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There are 8 ways to get from Indianapolis to Mayo Clinic by plane, shuttle, bus, train or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly Indianapolis to Rochester  •  6h 15m

  1. Fly from Indianapolis (IND) to Rochester (RST) IND - RST

$189 - $963

Cheapest option

Bus  •  13h 33m

  1. Take the bus from Delaware St & Market St Indianapolis to Chicago
  2. Take the bus from Chicago to Milwaukee, WI
  3. Take the bus from Milwaukee to Rochester, MN 966

$84 - $130

6 alternative options

Fly Indianapolis to Minneapolis, shuttle  •  5h 39m

  1. Fly from Indianapolis (IND) to Minneapolis (MSP) IND - MSP
  2. Take a shuttle bus from Terminal 2 MSP to 2nd Street Rochester

$174 - $420

Fly Indianapolis to La Crosse, bus  •  7h 55m

  1. Fly from Indianapolis (IND) to La Crosse (LSE) IND - LSE
  2. Take the bus from La Crosse, WI to Rochester, MN

$227 - $1,053

Bus to Chicago O'Hare, fly to Rochester  •  7h 43m

  1. Take the bus from Delaware St & Market St Indianapolis to Chicago
  2. Fly from Chicago O'Hare (ORD) to Rochester (RST) ORD - RST

$178 - $745

Train, bus  •  13h 30m

  1. Take the train from Indianapolis Amtrak Station to Chicago Union Station
  2. Take the train from Chicago Union Station to Winona Amtrak Station
  3. Take the bus from Winona Amtrak Station to Rochester, MN

$121 - $298

Bus via Chicago, IL - O'Hare International Airport  •  14h 22m

  1. Take the bus from Indianapolis, IN to Chicago, IL
  2. Take the bus from Chicago, IL - O'Hare International Airport to Milwaukee, WI - Amtrak
  3. Take the bus from Milwaukee to Rochester, MN 966

$114 - $175

Drive  •  8h 51m

  1. Drive from Indianapolis to Mayo Clinic 535 miles

$50 - $80

Questions & Answers

The cheapest way to get from Indianapolis to Mayo Clinic is to drive which costs $50 - $80 and takes 8h 51m.

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The quickest way to get from Indianapolis to Mayo Clinic is to fly and shuttle which costs $170 - $420 and takes 5h 39m.

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No, there is no direct bus from Indianapolis to Mayo Clinic. However, there are services departing from Delaware St & Market St Indianapolis and arriving at Rochester, MN via Chicago and Milwaukee. The journey, including transfers, takes approximately 13h 33m.

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The distance between Indianapolis and Mayo Clinic is 440 miles. The road distance is 535 miles.

Get driving directions

The best way to get from Indianapolis to Mayo Clinic without a car is to train and bus which takes 13h 30m and costs $120 - $300.

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It takes approximately 6h 15m to get from Indianapolis to Mayo Clinic, including transfers.

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Indianapolis to Mayo Clinic bus services, operated by Megabus, depart from Delaware St & Market St Indianapolis station.

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The best way to get from Indianapolis to Mayo Clinic is to fly which takes 6h 15m and costs $180 - $1,000. Alternatively, you can bus, which costs $80 - $130 and takes 13h 33m.

Mode details

There is no direct flight from Indianapolis Airport to Rochester Airport. The quickest flight takes 3h 26m and has one stopover.

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Indianapolis to Mayo Clinic bus services, operated by Jefferson Lines, arrive at Rochester, MN station.

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Map of how to get from Indianapolis to Mayo Clinic.
Launch map view
  • Distance: 440.1 miles
  • Duration: 6h 15m

What companies run services between Indianapolis, IN, USA and Mayo Clinic, MN, USA?

American Airlines, United Airlines and two other airlines fly from Indianapolis to Mayo Clinic hourly. Alternatively, you can take a bus from Indianapolis to Mayo Clinic via Chicago, Milwaukee, WI, Milwaukee, and Rochester, MN in around 13h 33m.

Airlines
Delta
Website
delta.com
Flights from Indianapolis to Rochester via Minneapolis
Ave. Duration
5h 52m
When
Every day
Estimated price
$180 - $950
Flights from Indianapolis to Rochester via Atlanta
Ave. Duration
6h 31m
When
Every day
Estimated price
$230 - $1,100
Flights from Indianapolis to Minneapolis
Ave. Duration
2h
When
Every day
Estimated price
$280 - $850
Flights from Indianapolis to La Crosse via Detroit
Ave. Duration
3h 55m
When
Saturday
Estimated price
$200 - $1,100
Flights from Indianapolis to La Crosse via Minneapolis
Ave. Duration
6h 28m
When
Every day
Estimated price
$200 - $1,100
Flights from Indianapolis to La Crosse via Detroit, Minneapolis
Ave. Duration
6h 30m
When
Sunday
Estimated price
$220 - $1,100
Flights from Indianapolis to La Crosse via Atlanta, Detroit
Ave. Duration
7h 19m
When
Saturday
Estimated price
$270 - $1,200
American Airlines
Website
aa.com
Flights from Indianapolis to Rochester via Chicago O'Hare
Ave. Duration
4h 31m
When
Every day
Estimated price
$180 - $950
Flights from Indianapolis to Rochester via Charlotte, Chicago O'Hare
Ave. Duration
6h 57m
When
Saturday
Estimated price
$250 - $1,100
Flights from Indianapolis to Minneapolis via Chicago O'Hare
Ave. Duration
3h 43m
When
Every day
Estimated price
$280 - $700
Flights from Indianapolis to La Crosse via Chicago O'Hare
Ave. Duration
4h 26m
When
Every day
Estimated price
$190 - $1,000
Flights from Indianapolis to La Crosse via Reagan Washington, Chicago O'Hare
Ave. Duration
7h 22m
When
Monday, Wednesday, Thursday, Friday and Sunday
Estimated price
$280 - $1,200
Flights from Chicago O'Hare to Rochester
Ave. Duration
1h 14m
When
Every day
Estimated price
$260 - $750
United Airlines
Website
united.com
Flights from Indianapolis to Rochester via Chicago O'Hare
Ave. Duration
4h 5m
When
Every day
Estimated price
$200 - $1,000
Flights from Indianapolis to Rochester via Washington Dulles, Chicago O'Hare
Ave. Duration
7h 7m
When
Every day
Estimated price
$260 - $1,200
Flights from Indianapolis to Minneapolis via Chicago O'Hare
Ave. Duration
3h 48m
When
Every day
Estimated price
$290 - $800
Flights from Chicago O'Hare to Rochester
Ave. Duration
1h 21m
When
Every day
Estimated price
$150 - $750
Train operators
Amtrak

