There are 7 ways to get from Indianapolis to Mayo Clinic by plane, bus, train or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly to Rochester  •  6 h 12 min

  1. Fly from Indianapolis (IND) to Rochester (RST) IND - RST

$189 - $963

Cheapest option

Bus  •  13 h 28 min

  1. Take the bus from Delaware St & Market St Indianapolis to Chicago
  2. Take the bus from Chicago, Il to Milwaukee, Wi
  3. Take the bus from Milwaukee to Rochester, MN 966

$89 - $144

5 alternative options

Fly to Minneapolis, bus  •  5 h 50 min

  1. Fly from Indianapolis (IND) to Minneapolis (MSP) IND - MSP
  2. Take the bus from Minneapolis-St Paul Airport, MN to Rochester, MN

$164 - $407

Fly to La Crosse, bus  •  8 h 25 min

  1. Fly from Indianapolis (IND) to La Crosse (LSE) IND - LSE
  2. Take the bus from La Crosse, WI to Rochester, MN

$236 - $1,046

Train, bus  •  13 h 52 min

  1. Take the train from Indianapolis Amtrak to Chicago Union Station
  2. Take the train from Chicago Union Station to Winona Amtrak
  3. Take the bus from Winona, MN to Rochester, MN

$126 - $273

Bus via Indianapolis, IN  •  13 h 57 min

  1. Take the bus from Indianapolis, IN to Chicago, IL
  2. Take the bus from Chicago, Il to Milwaukee, Wi
  3. Take the bus from Milwaukee to Rochester, MN 966

$108 - $173

Drive  •  8 h 51 min

  1. Drive from Indianapolis to Mayo Clinic 535 miles

$50 - $80

Questions & Answers

No, there is no direct bus from Indianapolis to Mayo Clinic. However, there are services departing from Delaware St & Market St Indianapolis and arriving at Rochester, MN via Chicago, Il and Milwaukee. The journey, including transfers, takes approximately 13 h 28 min.

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The distance between Indianapolis and Mayo Clinic is 440 miles. The road distance is 535 miles.

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The best way to get from Indianapolis to Mayo Clinic without a car is to bus which takes 13 h 28 min and costs .

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It takes approximately 6 h 12 min to get from Indianapolis to Mayo Clinic, including transfers.

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Indianapolis to Mayo Clinic bus services, operated by Megabus, depart from Delaware St & Market St Indianapolis station.

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The best way to get from Indianapolis to Mayo Clinic is to fly which takes 6 h 12 min and costs . Alternatively, you can bus, which costs and takes 13 h 28 min.

Mode details

There is no direct flight from Indianapolis Airport to Rochester Airport. The quickest flight takes 3 h 23 min and has one stopover.

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Indianapolis to Mayo Clinic bus services, operated by Jefferson Lines, arrive at Rochester, MN station.

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Yes, the driving distance between Indianapolis to Mayo Clinic is 535 miles. It takes approximately 8 h 51 min to drive from Indianapolis to Mayo Clinic.

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United Airlines, American Airlines and Delta offer flights from Indianapolis Airport to Rochester Airport.

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Map of how to get from Indianapolis to Mayo Clinic.
Launch map view
  • Distance: 440.1 miles
  • Duration: 6 h 12 min

What companies run services between Indianapolis, IN, USA and Mayo Clinic, MN, USA?

United Airlines, American Airlines and two other airlines fly from Indianapolis to Mayo Clinic hourly. Alternatively, you can take a bus from Indianapolis to Mayo Clinic via Chicago, Chicago, Il, Milwaukee, Wi, Milwaukee, and Rochester, MN in around 13 h 28 min.

