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How to get fromIowa City to Defianceby bus (Greyhound, Amtrak), bus, train, car, plane, or taxi

Find Transport to Defiance

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There are 7 ways to get from Iowa City to Defiance by bus (Greyhound, Amtrak), bus, train, car, plane, or taxi

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from Iowa City to Chicagobus bus Btw 1202 / ...
    2. Take the bus from Chicago Union Station to Bryan Amtrak Stationbus bus Amtrak Thruway Connecting Service
    8h 57m
    $151–233

  2. Drive 401.4 mi

    cheapest
    1. Drive from Iowa City to Defiancecar car 401.4 mi
    7h 39m
    $74–106

  3. Bus, train via Naperville

    1. Take the bus from Iowa City to Napervillebus bus
    2. Take the train from Naperville to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Bryan Amtrak Stationtrain train
    9h 52m

  4. Fly from The Eastern Iowa Airport, taxi

    1. Fly from The Eastern Iowa Airport (CID) to Fort Wayne International Airport (FWA)plane plane CID - FWA
    2. Take the taxi from Fort Wayne International Airport (FWA) to Defiancetaxi taxi
    6h 36m
    $243–794

  5. Bus, train

    1. Take the bus from Iowa City to Chicagobus bus Btw 1202 / ...
    2. Take the train from Chicago Union Station to Bryan Amtrak Stationtrain train Lake Shore Limited
    8h 57m
    $146–258

  6. Bus via Davenport

    1. Take the bus from Iowa City to Davenportbus bus
    2. Take the bus from Davenport to Chicago Bus Stationbus bus
    3. Take the bus from Chicago Union Station to Bryan Amtrak Stationbus bus
    10h 27m
    $148–231

  7. Bus to Quad City International Airport, fly, taxi

    1. Take the bus from Iowa City to Molinebus bus
    2. Fly from Quad City International Airport (MLI) to Fort Wayne International Airport (FWA)plane plane MLI - FWA
    3. Take the taxi from Fort Wayne International Airport (FWA) to Defiancetaxi taxi
    8h 5m
    $195–498

The Eastern Iowa Airport (CID) to Fort Wayne International Airport (FWA) flights

Calendar62Weekly Planes
Duration5h 2mAverage Duration
Ticket$103Cheapest Price
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Questions & Answers

Map of how to get from Iowa City to Defiance.ExpandLaunch map view
  • Distance: 445.5 mi
  • Duration: 8h 57m

What companies run services between Iowa City, IA, USA and Defiance, OH, USA?

You can take a bus from Iowa City to Defiance via Chicago, Chicago Union Station, and Bryan Amtrak Station in around 8h 57m.

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