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How to get fromIowa to Ohioby plane, bus (Greyhound), car, bus, bus (Greyhound, Flixbus), or train

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There are 10 ways to get from Iowa to Ohio by plane, bus (Greyhound), car, bus, bus (Greyhound, Flixbus), or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Quad City International Airport to Cleveland-Hopkins International Airport

    best
    1. Fly from Quad City International Airport (MLI) to Cleveland-Hopkins International Airport (CLE)plane plane MLI - CLE
    6h 32m
    $90–495

  2. Bus (Greyhound)

    1. Take the bus from Des Moines to Indianapolis Union Stationbus bus Greyhound US0157S
    2. Take the bus from Indianapolis Union Station to Columbusbus bus Greyhound US0421
    15h 25m
    $107–205

  3. Drive 619.4 mi

    1. Drive from Des Moines to Columbuscar car 619.4 mi
    11h 28m
    $113–164

  4. Fly Des Moines to Detroit, bus

    1. Fly from Des Moines (DSM) to Detroit (DTW)plane plane DSM - DTW
    2. Take the bus from Dearborn to Toledobus bus
    5h 23m
    $171–767

  5. Fly Omaha to Cleveland-Hopkins International Airport

    1. Fly from Omaha (OMA) to Cleveland-Hopkins International Airport (CLE)plane plane OMA - CLE
    6h 55m
    $146–756

  6. Fly Quad City International Airport to Dayton

    1. Fly from Quad City International Airport (MLI) to Dayton (DAY)plane plane MLI - DAY
    7h 23m
    $134–854

  7. Fly Omaha to John Glenn Columbus International Airport

    1. Fly from Omaha (OMA) to John Glenn Columbus International Airport (CMH)plane plane OMA - CMH
    7h 15m
    $655–1,506

  8. Fly Omaha to Detroit, bus

    1. Fly from Omaha (OMA) to Detroit (DTW)plane plane OMA - DTW
    2. Take the bus from Dearborn to Toledobus bus
    8h 12m
    $146–699

  9. Bus via Chicago

    1. Take the bus from Des Moines to Chicago Bus Stationbus bus Greyhound US0123S / ...
    2. Take the bus from Chicago Bus Station to Columbusbus bus FlixBus 2511 / ...
    15h 30m
    $114–205

  10. Bus, train

    1. Take the bus from Des Moines to Galesburgbus bus
    2. Take the train from Galesburg Amtrak Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Toledotrain train
    4. Take the bus from Toledo to Columbus - Mound Stbus bus
    17h 19m
    $185–380

Quad City International Airport (MLI) to Cleveland-Hopkins International Airport (CLE) flights

Calendar95Weekly Planes
Duration5h 12mAverage Duration
Ticket$85Cheapest Price
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Questions & Answers

Map of how to get from Iowa to Ohio.ExpandLaunch map view
  • Distance: 473.2 mi
  • Duration: 6h 32m

What companies run services between Iowa, USA and Ohio, USA?

United Airlines, American Airlines, and Delta fly from Quad City International Airport (MLI) to Cleveland-Hopkins International Airport (CLE) hourly. Alternatively, you can take a vehicle from Des Moines to Columbus via Des Moines and Indianapolis Union Station in around 15h 25m.

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