There are 8 ways to get from Indianapolis to South Carolina by plane, bus, train or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly to Charlotte  •  3 h 48 min

  1. Fly from Indianapolis (IND) to Charlotte (CLT) IND - CLT

$227 - $392

Cheapest option

Bus Megabus  •  17 h 37 min

  1. Take the bus from Delaware St & Market St Indianapolis to Marta Civic Center Station - Nb
  2. Take the bus from Atlanta, GA to Florence, SC Atlanta

$88 - $126

6 alternative options

Fly to Charleston  •  4 h 18 min

  1. Fly from Indianapolis (IND) to Charleston (CHS) IND - CHS

$164 - $605

Fly to Greenville/Spartanburg  •  5 h 16 min

  1. Fly from Indianapolis (IND) to Greenville/Spartanburg (GSP) IND - GSP

$202 - $947

Fly to Columbia  •  5 h 16 min

  1. Fly from Indianapolis (IND) to Columbia (CAE) IND - CAE

$236 - $1,132

Bus Greyhound USA  •  22 h 35 min

  1. Take the bus from Indianapolis, IN to Richmond, IN
  2. Take the bus from Richmond, IN to Columbus, OH
  3. Take the bus from Columbus, Oh to Columbia, Sc
  4. Take the bus from Columbia, SC to Florence, SC

$103 - $222

Train, bus  •  23 h 52 min

  1. Take the train from Indianapolis Amtrak to Charlottesville Amtrak
  2. Take the bus from Charlottesville Amtrak to Richmond Staples Mill Amtrak
  3. Take the train from Richmond Staples Mill Amtrak to Florence Amtrak

Drive  •  11 h 45 min

  1. Drive from Indianapolis to Florence 702.1 miles

$65 - $100

Questions & Answers

The cheapest way to get from Indianapolis to South Carolina is to drive which costs $65 - $100 and takes 11 h 45 min.

More details

The quickest way to get from Indianapolis to South Carolina is to fly which costs $220 - $400 and takes 3 h 48 min.

More details

No, there is no direct bus from Indianapolis to South Carolina. However, there are services departing from Delaware St & Market St Indianapolis and arriving at Florence, SC via Peachtree St Ne @ Ivan Allen Jr Blvd and Atlanta, GA. The journey, including transfers, takes approximately 17 h 37 min.

More details

The distance between Indianapolis and South Carolina is 529 miles. The road distance is 702.1 miles.

Get driving directions

The best way to get from Indianapolis to South Carolina without a car is to bus which takes 17 h 37 min and costs $85 - $130.

More details

It takes approximately 3 h 48 min to get from Indianapolis to South Carolina, including transfers.

More details

Indianapolis to South Carolina bus services, operated by Megabus, depart from Delaware St & Market St Indianapolis station.

More details

The best way to get from Indianapolis to South Carolina is to fly which takes 3 h 48 min and costs $220 - $400. Alternatively, you can bus, which costs $85 - $130 and takes 17 h 37 min.

Mode details

The quickest flight from Indianapolis Airport to Charlotte Airport is the direct flight which takes 1 h 36 min.

Search flights

Indianapolis to South Carolina bus services, operated by South Eastern Stages, arrive at Florence, SC station.

More details

Map of how to get from Indianapolis to South Carolina.
Launch map view
  • Distance: 529 miles
  • Duration: 3 h 48 min

What companies run services between Indianapolis, IN, USA and South Carolina, USA?

American Airlines, Southwest Airlines and two other airlines fly from Indianapolis to Rock Hill hourly. Alternatively, you can take a bus from Indianapolis to Florence via Marta Civic Center Station - Nb, Peachtree St Ne @ Ivan Allen Jr Blvd, Peachtree St Sw @ Brotherton Transportation Mall, and Atlanta, GA in around 17 h 37 min.

