There are 6 ways to get from Indianapolis to Great Smoky Mountains National Park by plane, car, bus or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly to Knoxville, drive  •  6 h 32 min

  1. Fly from Indianapolis (IND) to Knoxville (TYS) IND - TYS
  2. Drive from Knoxville to Great Smoky Mountains National Park

$207 - $1,111

Cheapest option

Bus, drive  •  21 h 32 min

  1. Take the bus from Indianapolis, IN to Richmond, IN
  2. Take the bus from Richmond, IN to Columbus, OH
  3. Take the bus from Columbus, Oh to Winston Salem, Nc
  4. Take the bus from Winston Salem, Nc to Asheville, Nc
  5. Drive from Asheville, Nc to Great Smoky Mountains National Park

$96 - $224

4 alternative options

Fly to Asheville, drive  •  6 h 54 min

  1. Fly from Indianapolis (IND) to Asheville (AVL) IND - AVL
  2. Drive from Asheville to Great Smoky Mountains National Park

$229 - $1,014

Bus, drive via Government Square Area B  •  21 h 43 min

  1. Take the bus from Indianapolis, IN to University of Cincinnati
  2. Take the bus from Cincinnati, Oh to Columbus, Oh
  3. Take the bus from Columbus, Oh to Winston Salem, Nc
  4. Take the bus from Winston Salem, Nc to Asheville, Nc
  5. Drive from Asheville, Nc to Great Smoky Mountains National Park

$96 - $236

Train, bus, drive  •  26 h 16 min

  1. Take the train from Indianapolis Amtrak to Charlottesville Amtrak
  2. Take the train from Charlottesville Amtrak to Greensboro Galyon Transportation Center
  3. Take the bus from Greensboro, Nc to Winston Salem, Nc
  4. Take the bus from Winston Salem, Nc to Asheville, Nc
  5. Drive from Asheville, Nc to Great Smoky Mountains National Park

$160 - $415

Drive  •  6 h 49 min

  1. Drive from Indianapolis to Great Smoky Mountains National Park 420.5 miles

$40 - $60

Questions & Answers

The distance between Indianapolis and Great Smoky Mountains National Park is 324 miles. The road distance is 420.5 miles.

Get driving directions

It takes approximately 6 h 32 min to get from Indianapolis to Great Smoky Mountains National Park, including transfers.

More details

There is no direct flight from Indianapolis Airport to Knoxville Airport. The quickest flight takes 3 h 16 min and has one stopover.

Search flights

Yes, the driving distance between Indianapolis to Great Smoky Mountains National Park is 420 miles. It takes approximately 6 h 49 min to drive from Indianapolis to Great Smoky Mountains National Park.

Get driving directions

American Airlines, United Airlines and Delta offer flights from Indianapolis Airport to Knoxville Airport.

Search flights

There are 1719+ hotels available in Great Smoky Mountains National Park. Prices start at $67 USD per night.

More details

The best way to get from Indianapolis to Indianapolis Airport is to line 8 bus which takes 39 min and costs .

More details

Map of how to get from Indianapolis to Great Smoky Mountains National Park.
Launch map view
  • Distance: 324.2 miles
  • Duration: 6 h 32 min

What companies run services between Indianapolis, IN, USA and Great Smoky Mountains National Park, TN, USA?

There is no direct connection from Indianapolis to Great Smoky Mountains National Park. However, you can take the line 8 bus to Indianapolis Airport, take the walk to Indianapolis airport, fly to Knoxville, then take the drive to Great Smoky Mountains National Park. Alternatively, you can take the line 8 bus to Indianapolis Airport, take the walk to Indianapolis airport, fly to Asheville, then take the drive to Great Smoky Mountains National Park.

