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How to get fromIowa to Buffaloby plane, bus (Greyhound), bus, train or car

Find Transport to Buffalo

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There are 7 ways to get from Iowa to Buffalo by plane, bus (Greyhound), bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Des Moines

    best
    1. Fly from Des Moines (DSM) to Buffalo Niagara International Airport (BUF)plane plane DSM - BUF
    5h 21m
    $372–2,001

  2. Bus

    cheapest
    1. Take the bus from Des Moines to Chicago Bus Stationbus bus
    2. Take the bus from Chicago Bus Station to Cleveland Bus Stationbus bus
    3. Take the bus from Cleveland, OH to Buffalo, NYbus bus
    19h 30m
    $97–255

  3. Bus, train

    1. Take the bus from Des Moines to Chicago Bus Stationbus bus Greyhound US0123 / ...
    2. Take the train from Chicago Union Station to Buffalo Depew Stationtrain train Lake Shore Limited
    20h 3m
    $113–385

  4. Drive 848.1 mi

    1. Drive from Des Moines to Buffalocar car 848.1 mi
    14h 16m
    $155–224

  5. Fly from Waterloo Municipal Airport

    1. Fly from Waterloo Municipal Airport (ALO) to Buffalo Niagara International Airport (BUF)plane plane ALO - BUF
    7h 57m
    $223–1,202

  6. Fly from Quad City International Airport

    1. Fly from Quad City International Airport (MLI) to Buffalo Niagara International Airport (BUF)plane plane MLI - BUF
    7h 35m
    $186–1,182

  7. Fly from Omaha

    1. Fly from Omaha (OMA) to Buffalo Niagara International Airport (BUF)plane plane OMA - BUF
    8h 18m
    $397–2,083

Des Moines (DSM) to Buffalo Niagara International Airport (BUF) flights

Calendar40Weekly Planes
Duration5h 41mAverage Duration
Ticket$358Cheapest Price
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Questions & Answers

What companies run services between Iowa, USA and Buffalo, NY, USA?

Delta, American Airlines, and United Airlines fly from Des Moines (DSM) to Buffalo Niagara International Airport (BUF) every 4 hours. Alternatively, you can take a vehicle from Des Moines to Buffalo, NY via Des Moines, Chicago Bus Station, Cleveland Bus Station, and Cleveland, OH in around 19h 30m.

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Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

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