There are 8 ways to get from Indianapolis to South Carolina by plane, bus, train or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly to Charlotte  •  3 h 46 min

  1. Fly from Indianapolis (IND) to Charlotte (CLT) IND - CLT

$227 - $392

Cheapest option

Bus Megabus  •  20 h 44 min

  1. Take the bus from Indianapolis, IN to Marta Civic Center Station - Nb
  2. Take the bus from Atlanta, GA to Florence 0983 / ...

$93 - $131

6 alternative options

Fly to Charleston  •  4 h 18 min

  1. Fly from Indianapolis (IND) to Charleston (CHS) IND - CHS

$164 - $605

Fly to Greenville/Spartanburg  •  5 h 14 min

  1. Fly from Indianapolis (IND) to Greenville/Spartanburg (GSP) IND - GSP

$202 - $947

Fly to Columbia  •  5 h 15 min

  1. Fly from Indianapolis (IND) to Columbia (CAE) IND - CAE

$236 - $1,132

Bus Greyhound USA  •  22 h 47 min

  1. Take the bus from Indianapolis, IN to Richmond, IN
  2. Take the bus from Richmond, IN to Columbus, OH
  3. Take the bus from Columbus, Oh to Columbia, Sc
  4. Take the bus from Columbia, SC to Florence, SC

$103 - $220

Train, Amtrak Thruway  •  24 h 2 min

  1. Take the train from Indianapolis Amtrak to Charlottesville Amtrak
  2. Take the Amtrak Thruway from Charlottesville, VA to Richmond - Staples, VA
  3. Take the train from Richmond Staples Mill Amtrak to Florence Amtrak

Drive  •  11 h 45 min

  1. Drive from Indianapolis to Florence 702.1 miles

$65 - $100

What companies run services between Indianapolis, IN, USA and South Carolina, USA?

American Airlines, Southwest Airlines and two other airlines fly from Indianapolis to Rock Hill hourly. Alternatively, you can take a bus from Indianapolis to Florence via Marta Civic Center Station - Nb, Peachtree St Ne @ Ivan Allen Jr Blvd, Peachtree St Sw @ Brotherton Transportation Mall, and Atlanta, GA in around 20 h 44 min.

