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How to get fromIowa to Chicagoby plane, bus (Greyhound), car, bus, or train

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There are 7 ways to get from Iowa to Chicago by plane, bus (Greyhound), car, bus, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Des Moines to Chicago O'Hare International Airport

    best
    1. Fly from Des Moines (DSM) to Chicago O'Hare International Airport (ORD)plane plane DSM - ORD
    2h 36m
    $70–386

  2. Line 60 bus to Quad City International Airport, fly to Chicago O'Hare International Airport

    cheapest
    1. Take the bus from District to SouthPark Mall Shelterbus bus
    2. Fly from Quad City International Airport (MLI) to Chicago O'Hare International Airport (ORD)plane plane MLI - ORD
    4h 10m
    $30–217

  3. Bus (Greyhound)

    1. Take the bus from Des Moines to Chicago Bus Stationbus bus Greyhound US0123S / ...
    7h 10m
    $54–110

  4. Drive 330.7 mi

    1. Drive from Des Moines to Chicagocar car 330.7 mi
    5h 33m
    $61–88

  5. Fly Des Moines to Chicago Midway International Airport

    1. Fly from Des Moines (DSM) to Chicago Midway International Airport (MDW)plane plane DSM - MDW
    2h 13m
    $95–526

  6. Line 41 bus to Omaha, fly to Chicago Midway International Airport

    1. Take the bus from 1st Ave & 8th St NE to 11th & Dodge NEbus bus
    2. Fly from Omaha (OMA) to Chicago Midway International Airport (MDW)plane plane OMA - MDW
    4h 46m
    $85–498

  7. Bus, train

    1. Take the bus from Des Moines to Galesburgbus bus Greyhound US0157S
    2. Take the train from Galesburg Amtrak Station to Chicago Union Stationtrain train Carl Sandburg / ...
    8h 45m
    $84–170

Des Moines (DSM) to Chicago O'Hare International Airport (ORD) flights

Calendar77Weekly Planes
Duration2h 5mAverage Duration
Ticket$54Cheapest Price
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Questions & Answers

Map of how to get from Iowa to Chicago.ExpandLaunch map view
  • Distance: 322.1 mi
  • Duration: 2h 36m

What companies run services between Iowa, USA and Chicago, IL, USA?

American Airlines, United Airlines, and Delta fly from Des Moines (DSM) to Chicago O'Hare International Airport (ORD) every 2 hours. Alternatively, Greyhound USA operates a bus from Des Moines to Chicago Bus Station 5 times a day. Tickets cost $45–100 and the journey takes 7h 5m.

Airlines
Train operators
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