Rome2Rio

How to get fromIowa to Louisvilleby plane, bus (Greyhound, Amtrak), car, bus, train or bus (Greyhound, Flixbus)

Find Transport to Louisville

See all options

There are 6 ways to get from Iowa to Louisville by plane, bus (Greyhound, Amtrak), car, bus, train, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Des Moines

    best
    1. Fly from Des Moines (DSM) to Louisville International Airport (SDF)plane plane DSM - SDF
    5h 13m
    $169–924

  2. Fly from Quad City International Airport

    cheapest
    1. Fly from Quad City International Airport (MLI) to Louisville International Airport (SDF)plane plane MLI - SDF
    7h 19m
    $78–475

  3. Bus

    1. Take the bus from Des Moines to Chicago Bus Stationbus bus Greyhound US0123 / ...
    2. Take the bus from Chicago Union Station to Louisville, KYbus bus Chicago
    15h 19m
    $99–155

  4. Drive 579.9 mi

    1. Drive from Des Moines to Louisvillecar car 579.9 mi
    9h 44m
    $106–153

  5. Bus, train

    1. Take the bus from Des Moines to Chicago Bus Stationbus bus
    2. Take the train from Chicago Union Station to Indianapolistrain train
    3. Take the bus from Indianapolis Union Station to Louisville, KYbus bus
    16h 38m
    $101–190

  6. Bus via Speedway

    1. Take the bus from Des Moines to Chicago Bus Stationbus bus
    2. Take the bus from Chicago Bus Station to Indianapolisbus bus
    3. Take the bus from Indianapolis to El Mercadito Grocery - Clarksville, INbus bus
    17h 19m
    $132–305

Des Moines (DSM) to Louisville International Airport (SDF) flights

Calendar90Weekly Planes
Duration5h 20mAverage Duration
Ticket$151Cheapest Price
See schedules

Questions & Answers

What companies run services between Iowa, USA and Louisville, KY, USA?

American Airlines, United Airlines, and two other airlines fly from Des Moines (DSM) to Louisville International Airport (SDF) hourly. Alternatively, you can take a vehicle from Des Moines to Louisville, KY via Des Moines, Chicago Bus Station, and Chicago Union Station in around 15h 19m.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

Trips from Iowa

Trips to Louisville

Popular routes