Airlines
American Airlines
Website
aa.com
Flights from Indianapolis to Charlotte
Ave. Duration
1 h 43 min
When
Every day
Estimated price
$280 - $700
Flights from Indianapolis to Charleston via Charlotte
Ave. Duration
3 h 57 min
When
Every day
Estimated price
$220 - $1,100
Flights from Indianapolis to Greenville/Spartanburg via Charlotte
Ave. Duration
3 h 54 min
When
Every day
Estimated price
$180 - $900
Flights from Indianapolis to Greenville/Spartanburg via Reagan Washington
Ave. Duration
4 h 16 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$210 - $1,000
Flights from Indianapolis to Greenville/Spartanburg via Chicago O'Hare
Ave. Duration
4 h 28 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$200 - $950
Flights from Indianapolis to Greenville/Spartanburg via Philadelphia
Ave. Duration
4 h 36 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$230 - $1,000
Flights from Indianapolis to Columbia via Charlotte
Ave. Duration
3 h 57 min
When
Every day
Estimated price
$220 - $1,100
Flights from Indianapolis to Columbia via Reagan Washington
Ave. Duration
4 h 22 min
When
Every day
Estimated price
$260 - $1,200
Flights from Indianapolis to Columbia via Philadelphia
Ave. Duration
4 h 55 min
When
Every day
Estimated price
$270 - $1,200
Flights from Indianapolis to Columbia via Dallas/Ft.Worth
Ave. Duration
6 h 2 min
When
Every day
Estimated price
$330 - $1,300
Delta
Website
delta.com
Flights from Indianapolis to Charlotte via Atlanta
Ave. Duration
3 h 54 min
When
Every day
Estimated price
$250 - $650
Flights from Indianapolis to Charleston via Atlanta
Ave. Duration
3 h 45 min
When
Every day
Estimated price
$220 - $1,100
Flights from Indianapolis to Greenville/Spartanburg via Atlanta
Ave. Duration
3 h 52 min
When
Every day
Estimated price
$170 - $900
Flights from Indianapolis to Greenville/Spartanburg via Detroit
Ave. Duration
4 h 6 min
When
Every day
Estimated price
$190 - $950
Flights from Indianapolis to Columbia via Atlanta
Ave. Duration
4 h 9 min
When
Every day
Estimated price
$210 - $1,100
United Airlines
Website
united.com
Flights from Indianapolis to Charleston via Washington Dulles
Ave. Duration
4 h 9 min
When
Every day
Estimated price
$270 - $1,300
Flights from Indianapolis to Greenville/Spartanburg via Washington Dulles
Ave. Duration
4 h 6 min
When
Every day
Estimated price
$220 - $1,100
Flights from Indianapolis to Greenville/Spartanburg via Chicago O'Hare
Ave. Duration
4 h 22 min
When
Every day
Estimated price
$210 - $1,000
Flights from Indianapolis to Columbia via Chicago O'Hare
Ave. Duration
4 h 5 min
When
Every day
Estimated price
$260 - $1,200
Flights from Indianapolis to Columbia via Washington Dulles
Ave. Duration
4 h 8 min
When
Every day
Estimated price
$260 - $1,300
Flights from Indianapolis to Columbia via Houston
Ave. Duration
6 h 19 min
When
Every day
Estimated price
$340 - $1,500
Southwest Airlines
Website
southwest.com
Flights from Indianapolis to Charlotte via Chicago Midway
Ave. Duration
3 h 40 min
When
Sunday
Estimated price
$320 - $650
Flights from Indianapolis to Charlotte via Baltimore
Ave. Duration
3 h 50 min
When
Sunday
Estimated price
$320 - $650
Flights from Indianapolis to Greenville/Spartanburg via Atlanta
Ave. Duration
3 h 30 min
When
Monday to Friday
Estimated price
$200 - $900
Allegiant Air
Website
allegiantair.com
Flights from Indianapolis to Charleston
Ave. Duration
1 h 36 min
When
Monday and Friday
Estimated price
$160 - $600
Train operators
Amtrak

Amtrak is a rail service that connects the US and three Canadian provinces. Covering 21,000 route miles (34,000km) Amtrak operates more than 300 trains daily. These medium and long distance intercity services operate at speeds of up to 240km/h, to more than 500 destinations. Founded in 1971, it is based in Washington, D.C. and offers four classes of travel: First Class, Sleeper, Business and Coach. Ticket fares are divided into five subclasses: Saver, Value, Flexible, Business and Premium. Amtrak trains are known for their wide seats, plug-in power, big windows and storage capabilities.

