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How to get fromIowa to Kentuckyby plane, bus (Greyhound, Amtrak), bus, train, car, or bus (Greyhound)

Find Transport to Kentucky

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There are 8 ways to get from Iowa to Kentucky by plane, bus (Greyhound, Amtrak), bus, train, car, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Des Moines to Louisville International Airport

    best
    1. Fly from Des Moines (DSM) to Louisville International Airport (SDF)plane plane DSM - SDF
    4h 46m
    $159–824

  2. Fly Quad City International Airport to Louisville International Airport

    cheapest
    1. Fly from Quad City International Airport (MLI) to Louisville International Airport (SDF)plane plane MLI - SDF
    7h 23m
    $93–605

  3. Bus

    1. Take the bus from Des Moines to Indianapolis Union Stationbus bus Greyhound US0157S
    2. Take the bus from Indianapolis Union Station to Louisville Bus Stationbus bus Greyhound US0100 / ...
    12h 35m
    $101–175

  4. Bus, train

    1. Take the bus from Des Moines to Galesburgbus bus
    2. Take the train from Galesburg Amtrak Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Indianapolistrain train
    4. Take the bus from Indianapolis Union Station to Louisville Bus Stationbus bus
    17h 14m
    $151–325

  5. Drive  579.9 mi

    1. Drive from Des Moines to Louisvillecar car 579.9 mi
    9h 44m
    $106–153

  6. Fly Quad City International Airport to Covington

    1. Fly from Quad City International Airport (MLI) to Covington (CVG)plane plane MLI - CVG
    6h 31m
    $94–554

  7. Fly Omaha to Louisville International Airport

    1. Fly from Omaha (OMA) to Louisville International Airport (SDF)plane plane OMA - SDF
    7h 29m
    $144–806

  8. Bus via Speedway

    1. Take the bus from Des Moines to Indianapolis Union Stationbus bus Greyhound US0157S
    2. Take the bus from Indianapolis to El Mercadito Grocery - Clarksville, INbus bus Indianapolis
    15h 17m
    $107–180

Des Moines (DSM) to Louisville International Airport (SDF) flights

Calendar121Weekly Planes
Duration4h 53mAverage Duration
Ticket$141Cheapest Price
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Comparing Your Travel Options

Map of how to get from Iowa to Kentucky.ExpandLaunch map view
  • Distance: 492.4 mi
  • Duration: 4h 46m

What companies run services between Iowa, USA and Kentucky, USA?

Southwest Airlines, United Airlines, and two other airlines fly from Des Moines (DSM) to Louisville International Airport (SDF) hourly. Alternatively, you can take a vehicle from Des Moines to Louisville Bus Station via Des Moines and Indianapolis Union Station in around 12h 35m.

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