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How to get fromIowa to Buffaloby plane, bus (Greyhound), bus, train, car or bus (Greyhound, Flixbus)

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There are 10 ways to get from Iowa to Buffalo by plane, bus (Greyhound), bus, train, car, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Des Moines

    best
    1. Fly from Des Moines (DSM) to Buffalo Niagara International Airport (BUF)planeDSM - BUF
    5h 32m
    $382–2,001

  2. Bus via Cleveland

    cheapest
    1. Take the bus from Des Moines to Chicagobus
    2. Take the bus from Chicago Bus Station to Cleveland Bus Stationbus
    3. Take the bus from Cleveland, OH to Buffalo, NYbus
    19h 48m
    $115–312

  3. Bus, train

    1. Take the bus from Des Moines to ChicagobusOmaha
    2. Take the train from Chicago Union Station to Buffalo Depew StationtrainLake Shore Limited
    20h 21m
    $131–437

  4. Drive 848.1 mi

    1. Drive from Des Moines to Buffalocar848.1 mi
    14h 8m
    $155–224

  5. Fly from The Eastern Iowa Airport

    1. Fly from The Eastern Iowa Airport (CID) to Buffalo Niagara International Airport (BUF)planeCID - BUF
    7h 14m
    $226–1,220

  6. Fly from Quad City International Airport

    1. Fly from Quad City International Airport (MLI) to Buffalo Niagara International Airport (BUF)planeMLI - BUF
    8h 26m
    $196–1,182

  7. Fly from Omaha

    1. Fly from Omaha (OMA) to Buffalo Niagara International Airport (BUF)planeOMA - BUF
    7h 46m
    $407–2,183

  8. Bus, train via Walden Avenue & Thruway Transit Center

    1. Take the bus from Des Moines to ChicagobusDes Moines
    2. Take the train from Chicago Union Station to Buffalo Depew StationtrainLake Shore Limited
    20h 28m
    $115–368

  9. Bus, train via Galesburg

    1. Take the bus from Des Moines to Burlingtonbus
    2. Take the bus from Burlington to Galesburgbus
    3. Take the train from Galesburg Amtrak Station to Chicago Union Stationtrain
    4. Take the train from Chicago Union Station to Buffalo Depew Stationtrain
    21h 39m
    $154–497

  10. Bus

    1. Take the bus from Des Moines to Chicago Bus Stationbus
    2. Take the bus from Chicago Bus Station to Detroit Bus Stationbus
    3. Take the bus from Detroit Bus Station to Torontobus
    4. Take the bus from Toronto to Buffalobus
    25h 25m
    $153–385

Iowa to Buffalo by bus and foot

Calendar7Weekly Services
Duration19h 48mAverage Duration
Ticket$115Cheapest Price
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Questions & Answers

What companies run services between Iowa, USA and Buffalo, NY, USA?

Delta, United Airlines, and two other airlines fly from Des Moines (DSM) to Buffalo Niagara International Airport (BUF) every 4 hours. Alternatively, you can take a bus from Pennsylvania Ave / E University Ave to Buffalo, NY via 7Th St / Locust St, Dsm, Des Moines, Chicago Bus Station, Cleveland Bus Station, and Cleveland, OH in around 19h 48m.

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