Rome2Rio

How to get fromIowa to St. Louisby plane, bus (Greyhound), bus, train or car

Find Transport to St. Louis

See all options

There are 6 ways to get from Iowa to St. Louis by plane, bus (Greyhound), bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Des Moines

    best
    1. Fly from Des Moines (DSM) to Lambert–St. Louis International Airport (STL)plane plane DSM - STL
    4h 19m
    $221–1,224

  2. Drive 329.8 mi

    cheapest
    1. Drive from Des Moines to St. Louiscar car 329.8 mi
    6h 39m
    $61–87

  3. Bus

    1. Take the bus from Des Moines to Kansas Citybus bus Jefferson 803 / ...
    2. Take the bus from Kansas City Bus Station to St Louis Bus Stationbus bus Greyhound US0136 / ...
    8h 35m
    $67–180

  4. Bus, train

    1. Take the bus from Des Moines to Kansas Citybus bus Jefferson 803 / ...
    2. Take the train from Kansas City to St. Louistrain train Missouri River Runner / ...
    11h 25m
    $92–260

  5. Line 41 bus to Omaha, fly

    1. Take the bus from 1st Ave & 8th St NE to 11th & Dodge NEbus bus
    2. Fly from Omaha (OMA) to Lambert–St. Louis International Airport (STL)plane plane OMA - STL
    4h 44m
    $156–1,006

  6. Fly from Quad City International Airport

    1. Fly from Quad City International Airport (MLI) to Lambert–St. Louis International Airport (STL)plane plane MLI - STL
    6h 25m
    $105–655

Des Moines (DSM) to Lambert–St. Louis International Airport (STL) flights

Calendar127Weekly Planes
Duration5h 20mAverage Duration
Ticket$203Cheapest Price
See schedules

Questions & Answers

What companies run services between Iowa, USA and St. Louis, MO, USA?

Southwest Airlines, American Airlines, and two other airlines fly from Des Moines (DSM) to Lambert–St. Louis International Airport (STL) hourly. Alternatively, you can take a vehicle from Des Moines to St Louis Bus Station via Des Moines and Kansas City Bus Station in around 8h 35m.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

Trips from Iowa

Trips to St. Louis

Popular routes