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How to get fromIowa to Chicagoby plane, bus (Greyhound), car or bus

Find Transport to Chicago

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There are 5 ways to get from Iowa to Chicago by plane, bus (Greyhound), car, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Des Moines

    best
    1. Fly from Des Moines (DSM) to Chicago O'Hare International Airport (ORD)plane plane DSM - ORD
    2h 32m
    $80–446
  2. Line 60 bus to Quad City International Airport, fly

    cheapest
    1. Take the bus from District to SouthPark Mall Shelterbus bus
    2. Fly from Quad City International Airport (MLI) to Chicago O'Hare International Airport (ORD)plane plane MLI - ORD
    4h 13m
    $34–227
  3. Bus (Greyhound)

    1. Take the bus from Des Moines to Chicago Bus Stationbus bus Greyhound US0123 / ...
    7h 10m
    $49–110
  4. Drive 330.7 mi

    1. Drive from Des Moines to Chicagocar car 330.7 mi
    5h 33m
    $61–88
  5. Fly from Waterloo Municipal Airport

    1. Fly from Waterloo Municipal Airport (ALO) to Chicago O'Hare International Airport (ORD)plane plane ALO - ORD
    2h 21m
    $56–267

Des Moines (DSM) to Chicago O'Hare International Airport (ORD) flights

Calendar50Weekly Planes
Duration1h 38mAverage Duration
Ticket$64Cheapest Price
See schedules

Questions & Answers

What companies run services between Iowa, USA and Chicago, IL, USA?

American Airlines and United Airlines fly from Des Moines (DSM) to Chicago O'Hare International Airport (ORD) every 4 hours. Alternatively, Greyhound USA operates a bus from Des Moines to Chicago Bus Station 3 times a day. Tickets cost $40–100 and the journey takes 7h 5m.

Airlines
Bus operators

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Need to know: Greyhound

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