Airlines
American Airlines
Website
aa.com
Flights from Indianapolis to Charlotte
Ave. Duration
1 h 42 min
When
Every day
Estimated price
$280 - $700
Flights from Indianapolis to Charleston via Charlotte
Ave. Duration
3 h 41 min
When
Every day
Estimated price
$220 - $1,100
Flights from Indianapolis to Greenville/Spartanburg via Charlotte
Ave. Duration
3 h 43 min
When
Every day
Estimated price
$180 - $900
Flights from Indianapolis to Greenville/Spartanburg via Reagan Washington
Ave. Duration
4 h 21 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$210 - $1,000
Flights from Indianapolis to Greenville/Spartanburg via Chicago O'Hare
Ave. Duration
4 h 18 min
When
Every day
Estimated price
$200 - $950
Flights from Indianapolis to Columbia via Charlotte
Ave. Duration
3 h 57 min
When
Every day
Estimated price
$220 - $1,100
Flights from Indianapolis to Columbia via Reagan Washington
Ave. Duration
4 h 18 min
When
Every day
Estimated price
$260 - $1,200
Flights from Indianapolis to Columbia via Philadelphia
Ave. Duration
5 h 49 min
When
Every day
Estimated price
$270 - $1,200
Flights from Indianapolis to Columbia via Dallas/Ft.Worth
Ave. Duration
6 h 46 min
When
Monday to Friday
Estimated price
$330 - $1,300
Delta
Website
delta.com
Flights from Indianapolis to Charleston via Atlanta
Ave. Duration
3 h 49 min
When
Every day
Estimated price
$220 - $1,100
Flights from Indianapolis to Greenville/Spartanburg via Atlanta
Ave. Duration
4 h 15 min
When
Every day
Estimated price
$170 - $900
Flights from Indianapolis to Greenville/Spartanburg via Detroit
Ave. Duration
4 h 19 min
When
Every day
Estimated price
$190 - $950
Flights from Indianapolis to Columbia via Atlanta
Ave. Duration
3 h 56 min
When
Every day
Estimated price
$210 - $1,100
United Airlines
Website
united.com
Flights from Indianapolis to Greenville/Spartanburg via Chicago O'Hare
Ave. Duration
4 h 26 min
When
Every day
Estimated price
$210 - $1,000
Flights from Indianapolis to Greenville/Spartanburg via Newark
Ave. Duration
5 h 13 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$250 - $1,100
Flights from Indianapolis to Columbia via Washington Dulles
Ave. Duration
3 h 57 min
When
Every day
Estimated price
$260 - $1,300
Flights from Indianapolis to Columbia via Chicago O'Hare
Ave. Duration
4 h 48 min
When
Every day
Estimated price
$260 - $1,200
Flights from Indianapolis to Columbia via Houston
Ave. Duration
7 h 12 min
When
Every day
Estimated price
$340 - $1,500
Southwest Airlines
Website
southwest.com
Flights from Indianapolis to Charleston via Chicago Midway
Ave. Duration
4 h
When
Every day
Estimated price
$280 - $1,200
Allegiant Air
Website
allegiantair.com
Flights from Indianapolis to Charleston
Ave. Duration
1 h 36 min
When
Monday and Friday
Estimated price
$160 - $600
Train operators
Amtrak
Phone
+1 1-800-872-7245
Website
amtrak.com
Train from Indianapolis Amtrak to Charlottesville Amtrak
Ave. Duration
15 h 11 min
Frequency
5 times a week
Estimated price
$85 - $250
Website
amtrak.com
Coach Seat
$85 - $130
Flexi Coach Seat
$150 - $230
Business Coach Seat
$170 - $250
Room
$360 - $550
Train from Richmond Staples Mill Amtrak to Florence Amtrak
Ave. Duration
5 h 21 min
Frequency
4 times a day
Estimated price
$50 - $140
Website
amtrak.com
Coach Seat
$50 - $80
Flexi Coach Seat
$90 - $140
Business Coach Seat
$95 - $140
Room
$240 - $340
Bus operators
Megabus
Phone
877-462-6342
Website
us.megabus.com
Bus from Indianapolis, IN to Marta Civic Center Station - Nb
Ave. Duration
10 h 47 min
Frequency
Twice daily
Estimated price
$50 - $65
Schedules at
us.megabus.com
South Eastern Stages
Phone
+1 877.836.7607 / 404.591.2750
Email
info@sestages.com
Website
southeasternstages.com
Bus from Atlanta, GA to Florence
Ave. Duration
8 h 30 min
Frequency
Every 4 hours
Estimated price
$40 - $65
Schedules at
southeasternstages.com
Bus from Columbia, SC to Florence, SC
Ave. Duration
1 h 38 min
Frequency
3 times a day
Estimated price
$19 - $27
Schedules at
southeasternstages.com
Barons Bus
Website
baronsbus.com
Bus from Indianapolis, IN to Richmond, IN
Ave. Duration
1 h 34 min
Frequency
Once daily
Estimated price
$13 - $25
Schedules at
baronsbus.com
Bus from Richmond, IN to Columbus, OH
Ave. Duration
2 h 10 min
Frequency
3 times a day
Estimated price
$15 - $28
Schedules at
baronsbus.com
Greyhound USA
Phone
+1 214-849-8100
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from Columbus, Oh to Columbia, Sc
Ave. Duration
15 h 5 min
Frequency
Hourly
Estimated price
$55 - $140
Website
greyhound.com
Economy
$55 - $95
Flexible
$100 - $140

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Questions & Answers

The distance between Indianapolis and South Carolina is 846 km. The road distance is 1123 km.

The cheapest way to get from Indianapolis to South Carolina is to drive which costs $65 - $100 and takes 11 h 45 min.

The quickest way to get from Indianapolis to South Carolina is to fly which takes 3 h 46 min and costs $220 - $400.

No, there is no direct bus from Indianapolis to South Carolina. However, there are services departing from Indianapolis, IN and arriving at Florence via Peachtree St Ne @ Ivan Allen Jr Blvd and Atlanta, GA. The journey, including transfers, takes approximately 20 h 44 min.

It takes approximately 3 h 46 min to get from Indianapolis to South Carolina, including transfers.