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How to get fromIowa to Indianaby plane, train, bus (Greyhound), car, or bus

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There are 6 ways to get from Iowa to Indiana by plane, train, bus (Greyhound), car, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Des Moines to Chicago O'Hare International Airport, train

    best
    1. Fly from Des Moines (DSM) to Chicago O'Hare International Airport (ORD)plane plane DSM - ORD
    2. Take the train from Van Buren St. to Gary Metro Centertrain train
    3h 52m
    $72–355

  2. Line 60 bus to Quad City International Airport, fly to Chicago O'Hare International Airport, train

    cheapest
    1. Take the bus from District to SouthPark Mall Shelterbus bus
    2. Fly from Quad City International Airport (MLI) to Chicago O'Hare International Airport (ORD)plane plane MLI - ORD
    3. Take the train from Van Buren St. to Gary Metro Centertrain train
    5h 30m
    $37–226

  3. Bus (Greyhound)

    1. Take the bus from Des Moines to Indianapolis Union Stationbus bus Greyhound US0157S
    9h 45m
    $74–140

  4. Drive 465.7 mi

    1. Drive from Des Moines to Indianapoliscar car 465.7 mi
    7h 54m
    $85–123

  5. Fly Des Moines to Chicago Midway International Airport, train

    1. Fly from Des Moines (DSM) to Chicago Midway International Airport (MDW)plane plane DSM - MDW
    2. Take the train from Van Buren St. to Gary Metro Centertrain train
    3h 29m
    $92–465

  6. Fly Omaha to Chicago Midway International Airport, train

    1. Fly from Omaha (OMA) to Chicago Midway International Airport (MDW)plane plane OMA - MDW
    2. Take the train from Van Buren St. to Gary Metro Centertrain train
    6h 2m
    $87–477

Des Moines (DSM) to Chicago O'Hare International Airport (ORD) flights

Calendar83Weekly Planes
Duration2h 3mAverage Duration
Ticket$48Cheapest Price
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Questions & Answers

Map of how to get from Iowa to Indiana.ExpandLaunch map view
  • Distance: 352.2 mi
  • Duration: 3h 52m

What companies run services between Iowa, USA and Indiana, USA?

Greyhound USA operates a bus from Des Moines to Indianapolis Union Station once daily. Tickets cost $65–130 and the journey takes 9h 40m.

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