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How to get fromIowa to St. LouisBy plane, bus (Greyhound), car, or bus

Find Transport to St. Louis

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There are 5 ways to get from Iowa to St. Louis by plane, bus (Greyhound), car, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Des Moines

    best
    1. Fly from Des Moines (DSM) to Lambert–St. Louis International Airport (STL)plane plane DSM - STL
    4h 34m
    $151–824

  2. Drive 329.8 mi

    cheapest
    1. Drive from Des Moines to St. Louiscar car 329.8 mi
    6h 39m
    $61–87

  3. Bus (Greyhound)

    1. Take the bus from Des Moines to St Louis Bus Stationbus bus Greyhound US0153S
    8h 20m
    $74–140

  4. Line 41 bus to Omaha, fly

    1. Take the bus from 1st Ave & 8th St NE to 11th & Dodge NEbus bus
    2. Fly from Omaha (OMA) to Lambert–St. Louis International Airport (STL)plane plane OMA - STL
    4h 42m
    $116–806

  5. Fly from Quad City International Airport

    1. Fly from Quad City International Airport (MLI) to Lambert–St. Louis International Airport (STL)plane plane MLI - STL
    6h 32m
    $90–605

Des Moines (DSM) to Lambert–St. Louis International Airport (STL) flights

Calendar153Weekly Planes
Duration5h 9mAverage Duration
Ticket$135Cheapest Price
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Questions & Answers

What companies run services between Iowa, USA and St. Louis, MO, USA?

Southwest Airlines, Delta, and three other airlines fly from Des Moines (DSM) to Lambert–St. Louis International Airport (STL) hourly. Alternatively, Greyhound USA operates a bus from Des Moines to St Louis Bus Station once daily. Tickets cost $65–130 and the journey takes 8h 15m.

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