There are 6 ways to get from Indianapolis to Tupelo by plane, car, bus (Greyhound, Amtrak, Flixbus), bus, or bus (Greyhound)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly to Golden Triangle Regional Airport, drive
best- Fly from Indianapolis (IND) to Golden Triangle Regional Airport (GTR)plane IND - GTR
- Drive from Golden Triangle Regional Airport (GTR) to Tupelocar
7h 7m$97–487Drive 463.6 mi
cheapest- Drive from Indianapolis to Tupelocar 463.6 mi
9h 34m$77–111Bus via Nashville
- Take the bus from Indianapolis Union Station to Nashville Bus Stationbus
- Take the bus from Nashville Bus Station to Memphis Bus Stationbus
- Take the bus from Memphis Bus Station to Tupelobus
12h 24m$109–156Fly to Tupelo Regional Airport
- Fly from Indianapolis (IND) to Tupelo Regional Airport (TUP)plane IND - TUP
7h 51m$81–440Fly to Memphis, bus
- Fly from Indianapolis (IND) to Memphis (MEM)plane IND - MEM
- Take the bus from Memphis Bus Station to Tupelobus
9h 22m$172–894Bus
- Take the bus from Indianapolis to Tornado Bus Co - West Memphisbus Indianapolis
- Take the bus from Memphis Bus Station to Tupelobus Greyhound US0610
15h 52m$165–202
Indianapolis (IND) to Golden Triangle Regional Airport (GTR) flights
Comparing Your Travel Options
The cheapest way to get from Indianapolis to Tupelo is to drive which costs $75 - $120 and takes 9h 34m.
The fastest way to get from Indianapolis to Tupelo is to fly and drive which takes 7h 7m and costs $95 - $490.
No, there is no direct bus from Indianapolis station to Tupelo. However, there are services departing from Indianapolis Union Station and arriving at Tupelo via Nashville Bus Station and Memphis Bus Station. The journey, including transfers, takes approximately 12h 24m.
The distance between Indianapolis and Tupelo is 530 miles. The road distance is 466.3 miles.
The best way to get from Indianapolis to Tupelo without a car is to bus via Nashville which takes 12h 24m and costs $100 - $160.
It takes approximately 7h 7m to get from Indianapolis to Tupelo, including transfers.
Indianapolis to Tupelo bus services, operated by Greyhound USA, depart from Indianapolis Union Station.
The best way to get from Indianapolis to Tupelo is to bus via Nashville which takes 12h 24m and costs $100 - $160. Alternatively, you can fly, which costs $80 - $440 and takes 7h 51m.
Indianapolis to Tupelo bus services, operated by Greyhound USA, arrive at Nashville Bus Station.
Tupelo is 1h behind Indianapolis. It is currently 10:29 AM in Indianapolis and 9:29 AM in Tupelo.
What companies run services between Indianapolis, IN, USA and Tupelo, MS, USA?
You can take a bus from Indianapolis Union Station to Tupelo via Nashville Bus Station, Memphis Bus Station, and Tupelo in around 12h 24m. Alternatively, American Airlines, Corporate Flight Management Inc, and three other airlines fly from Indianapolis (IND) to Tupelo Regional Airport (TUP) 4 times a day.
