From Interlaken West train to Bern, train to Zürich HB, then train to Lugano. 5hrs 13min SFr 171. From Interlaken Ost train to Luzern then train to Lugano. 5hrs 22min SFr 116. From Interlaken, Kursaal bus to Spiez, train to Brig, bus to Malpensa Airport T1, bus to Malpensa Airport T2, then bus to Lugano. 7hrs 24min SFr 140. From Interlaken drive to Lugano. 2hrs 39min SFr 33.