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How to get fromIowa to Indianapolisby plane, bus (Greyhound, Flixbus), car, bus or train

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There are 5 ways to get from Iowa to Indianapolis by plane, bus (Greyhound, Flixbus), car, bus, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Des Moines

    best
    1. Fly from Des Moines (DSM) to Indianapolis (IND)plane plane DSM - IND
    4h 52m
    $140–773

  2. Fly from Quad City International Airport

    cheapest
    1. Fly from Quad City International Airport (MLI) to Indianapolis (IND)plane plane MLI - IND
    6h 30m
    $59–374

  4. Bus

    1. Take the bus from Des Moines to Chicago Bus Stationbus bus Greyhound US0123 / ...
    2. Take the bus from Chicago Bus Station to Indianapolisbus bus FlixBus N2640 / ...
    12h
    $80–160

  5. Drive 465.7 mi

    1. Drive from Des Moines to Indianapoliscar car 465.7 mi
    7h 53m
    $85–123

  6. Bus, train

    1. Take the bus from Des Moines to Chicago Bus Stationbus bus Greyhound US0123 / ...
    2. Take the train from Chicago Union Station to Indianapolistrain train Cardinal
    13h 13m
    $99–220

Des Moines (DSM) to Indianapolis (IND) flights

Calendar107Weekly Planes
Duration4h 53mAverage Duration
Ticket$121Cheapest Price
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Questions & Answers

What companies run services between Iowa, USA and Indianapolis, IN, USA?

American Airlines, United Airlines, and two other airlines fly from Des Moines (DSM) to Indianapolis (IND) hourly. Alternatively, you can take a vehicle from Des Moines to Indianapolis via Des Moines and Chicago Bus Station in around 12h.

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Need to know: Greyhound

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