Amtrak is a rail service that connects the US and three Canadian provinces. Covering 21,000 route miles (34,000km) Amtrak operates more than 300 trains daily. These medium and long distance intercity services operate at speeds of up to 240km/h, to more than 500 destinations. Founded in 1971, it is based in Washington, D.C. and offers four classes of travel: First Class, Sleeper, Business and Coach. Ticket fares are divided into five subclasses: Saver, Value, Flexible, Business and Premium. Amtrak trains are known for their wide seats, plug-in power, big windows and storage capabilities.

Rome2rio's guide to Amtrak
Contact Details
Phone
+1 215-856-7924
Website
amtrak.com
Train from Indianapolis Amtrak Station to Chicago Union Station
Ave. Duration
5h
Frequency
Once daily
Estimated price
$40 - $100
Website
amtrak.com
Coach Seat
$40 - $60
Flexi Coach Seat
$70 - $110
Business Coach Seat
$70 - $100
Room
$200 - $280
Train from Chicago Union Station to Winona Amtrak Station
Ave. Duration
5h 26m
Frequency
3 times a day
Estimated price
$50 - $140
Website
amtrak.com
Coach Seat
$50 - $80
Flexi Coach Seat
$95 - $140
Business Coach Seat
$95 - $140
Room
$240 - $340
Bus operators
Groome Transportation
Phone
(800) 280-9270
Website
groometransportation.com
Shuttle from Terminal 2 MSP to 2nd Street Rochester
Ave. Duration
1h 25m
Frequency
Hourly
Estimated price
$30 - $45
Schedules at
groometransportation.com
Bus from Winona Amtrak Station to Rochester, MN
Ave. Duration
1h 20m
Frequency
Every 3 hours
Estimated price
$25 - $45
Schedules at
groometransportation.com
Jefferson Lines
Phone
800-451-5333
Email
info@jeffersonlines.com
Website
jeffersonlines.com
Bus from La Crosse, WI to Rochester, MN
Ave. Duration
1h 35m
Frequency
Once daily
Estimated price
$22 - $35
Book at
jeffersonlines.com
Bus from Milwaukee to Rochester, MN
Ave. Duration
6h 10m
Frequency
Once daily
Estimated price
$55 - $80
Book at
jeffersonlines.com
Megabus
Phone
877-462-6342
Website
us.megabus.com
Bus from Delaware St & Market St Indianapolis to Chicago
Ave. Duration
3h 25m
Frequency
Twice daily
Estimated price
$18 - $29
Book at
megabus.com
Bus from Chicago to Milwaukee, WI
Ave. Duration
1h 50m
Frequency
4 times a day
Estimated price
$10 - $21
Book at
megabus.com
Amtrak Thruway

Amtrak is a rail service that connects the US and three Canadian provinces. Covering 21,000 route miles (34,000km) Amtrak operates more than 300 trains daily. These medium and long distance intercity services operate at speeds of up to 240km/h, to more than 500 destinations. Founded in 1971, it is based in Washington, D.C. and offers four classes of travel: First Class, Sleeper, Business and Coach. Ticket fares are divided into five subclasses: Saver, Value, Flexible, Business and Premium. Amtrak trains are known for their wide seats, plug-in power, big windows and storage capabilities.

Rome2rio's guide to Amtrak Thruway
Contact Details
Phone
+1 215-856-7924
Website
amtrak.com
Bus from Winona Amtrak Station to Rochester, MN
Ave. Duration
1h 20m
Frequency
Every 4 hours
Estimated price
$18 - $26
Website
amtrak.com
Coach USA
Phone
201-225-7500
Website
coachusa.com
Bus from Chicago, IL - O'Hare International Airport to Milwaukee, WI - Amtrak
Ave. Duration
1h 45m
Frequency
Hourly
Estimated price
$21 - $35
Schedules at
web.coachusa.com
Book at
coachusaairportexpress.com

Want to know more about travelling around United States

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More Questions & Answers

Yes, the driving distance between Indianapolis to Mayo Clinic is 535 miles. It takes approximately 8h 51m to drive from Indianapolis to Mayo Clinic.

Get driving directions

United Airlines, American Airlines and Delta offer flights from Indianapolis Airport to Rochester Airport.

Search flights

There are 57+ hotels available in Mayo Clinic. Prices start at $72 USD per night.

More details

The best way to get from Indianapolis to Indianapolis Airport is to line 8 bus which takes 39m and costs $2.

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