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How to get fromIowa to St. Louisby plane, bus (Greyhound), bus, train, car, or bus (Greyhound, Amtrak, Flixbus)

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There are 7 ways to get from Iowa to St. Louis by plane, bus (Greyhound), bus, train, car, or bus (Greyhound, Amtrak, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Des Moines

    best
    1. Fly from Des Moines (DSM) to Lambert–St. Louis International Airport (STL)plane plane DSM - STL
    4h 34m
    $131–674

  2. Drive  329.8 mi

    cheapest
    1. Drive from Des Moines to St. Louiscar car 329.8 mi
    6h 39m
    $61–87

  3. Bus via Kansas City

    1. Take the bus from Des Moines to Kansas Citybus bus Jefferson Lines 803 / ...
    2. Take the bus from Kansas City Bus Station to St Louis Bus Stationbus bus Greyhound US0180s / ...
    8h 30m
    $88–137

  4. Bus, train

    1. Take the bus from Des Moines to Kansas Citybus bus Jefferson Lines 803 / ...
    2. Take the train from Kansas City to St. Louistrain train Missouri River Runner / ...
    10h 50m
    $123–242

  5. Line 41 bus to Omaha, fly

    1. Take the bus from 1st Ave & 8th St NE to 11th & Dodge NEbus bus
    2. Fly from Omaha (OMA) to Lambert–St. Louis International Airport (STL)plane plane OMA - STL
    4h 42m
    $606–906

  6. Fly from Quad City International Airport

    1. Fly from Quad City International Airport (MLI) to Lambert–St. Louis International Airport (STL)plane plane MLI - STL
    6h 44m
    $75–455

  7. Bus

    1. Take the bus from Des Moines to Galesburgbus bus
    2. Take the bus from Galesburg Amtrak Station to Springfieldbus bus
    3. Take the bus from Springfield SMTD Transfer Center to St Louis Bus Stationbus bus
    10h 52m
    $85–140

Iowa to St. Louis by bus

Calendar18Weekly Buses
Duration8h 30mAverage Duration
Ticket$88Cheapest Price
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Questions & Answers

Map of how to get from Iowa to St. Louis.ExpandLaunch map view
  • Distance: 279.9 mi
  • Duration: 4h 34m

What companies run services between Iowa, USA and St. Louis, MO, USA?

Southwest Airlines, United Airlines, and two other airlines fly from Des Moines (DSM) to Lambert–St. Louis International Airport (STL) hourly. Alternatively, you can take a bus from Des Moines to St Louis Bus Station via Kansas City and Kansas City Bus Station in around 8h 30m.

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Want to know more about travelling around United States

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