Directions from Iowa City to St. Louis

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Bus via Burlington, IA  •  7 h 20 min

  1. 1490
  2. 1490

$73 - $146

Cheapest option

Bus  •  8 h 35 min

  1. 1490

$50 - $100

5 alternative options

Bus, train  •  9 h 33 min

$91 - $171

Drive  •  4 h 54 min

  1. 261.9 miles

$25 - $40

Bus to Burlington, fly  •  4 h 23 min

  1. BRL - STL

$99 - $212

Fly from Cedar Rapids  •  5 h 34 min

  1. CID - STL

$264 - $1,333

Bus to Des Moines, fly  •  6 h 24 min

  1. DSM - STL

$227 - $949

What companies run services between Iowa City, IA, USA and St. Louis, MO, USA?

You can take a bus from Iowa City to St. Louis via Burlington, IA in around 7 h 20 min. Alternatively, American Airlines, United Airlines and Delta fly from Iowa City to St. Louis hourly.

Airlines
Delta
Website
delta.com
Flights from Cedar Rapids to St. Louis via Minneapolis
Ave. Duration
4 h 57 min
When
Every day
Estimated price
$250 - $1,300
Flights from Cedar Rapids to St. Louis via Detroit
Ave. Duration
5 h 21 min
When
Every day
Estimated price
$270 - $1,300
Flights from Cedar Rapids to St. Louis via Atlanta
Ave. Duration
5 h 29 min
When
Every day
Estimated price
$300 - $1,400
American Airlines
Website
aa.com
Flights from Cedar Rapids to St. Louis via Chicago O'Hare
Ave. Duration
4 h
When
Every day
Estimated price
$240 - $1,300
Flights from Cedar Rapids to St. Louis via Dallas/Ft.Worth
Ave. Duration
4 h 58 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$330 - $1,400
Flights from Cedar Rapids to St. Louis via Charlotte
Ave. Duration
6 h 2 min
When
Every day
Estimated price
$340 - $1,400
United Airlines
Website
united.com
Flights from Cedar Rapids to St. Louis via Chicago O'Hare
Ave. Duration
4 h 38 min
When
Every day
Estimated price
$260 - $1,300
Flights from Cedar Rapids to St. Louis via Denver
Ave. Duration
6 h 19 min
When
Every day
Estimated price
$360 - $1,600
Southwest Airlines
Website
southwest.com
Flights from Des Moines to St. Louis
Ave. Duration
58 min
When
Every day
Estimated price
$190 - $900
Air Choice One
Website
airchoiceone.com
Flights from Burlington to St. Louis
Ave. Duration
1 h 10 min
When
Every day
Estimated price
$50 - $140
Train operators
Amtrak
Phone
+1 1-800-872-7245
Website
amtrak.com
Train from Bloomington-Normal Amtrak to St. Louis Gateway Station Amtrak
Ave. Duration
3 h 16 min
Frequency
Every 4 hours
Estimated price
$35 - $85
Website
amtrak.com
Coach Seat
$35 - $55
Flexi Coach Seat
$65 - $95
Business Coach Seat
$60 - $85
Room
$180 - $260
Bus operators
Burlington Trailways
Website
burlingtontrailways.com
Bus from Iowa City, IA to Burlington, IA
Ave. Duration
1 h 25 min
Frequency
Twice daily
Estimated price
$27 - $50
Schedules at
burlingtontrailways.com
Book at
burlingtontrailways.com
Bus from Burlington, IA to St Louis, MO
Ave. Duration
4 h 55 min
Frequency
Once daily
Estimated price
$45 - $100
Schedules at
burlingtontrailways.com
Book at
burlingtontrailways.com
Bus from Iowa City, IA to St Louis, MO
Ave. Duration
8 h 35 min
Frequency
Once daily
Estimated price
$50 - $100
Schedules at
burlingtontrailways.com
Book at
burlingtontrailways.com
Bus from Iowa City, IA to Davenport, IA
Ave. Duration
1 h 12 min
Frequency
Hourly
Estimated price
$25 - $40
Schedules at
burlingtontrailways.com
Book at
burlingtontrailways.com
Bus from Davenport, IA to Bloomington/Normal, IL
Ave. Duration
3 h 5 min
Frequency
Twice daily
Estimated price
$30 - $50
Schedules at
burlingtontrailways.com
Book at
burlingtontrailways.com
Bus from Iowa City, IA to Des Moines, IA
Ave. Duration
2 h 5 min
Frequency
Every 3 hours
Estimated price
$30 - $45
Schedules at
burlingtontrailways.com
Book at
burlingtontrailways.com

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Questions & Answers

The distance between Iowa City and St. Louis is 356 km. The road distance is 419 km.

The cheapest way to get from Iowa City to St. Louis is to drive which costs $25 - $40 and takes 4 h 54 min.

The quickest way to get from Iowa City to St. Louis is to bus and fly which takes 4 h 23 min and costs $95 - $220.

Yes, there is a direct bus departing from Iowa City, IA and arriving at St Louis, MO. Services depart once daily, and operate every day. The journey takes approximately 8 h 35 min.

It takes approximately 7 h 20 min to get from Iowa City to St. Louis, including transfers.