Rome2rio's guide to Amtrak
Contact Details
Phone
+1 1-800-872-7245
Website
amtrak.com
Train from Indianapolis Amtrak to Charlottesville Amtrak
Ave. Duration
15 h 11 min
Frequency
4 times a week
Estimated price
$85 - $250
Website
amtrak.com
Coach Seat
$85 - $130
Flexi Coach Seat
$150 - $230
Business Coach Seat
$170 - $250
Room
$360 - $550
Train from Richmond Staples Mill Amtrak to Florence Amtrak
Ave. Duration
5 h 21 min
Frequency
Twice daily
Estimated price
$50 - $140
Website
amtrak.com
Coach Seat
$50 - $80
Flexi Coach Seat
$90 - $140
Business Coach Seat
$95 - $140
Room
$240 - $340
Bus operators
Megabus
Phone
877-462-6342
Website
us.megabus.com
Bus from Delaware St & Market St Indianapolis to Marta Civic Center Station - Nb
Ave. Duration
10 h 40 min
Frequency
Twice daily
Estimated price
$50 - $65
Book at
megabus.com
South Eastern Stages
Phone
+1 877.836.7607 / 404.591.2750
Email
info@sestages.com
Website
southeasternstages.com
Bus from Atlanta, GA to Florence, SC
Ave. Duration
5 h 30 min
Frequency
Once daily
Estimated price
$35 - $60
Schedules at
southeasternstages.com
Bus from Columbia, SC to Florence, SC
Ave. Duration
1 h 20 min
Frequency
3 times a day
Estimated price
$19 - $29
Schedules at
southeasternstages.com
Barons Bus
Phone
+1 888-378-3823
Website
baronsbus.com
Bus from Indianapolis, IN to Richmond, IN
Ave. Duration
1 h 50 min
Frequency
Once daily
Estimated price
$13 - $25
Book at
baronsbus.com
Bus from Richmond, IN to Columbus, OH
Ave. Duration
2 h
Frequency
Once daily
Estimated price
$15 - $28
Book at
baronsbus.com
Greyhound USA

Greyhound is a leading bus company based in Dallas, Texas, serving over 3800 destinations across North America, Mexico and Canada. Greyhound carries around 18 million passengers a year who travel 5.4 billion miles (8.6 billion km) a year on their fleet of around 1700 vehicles. For travel flexibility, you can board or get off a Greyhound bus at official Greyhound stations, partner stations and curbside stops. There are around 230 Greyhound stations across the US where you can both catch your bus and buy tickets, that are also available on the official website and via the mobile app.

Rome2rio's guide to Greyhound USA
Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from Columbus, Oh to Columbia, Sc
Ave. Duration
15 h 5 min
Frequency
Hourly
Estimated price
$55 - $140
Website
greyhound.com
Economy
$55 - $95
Flexible
$100 - $140
Amtrak

Amtrak is a rail service that connects the US and three Canadian provinces. Covering 21,000 route miles (34,000km) Amtrak operates more than 300 trains daily. These medium and long distance intercity services operate at speeds of up to 240km/h, to more than 500 destinations. Founded in 1971, it is based in Washington, D.C. and offers four classes of travel: First Class, Sleeper, Business and Coach. Ticket fares are divided into five subclasses: Saver, Value, Flexible, Business and Premium. Amtrak trains are known for their wide seats, plug-in power, big windows and storage capabilities.

Rome2rio's guide to Amtrak
Contact Details
Phone
+1 1-800-872-7245
Website
amtrak.com
Bus from Charlottesville Amtrak to Richmond Staples Mill Amtrak
Ave. Duration
1 h 20 min
Frequency
Twice daily
Website
amtrak.com

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