• Our partners include:

  • Greyhound USA
  • VIA Rail
  • Amtrak
  • Acela Express
  • Megabus
  • SuperShuttle
  • Booking.com
  • Skyscanner
  • Airbnb
  • Expedia

There are 6 ways to get from Iowa City to St. Louis by bus, car or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Bus via Burlington, IA  •  8 h 19 min

  1. Take the bus from Iowa City, IA to Mt. Pleasant, IA 1490
  2. Take the bus from Burlington, IA to St Louis, MO 1490

$87 - $165

Cheapest option

Bus  •  8 h 35 min

  1. Take the bus from Iowa City, IA to St Louis, MO 1490

$50 - $100

4 alternative options

Drive  •  4 h 54 min

  1. Drive from Iowa City to St. Louis 261.9 miles

$25 - $40

Fly from Cedar Rapids  •  5 h 30 min

  1. Fly from Cedar Rapids (CID) to St. Louis (STL) CID - STL

$265 - $1,334

Bus to Burlington, fly  •  5 h 19 min

  1. Take the bus from Iowa City, IA to Mt. Pleasant, IA
  2. Fly from Burlington (BRL) to St. Louis (STL) BRL - STL

$121 - $238

Bus to Des Moines, fly  •  6 h 13 min

  1. Take the bus from Iowa City - Coralville to Des Moines, IA
  2. Fly from Des Moines (DSM) to St. Louis (STL) DSM - STL

$195 - $905

Questions & Answers

The cheapest way to get from Iowa City to St. Louis is to drive which costs $25 - $40 and takes 4 h 54 min.

More details

The quickest way to get from Iowa City to St. Louis is to drive which costs $25 - $40 and takes 4 h 54 min.

More details

Yes, there is a direct bus departing from Iowa City, IA and arriving at St Louis, MO. Services depart once daily, and operate every day. The journey takes approximately 8 h 35 min.

More details

The distance between Iowa City and St. Louis is 222 miles. The road distance is 261.9 miles.

Get driving directions

The best way to get from Iowa City to St. Louis without a car is to bus which takes 8 h 19 min and costs $85 - $170.

More details

It takes approximately 8 h 19 min to get from Iowa City to St. Louis, including transfers.

More details

Iowa City to St. Louis bus services, operated by Burlington Trailways, depart from Iowa City, IA station.

More details

The best way to get from Iowa City to St. Louis is to bus which takes 8 h 19 min and costs $85 - $170. Alternatively, you can fly, which costs $260 - $1,400 and takes 5 h 30 min.

Mode details

There is no direct flight from Cedar Rapids Airport to St. Louis Airport. The quickest flight takes 3 h 9 min and has one stopover.

Search flights

Iowa City to St. Louis bus services, operated by Burlington Trailways, arrive at St Louis, MO station.

More details

Map of how to get from Iowa City to St. Louis.
Launch map view
  • Distance: 222.4 miles
  • Duration: 8 h 19 min

What companies run services between Iowa City, IA, USA and St. Louis, MO, USA?

You can take a bus from Iowa City to St. Louis via Mt. Pleasant, IA, Mt. Pleasant, IL, Burlington, IL, and Burlington, IA in around 8 h 19 min. Alternatively, American Airlines, Delta and United Airlines fly from Iowa City to St. Louis hourly.

Airlines
American Airlines
Website
aa.com
Flights from Cedar Rapids to St. Louis via Chicago O'Hare
Ave. Duration
4 h 20 min
When
Every day
Estimated price
$240 - $1,300
Flights from Cedar Rapids to St. Louis via Dallas/Ft.Worth
Ave. Duration
5 h 20 min
When
Monday, Tuesday, Wednesday, Friday, Saturday and Sunday
Estimated price
$330 - $1,400
Flights from Cedar Rapids to St. Louis via Charlotte
Ave. Duration
6 h 1 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$340 - $1,400
Delta
Website
delta.com
Flights from Cedar Rapids to St. Louis via Minneapolis
Ave. Duration
4 h 8 min
When
Every day
Estimated price
$250 - $1,300
Flights from Cedar Rapids to St. Louis via Detroit
Ave. Duration
5 h 18 min
When
Every day
Estimated price
$270 - $1,300
Flights from Cedar Rapids to St. Louis via Atlanta
Ave. Duration
6 h 8 min
When
Every day
Estimated price
$300 - $1,400
United Airlines
Website
united.com
Flights from Cedar Rapids to St. Louis via Chicago O'Hare
Ave. Duration
4 h 23 min
When
Every day
Estimated price
$260 - $1,300
Flights from Cedar Rapids to St. Louis via Denver
Ave. Duration
6 h 14 min
When
Monday, Tuesday, Wednesday, Friday, Saturday and Sunday
Estimated price
$360 - $1,600
Southwest Airlines
Website
southwest.com
Flights from Des Moines to St. Louis
Ave. Duration
1 h
When
Every day
Estimated price
$190 - $900
Air Choice One
Website
airchoiceone.com
Flights from Burlington to St. Louis
Ave. Duration
1 h 10 min
When
Every day
Estimated price
$50 - $140
Bus operators
Burlington Trailways
Website
burlingtontrailways.com
Bus from Iowa City, IA to Mt. Pleasant, IA
Ave. Duration
55 min
Frequency
Once daily
Estimated price
$25 - $35
Schedules at
burlingtontrailways.com
Book at
burlingtontrailways.com
Bus from Burlington, IA to St Louis, MO
Ave. Duration
4 h 55 min
Frequency
Once daily
Estimated price
$40 - $95
Schedules at
burlingtontrailways.com
Book at
burlingtontrailways.com
Bus from Iowa City, IA to St Louis, MO
Ave. Duration
8 h 35 min
Frequency
Once daily
Estimated price
$50 - $100
Schedules at
burlingtontrailways.com
Book at
burlingtontrailways.com
Windstar
Phone
+1 888-494-6378
Email
sara@gowindstar.com
Website
gowindstar.com
Bus from Iowa City - Coralville to Des Moines, IA
Ave. Duration
2 h 25 min
Frequency
Once daily
Schedules at
gowindstar.com

Want to know more about travelling around United States

Rome2rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

More Questions & Answers

Yes, the driving distance between Iowa City to St. Louis is 262 miles. It takes approximately 4 h 54 min to drive from Iowa City to St. Louis.

Get driving directions

United Airlines, American Airlines and Delta offer flights from Cedar Rapids Airport to St. Louis Airport.

Search flights

There are 198+ hotels available in St. Louis. Prices start at $69 USD per night.

More details

The best way to get from Iowa City to Cedar Rapids Airport is to line 1490 bus which takes 40 min and costs $22 - $35.

More details