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How to get fromIowa to BuffaloBy plane, bus (Greyhound), bus, train, or car

Find Transport to Buffalo

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There are 7 ways to get from Iowa to Buffalo by plane, bus (Greyhound), bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Des Moines

    best
    1. Fly from Des Moines (DSM) to Buffalo Niagara International Airport (BUF)plane plane DSM - BUF
    5h 14m
    $313–1,649

  2. Bus

    cheapest
    1. Take the bus from Des Moines to Chicago Bus Stationbus bus
    2. Take the bus from Chicago to Clevelandbus bus
    3. Take the bus from Cleveland, OH to Buffalo, NYbus bus
    19h 15m
    $107–260

  3. Bus, train

    1. Take the bus from Des Moines to Chicago Bus Stationbus bus Greyhound US0123S / ...
    2. Take the train from Chicago Union Station to Buffalo Depew Stationtrain train Lake Shore Limited
    20h 3m
    $208–505

  4. Drive 847.5 mi

    1. Drive from Des Moines to Buffalocar car 847.5 mi
    14h 18m
    $155–224

  5. Fly from Quad City International Airport

    1. Fly from Quad City International Airport (MLI) to Buffalo Niagara International Airport (BUF)plane plane MLI - BUF
    7h 11m
    $197–1,130

  6. Fly from Omaha

    1. Fly from Omaha (OMA) to Buffalo Niagara International Airport (BUF)plane plane OMA - BUF
    7h 42m
    $378–1,931

  7. Bus, train via Bloomington

    1. Take the bus from Des Moines to Bloomington-Normalbus bus
    2. Take the train from Bloomington-Normal to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Buffalo Depew Stationtrain train
    22h 23m
    $233–560

Des Moines (DSM) to Buffalo Niagara International Airport (BUF) flights

Calendar87Weekly Planes
Duration5h 7mAverage Duration
Ticket$297Cheapest Price
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Questions & Answers

What companies run services between Iowa, USA and Buffalo, NY, USA?

Southwest Airlines, Delta, and two other airlines fly from Des Moines (DSM) to Buffalo Niagara International Airport (BUF) every 2 hours. Alternatively, you can take a vehicle from Des Moines to Buffalo, NY via Des Moines, Chicago, and Cleveland, OH in around 19h 15m.

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Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

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