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How to get fromIowa to Chicagoby plane, bus (Greyhound), car, bus or train

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There are 9 ways to get from Iowa to Chicago by plane, bus (Greyhound), car, bus, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Des Moines

    best
    1. Fly from Des Moines (DSM) to Chicago O'Hare International Airport (ORD)planeDSM - ORD
    2h 34m
    $85–436

  2. Line 60 bus to Quad City International Airport, fly

    cheapest
    1. Take the bus from District to SouthPark Mall Shelterbus
    2. Fly from Quad City International Airport (MLI) to Chicago O'Hare International Airport (ORD)planeMLI - ORD
    4h 13m
    $34–227

  3. Bus via Des Moines (Greyhound)

    1. Take the bus from Des Moines to Chicago Bus StationbusGreyhound US0123 / ...
    7h 10m
    $64–130

  4. Drive 330.7 mi

    1. Drive from Des Moines to Chicagocar330.7 mi
    5h 30m
    $61–88

  5. Fly from Waterloo Municipal Airport

    1. Fly from Waterloo Municipal Airport (ALO) to Chicago O'Hare International Airport (ORD)planeALO - ORD
    2h 23m
    $56–267

  6. Fly from The Eastern Iowa Airport

    1. Fly from The Eastern Iowa Airport (CID) to Chicago O'Hare International Airport (ORD)planeCID - ORD
    3h 45m
    $54–275

  7. Bus

    1. Take the bus from Des Moines to ChicagobusDes Moines
    7h 15m
    $55–160

  8. Bus #2

    1. Take the bus from Des Moines to ChicagobusOmaha
    7h 28m
    $67–152

  9. Bus, train

    1. Take the bus from Des Moines to Burlingtonbus
    2. Take the bus from Burlington to Galesburgbus
    3. Take the train from Galesburg Amtrak Station to Chicago Union Stationtrain
    8h 55m
    $90–212

Iowa to Chicago by bus

Calendar14Weekly Buses
Duration7h 15mAverage Duration
Ticket$55Cheapest Price
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Questions & Answers

What companies run services between Iowa, USA and Chicago, IL, USA?

American Airlines and United Airlines fly from Des Moines (DSM) to Chicago O'Hare International Airport (ORD) every 4 hours. Alternatively, Greyhound USA operates a bus from Des Moines to Chicago Bus Station 3 times a day. Tickets cost $55–120 and the journey takes 7h 5m.

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