Airlines
Delta
Website
delta.com
Flights from Indianapolis to Rochester via Minneapolis
Ave. Duration
5 h 20 min
When
Every day
Estimated price
$180 - $950
Flights from Indianapolis to Rochester via Atlanta
Ave. Duration
5 h 56 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$230 - $1,100
Flights from Indianapolis to Rochester via Detroit, Minneapolis
Ave. Duration
5 h 48 min
When
Every day
Estimated price
$200 - $1,000
Flights from Indianapolis to Minneapolis
Ave. Duration
1 h 47 min
When
Every day
Estimated price
$280 - $850
Flights from Indianapolis to La Crosse via Minneapolis
Ave. Duration
4 h 55 min
When
Every day
Estimated price
$200 - $1,100
Flights from Indianapolis to La Crosse via Detroit, Minneapolis
Ave. Duration
6 h 17 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$220 - $1,100
American Airlines
Website
aa.com
Flights from Indianapolis to Rochester via Chicago O'Hare
Ave. Duration
4 h 8 min
When
Every day
Estimated price
$180 - $950
Flights from Indianapolis to Minneapolis via Chicago O'Hare
Ave. Duration
3 h 35 min
When
Every day
Estimated price
$280 - $700
Flights from Indianapolis to La Crosse via Chicago O'Hare
Ave. Duration
4 h 28 min
When
Every day
Estimated price
$190 - $1,000
Flights from Indianapolis to La Crosse via Reagan Washington, Chicago O'Hare
Ave. Duration
7 h 32 min
When
Every day
Estimated price
$280 - $1,200
United Airlines
Website
united.com
Flights from Indianapolis to Rochester via Chicago O'Hare
Ave. Duration
4 h 4 min
When
Every day
Estimated price
$200 - $1,000
Flights from Indianapolis to Minneapolis via Chicago O'Hare
Ave. Duration
3 h 41 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$290 - $800
Train operators
Amtrak

Amtrak is a rail service that connects the US and three Canadian provinces. Covering 21,000 route miles (34,000km) Amtrak operates more than 300 trains daily. These medium and long distance intercity services operate at speeds of up to 240km/h, to more than 500 destinations. Founded in 1971, it is based in Washington, D.C. and offers four classes of travel: First Class, Sleeper, Business and Coach. Ticket fares are divided into five subclasses: Saver, Value, Flexible, Business and Premium. Amtrak trains are known for their wide seats, plug-in power, big windows and storage capabilities.

Rome2rio's guide to Amtrak
Contact Details
Phone
+1 1-800-872-7245
Website
amtrak.com
Train from Indianapolis Amtrak to Chicago Union Station
Ave. Duration
5 h
Frequency
Once daily
Estimated price
$40 - $100
Website
amtrak.com
Coach Seat
$40 - $60
Flexi Coach Seat
$70 - $110
Business Coach Seat
$70 - $100
Room
$200 - $280
Train from Chicago Union Station to Winona Amtrak
Ave. Duration
5 h 26 min
Frequency
3 times a day
Estimated price
$50 - $140
Website
amtrak.com
Coach Seat
$50 - $80
Flexi Coach Seat
$95 - $140
Business Coach Seat
$95 - $140
Room
$240 - $340
Bus operators
Jefferson Lines
Phone
800-451-5333
Email
info@jeffersonlines.com
Website
jeffersonlines.com
Bus from Minneapolis-St Paul Airport, MN to Rochester, MN
Ave. Duration
1 h 20 min
Frequency
Every 3 hours
Estimated price
$22 - $35
Book at
jeffersonlines.com
Bus from Milwaukee to Rochester, MN
Ave. Duration
6 h 10 min
Frequency
Every 3 hours
Estimated price
$55 - $80
Book at
jeffersonlines.com
Go Carefree Shuttle
Website
gocarefreeshuttle.com
Bus from La Crosse, WI to Rochester, MN
Ave. Duration
1 h 50 min
Frequency
Every 4 hours
Estimated price
$44
Schedules at
gocarefreeshuttle.com
Bus from Winona, MN to Rochester, MN
Ave. Duration
1 h 20 min
Frequency
Every 4 hours
Estimated price
$35
Schedules at
gocarefreeshuttle.com
Megabus
Greyhound USA

Greyhound is a leading bus company based in Dallas, Texas, serving over 3800 destinations across North America, Mexico and Canada. Greyhound carries around 18 million passengers a year who travel 5.4 billion miles (8.6 billion km) a year on their fleet of around 1700 vehicles. For travel flexibility, you can board or get off a Greyhound bus at official Greyhound stations, partner stations and curbside stops. There are around 230 Greyhound stations across the US where you can both catch your bus and buy tickets, that are also available on the official website and via the mobile app.

Rome2rio's guide to Greyhound USA
Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from Chicago, Il to Milwaukee, Wi
Ave. Duration
2 h 20 min
Frequency
Every 20 minutes
Estimated price
$15 - $35
Website
greyhound.com
Economy
$15 - $23
Flexible
$28 - $35

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More Questions & Answers

There are 56+ hotels available in Mayo Clinic. Prices start at $67 USD per night.

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The best way to get from Indianapolis to Indianapolis Airport is to line 8 bus which takes 39 min and costs .

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