ave. Duration
- 5h 40m
- Frequency
- Twice daily
- Estimated price
- $70–170
- Website
- Amtrak
- Phone
- +1-858-800-8898
- Website
- jeffersonlines.com
Bus from Des Moines to Kansas City
- Ave. Duration
- 3h 30m
- Frequency
- 3 times a day
- Estimated price
- $50–75
- Book at
- Jefferson Lines
- Adult
- $50–75
Bus from Des Moines to Kansas City
- Ave. Duration
- 3h 30m
- Frequency
- 3 times a day
- Estimated price
- $50–75
- Book at
- Jefferson Lines
- Adult
- $50–75
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