- Website
- delta.com
Flights from Indianapolis to Golden Triangle Regional Airport via Atlanta
- Ave. Duration
- 4h 45m
- When
- Every day
- Estimated price
- $85–470
Flights from Indianapolis to Memphis via Atlanta
- Ave. Duration
- 4h 31m
- When
- Every day
- Estimated price
- $180–1,000
Flights from Indianapolis to Memphis via Detroit
- Ave. Duration
- 5h 16m
- When
- Every day
- Estimated price
- $190–1,000
- Website
- contouraviation.com
Flights from Indianapolis to Tupelo Regional Airport via Dallas/Ft.Worth
- Ave. Duration
- 6h 48m
- When
- Every day
- Estimated price
- $120–600
Flights from Indianapolis to Tupelo Regional Airport via Nashville
- Ave. Duration
- 6h 50m
- When
- Monday to Saturday
- Estimated price
- $65–420
Flights from Indianapolis to Tupelo Regional Airport via Chicago Midway, Nashville
- Ave. Duration
- 6h 20m
- When
- Monday, Thursday, and Friday
- Estimated price
- $90–480
Flights from Indianapolis to Tupelo Regional Airport via Chicago O'Hare, Nashville
- Ave. Duration
- 6h 45m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $90–490
Flights from Indianapolis to Tupelo Regional Airport via Atlanta, Nashville
- Ave. Duration
- 7h 46m
- When
- Every day
- Estimated price
- $95–500
Flights from Indianapolis to Tupelo Regional Airport via Detroit, Nashville
- Ave. Duration
- 9h 17m
- When
- Sunday
- Estimated price
- $95–550
Flights from Indianapolis to Tupelo Regional Airport via Charlotte, Nashville
- Ave. Duration
- 9h 28m
- When
- Sunday
- Estimated price
- $100–550
- Website
- aa.com
Flights from Indianapolis to Golden Triangle Regional Airport via Dallas/Ft.Worth
- Ave. Duration
- 5h 28m
- When
- Every day
- Estimated price
- $120–600
Flights from Indianapolis to Memphis via Chicago O'Hare
- Ave. Duration
- 5h 11m
- When
- Every day
- Estimated price
- $170–950
Flights from Indianapolis to Memphis via Charlotte
- Ave. Duration
- 5h 2m
- When
- Every day
- Estimated price
- $200–1,100
- Website
- southwest.com
Flights from Indianapolis to Memphis via Nashville
- Ave. Duration
- 4h 20m
- When
- Monday, Thursday, Friday, Sunday, and Saturday
- Estimated price
- $140–850
Flights from Indianapolis to Memphis via Chicago Midway
- Ave. Duration
- 5h 55m
- When
- Monday, Thursday, Friday, and Sunday
- Estimated price
- $160–950
- Website
- united.com
Flights from Indianapolis to Memphis via Chicago O'Hare
- Ave. Duration
- 4h 52m
- When
- Every day
- Estimated price
- $170–950
Rome2Rio's guide to Greyhound USA
Contact Details
- Phone
- +1 214-849-8100
- ifsr@greyhound.com
- Website
- Greyhound
Bus from Indianapolis Union Station to Nashville Bus Station
- Ave. Duration
- 5h 20m
- Frequency
- 5 times a day
- Estimated price
- $50–80
- Website
- Greyhound
Bus from Nashville Bus Station to Memphis Bus Station
- Ave. Duration
- 3h 20m
- Frequency
- 4 times a day
- Estimated price
- $35–60
- Website
- Greyhound
Bus from Memphis Bus Station to Tupelo
- Ave. Duration
- 1h 40m
- Frequency
- Twice daily
- Estimated price
- $18–27
- Website
- Greyhound
Bus from Memphis Bus Station to Tupelo
- Ave. Duration
- 1h 40m
- Frequency
- Twice daily
- Estimated price
- $18–27
- Website
- Greyhound
Bus from Memphis Bus Station to Tupelo
- Ave. Duration
- 1h 40m
- Frequency
- Twice daily
- Estimated price
- $18–27
- Website
- Greyhound
Rome2Rio's guide to Amtrak Thruway
Contact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Bus from Indianapolis Union Station to Nashville Bus Station
- Ave. Duration
- 5h 20m
- Frequency
- Twice daily
- Estimated price
- $45–60
- Website
- Amtrak
- Adult
- $45–60
- Phone
- +1 (855) 626-8585
- Website
- Flixbus USA
Bus from Nashville Bus Station to Memphis Bus Station
- Ave. Duration
- 3h 30m
- Frequency
- 5 times a week
- Estimated price
- $30–50
- Schedules at
- Flixbus USA
- Phone
- +1 888 358 6762
- info@tornadobus.com
- Website
- Tornado Bus Company
Bus from Indianapolis to Tornado Bus Co - West Memphis
- Ave. Duration
- 10h 15m
- Frequency
- 3 times a week
- Estimated price
- $110–130
- Schedules at
- Tornado Bus Company
- Adult
- $110–130
Want to know more about travelling around United States
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Booking & Getting There
Yes, the driving distance between Indianapolis to Tupelo is 466 miles. It takes approximately 9h 34m to drive from Indianapolis to Tupelo.
Book your Indianapolis to Tupelo bus tickets online with Omio.
There are 35+ hotels available in Tupelo.












