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How to get fromIowa City to Defianceby bus, train, car, plane or taxi

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There are 6 ways to get from Iowa City to Defiance by bus, train, car, plane, or taxi

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus, train

    best
    1. Take the bus from Iowa City to Chicago Bus Stationbus bus Greyhound US0155S
    2. Take the train from Chicago Union Station to Bryan Amtrak Stationtrain train Lake Shore Limited
    10h 37m
    $140–242

  2. Drive 401.4 mi

    cheapest
    1. Drive from Iowa City to Defiancecar car 401.4 mi
    7h 39m
    $74–106

  3. Bus to Quad City International Airport, fly, taxi

    1. Take the bus from Iowa City to Moline Center Stationbus bus
    2. Fly from Quad City International Airport (MLI) to Fort Wayne International Airport (FWA)plane plane MLI - FWA
    3. Take the taxi from Fort Wayne International Airport (FWA) to Defiancetaxi taxi
    7h 43m
    $191–489

  4. Bus, taxi

    1. Take the bus from Iowa City to Chicago Bus Stationbus bus
    2. Take the bus from Chicago to Van Wertbus bus
    3. Take the taxi from Van Wert to Defiancetaxi taxi
    12h 32m
    $150–252

  5. Bus to The Eastern Iowa Airport, fly, taxi

    1. Take the bus from Court St Transportation Center to GTC Bay 9bus bus
    2. Fly from The Eastern Iowa Airport (CID) to Fort Wayne International Airport (FWA)plane plane CID - FWA
    3. Take the taxi from Fort Wayne International Airport (FWA) to Defiancetaxi taxi
    7h 49m

  6. Bus to Chicago O'Hare International Airport, fly, taxi

    1. Take the bus from Iowa City to Chicago Bus Stationbus bus
    2. Fly from Chicago O'Hare International Airport (ORD) to Fort Wayne International Airport (FWA)plane plane ORD - FWA
    3. Take the taxi from Fort Wayne International Airport (FWA) to Defiancetaxi taxi
    9h 57m
    $211–487

Quad City International Airport (MLI) to Fort Wayne International Airport (FWA) flights

Calendar56Weekly Planes
Duration4h 40mAverage Duration
Ticket$43Cheapest Price
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Questions & Answers

What companies run services between Iowa City, IA, USA and Defiance, OH, USA?

There is no direct connection from Iowa City to Defiance. However, you can take the bus to Chicago Bus Station, walk to Chicago Union Station, take the train to Bryan Amtrak Station, then take the taxi to Defiance. Alternatively, you can drive from Iowa City to Defiance in around 7h 39m.

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