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How to get fromIowa to Indianaby plane, train, bus (Greyhound), car, or bus

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There are 7 ways to get from Iowa to Indiana by plane, train, bus (Greyhound), car, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Des Moines to Chicago O'Hare International Airport, train

    best
    1. Fly from Des Moines (DSM) to Chicago O'Hare International Airport (ORD)plane plane DSM - ORD
    2. Take the train from Van Buren St. to Gary Metro Centertrain train
    3h 50m
    $77–395

  2. Line 60 bus to Quad City International Airport, fly to Chicago O'Hare International Airport, train

    cheapest
    1. Take the bus from District to SouthPark Mall Shelterbus bus
    2. Fly from Quad City International Airport (MLI) to Chicago O'Hare International Airport (ORD)plane plane MLI - ORD
    3. Take the train from Van Buren St. to Gary Metro Centertrain train
    5h 28m
    $37–226

  3. Bus (Greyhound)

    1. Take the bus from Des Moines to Indianapolis Union Stationbus bus Greyhound US0157S
    10h 5m
    $74–150

  4. Drive 465.7 mi

    1. Drive from Des Moines to Indianapoliscar car 465.7 mi
    7h 53m
    $85–123

  5. Fly Des Moines to Chicago Midway International Airport, train

    1. Fly from Des Moines (DSM) to Chicago Midway International Airport (MDW)plane plane DSM - MDW
    2. Take the train from Van Buren St. to Gary Metro Centertrain train
    3h 29m
    $102–535

  6. Fly Omaha to Chicago Midway International Airport, train

    1. Fly from Omaha (OMA) to Chicago Midway International Airport (MDW)plane plane OMA - MDW
    2. Take the train from Van Buren St. to Gary Metro Centertrain train
    6h 2m
    $92–507

  7. Bus to The Eastern Iowa Airport, fly to Chicago O'Hare International Airport, train

    1. Take the bus from Court St Transportation Center to GTC Bay 9bus bus
    2. Fly from The Eastern Iowa Airport (CID) to Chicago O'Hare International Airport (ORD)plane plane CID - ORD
    3. Take the train from Van Buren St. to Gary Metro Centertrain train
    6h 34m

Des Moines (DSM) to Chicago O'Hare International Airport (ORD) flights

Calendar77Weekly Planes
Duration1h 41mAverage Duration
Ticket$54Cheapest Price
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Questions & Answers

Map of how to get from Iowa to Indiana.ExpandLaunch map view
  • Distance: 352.2 mi
  • Duration: 3h 50m

What companies run services between Iowa, USA and Indiana, USA?

Greyhound USA operates a bus from Des Moines to Indianapolis Union Station twice daily. Tickets cost $65–140 and the journey takes 10h.

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