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How to get fromIowa to Buffaloby plane, bus (Greyhound), bus, train, or car

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Iowa to Buffalo

Rome2Rio compared 6 ways to get from Iowa to Buffalo. The best route is Fly from Des Moines, a distance of 1188.5 km.

  1. Fly from Des Moines

    best
    1. Fly from Des Moines (DSM) to Buffalo Niagara International Airport (BUF)plane plane DSM - BUF
    4h 56m
    $240–1,250

  2. Bus

    cheapest
    1. Take the bus from Des Moines to Chicago Bus Stationbus bus
    2. Take the bus from Chicago to Clevelandbus bus
    3. Take the bus from Cleveland, OH to Buffalo, NYbus bus
    19h 15m
    $107–245

  3. Bus, train

    1. Take the bus from Des Moines to Chicago Bus Stationbus bus Greyhound US0123S / ...
    2. Take the train from Chicago Union Station to Buffalo Depew Stationtrain train Lake Shore Limited
    20h 3m
    $231–585

  4. Drive 847.5 mi

    1. Drive from Des Moines to Buffalocar car 847.5 mi
    14h 18m
    $155–224

  5. Fly from Quad City International Airport

    1. Fly from Quad City International Airport (MLI) to Buffalo Niagara International Airport (BUF)plane plane MLI - BUF
    7h 6m
    $144–831

  6. Bus, train via Galesburg

    1. Take the bus from Des Moines to Galesburgbus bus
    2. Take the train from Galesburg Amtrak Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Buffalo Depew Stationtrain train
    21h 14m
    $261–660

Des Moines (DSM) to Buffalo Niagara International Airport (BUF) flights

Calendar85Weekly Planes
Duration5h 18mAverage Duration
Ticket$228Cheapest Price
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Questions & Answers

Map of how to get from Iowa to Buffalo.ExpandLaunch map view
  • Distance: 788.9 mi
  • Duration: 4h 56m

What companies run services between Iowa, USA and Buffalo, NY, USA?

Southwest Airlines, Delta, and two other airlines fly from Des Moines (DSM) to Buffalo Niagara International Airport (BUF) every 2 hours. Alternatively, you can take a vehicle from Des Moines to Buffalo, NY via Des Moines, Chicago, and Cleveland, OH in around 19h 15m.

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