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How to get fromIowa City to Defianceby bus, train, car, plane, taxi, or bus (Greyhound, Amtrak)

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There are 6 ways to get from Iowa City to Defiance by bus, train, car, plane, taxi, or bus (Greyhound, Amtrak)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus, train

    best
    1. Take the bus from Iowa City to Chicago Bus Stationbus bus Greyhound US0123S / ...
    2. Take the train from Chicago Union Station to Bryan Amtrak Stationtrain train Lake Shore Limited
    9h 37m
    $138–252

  2. Drive 401.4 mi

    cheapest
    1. Drive from Iowa City to Defiancecar car 401.4 mi
    7h 39m
    $74–106

  3. Bus to Quad City International Airport, fly, taxi

    1. Take the bus from Iowa City to Moline Center Stationbus bus
    2. Fly from Quad City International Airport (MLI) to Fort Wayne International Airport (FWA)plane plane MLI - FWA
    3. Take the taxi from Fort Wayne International Airport (FWA) to Defiancetaxi taxi
    7h 54m
    $195–498

  4. Bus

    1. Take the bus from Iowa City to Chicago Bus Stationbus bus Greyhound US0123S / ...
    2. Take the bus from Chicago Union Station to Bryan Amtrak Stationbus bus Amtrak Thruway Connecting Service
    9h 37m
    $148–227

  5. Bus to The Eastern Iowa Airport, fly, taxi

    1. Take the bus from Court St Transportation Center to GTC Bay 9bus bus
    2. Fly from The Eastern Iowa Airport (CID) to Fort Wayne International Airport (FWA)plane plane CID - FWA
    3. Take the taxi from Fort Wayne International Airport (FWA) to Defiancetaxi taxi
    7h 50m

  6. Bus to Chicago O'Hare International Airport, fly, taxi

    1. Take the bus from Iowa City to Chicago Bus Stationbus bus
    2. Fly from Chicago O'Hare International Airport (ORD) to Fort Wayne International Airport (FWA)plane plane ORD - FWA
    3. Take the taxi from Fort Wayne International Airport (FWA) to Defiancetaxi taxi
    9h 6m
    $210–517

Quad City International Airport (MLI) to Fort Wayne International Airport (FWA) flights

Calendar80Weekly Planes
Duration4h 52mAverage Duration
Ticket$46Cheapest Price
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Questions & Answers

Map of how to get from Iowa City to Defiance.ExpandLaunch map view
  • Distance: 422 mi
  • Duration: 9h 37m

What companies run services between Iowa City, IA, USA and Defiance, OH, USA?

You can take a bus from Iowa City to Defiance via Chicago Bus Station, Chicago Union Station, and Bryan Amtrak Station in around 9h 37m.

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