Airlines
Delta
Website
delta.com
Flights from Indianapolis to Knoxville via Atlanta
Ave. Duration
3 h 42 min
When
Every day
Estimated price
$200 - $1,100
Flights from Indianapolis to Knoxville via Detroit
Ave. Duration
3 h 55 min
When
Every day
Estimated price
$210 - $1,100
Flights from Indianapolis to Asheville via Atlanta
Ave. Duration
4 h 2 min
When
Every day
Estimated price
$200 - $1,100
United Airlines
Website
united.com
Flights from Indianapolis to Knoxville via Chicago O'Hare
Ave. Duration
4 h 3 min
When
Every day
Estimated price
$230 - $1,100
Flights from Indianapolis to Knoxville via Washington Dulles
Ave. Duration
4 h 9 min
When
Every day
Estimated price
$250 - $1,200
Flights from Indianapolis to Asheville via Chicago O'Hare
Ave. Duration
5 h 10 min
When
Every day
Estimated price
$240 - $1,200
American Airlines
Website
aa.com
Flights from Indianapolis to Knoxville via Charlotte
Ave. Duration
3 h 58 min
When
Every day
Estimated price
$210 - $1,100
Flights from Indianapolis to Knoxville via Chicago O'Hare
Ave. Duration
4 h 9 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$220 - $1,100
Flights from Indianapolis to Knoxville via Reagan Washington
Ave. Duration
4 h 14 min
When
Every day
Estimated price
$240 - $1,100
Flights from Indianapolis to Asheville via Charlotte
Ave. Duration
4 h 21 min
When
Every day
Estimated price
$210 - $1,100
Allegiant Air
Website
allegiantair.com
Flights from Indianapolis to Asheville via Orlando Sanford
Ave. Duration
5 h 35 min
When
Sunday
Estimated price
$220 - $1,000
Flights from Indianapolis to Asheville via Fort Lauderdale
Ave. Duration
6 h 11 min
When
Thursday and Sunday
Estimated price
$250 - $1,200
Flights from Indianapolis to Asheville via Punta Gorda
Ave. Duration
7 h 2 min
When
Saturday
Estimated price
$240 - $1,200
Train operators
Amtrak

Amtrak is a rail service that connects the US and three Canadian provinces. Covering 21,000 route miles (34,000km) Amtrak operates more than 300 trains daily. These medium and long distance intercity services operate at speeds of up to 240km/h, to more than 500 destinations. Founded in 1971, it is based in Washington, D.C. and offers four classes of travel: First Class, Sleeper, Business and Coach. Ticket fares are divided into five subclasses: Saver, Value, Flexible, Business and Premium. Amtrak trains are known for their wide seats, plug-in power, big windows and storage capabilities.

Rome2rio's guide to Amtrak
Contact Details
Phone
+1 1-800-872-7245
Website
amtrak.com
Train from Indianapolis Amtrak to Charlottesville Amtrak
Ave. Duration
15 h 11 min
Frequency
4 times a week
Estimated price
$85 - $250
Website
amtrak.com
Coach Seat
$85 - $130
Flexi Coach Seat
$150 - $230
Business Coach Seat
$170 - $250
Room
$360 - $550
Train from Charlottesville Amtrak to Greensboro Galyon Transportation Center
Ave. Duration
3 h 23 min
Frequency
Once daily
Estimated price
$35 - $90
Website
amtrak.com
Coach Seat
$35 - $60
Flexi Coach Seat
$65 - $100
Business Coach Seat
$65 - $90
Room
$190 - $260
Bus operators
Barons Bus
Phone
+1 888-378-3823
Website
baronsbus.com
Bus from Indianapolis, IN to Richmond, IN
Ave. Duration
1 h 50 min
Frequency
Once daily
Estimated price
$13 - $25
Book at
baronsbus.com
Bus from Richmond, IN to Columbus, OH
Ave. Duration
2 h
Frequency
Once daily
Estimated price
$15 - $28
Book at
baronsbus.com
Greyhound USA

Greyhound is a leading bus company based in Dallas, Texas, serving over 3800 destinations across North America, Mexico and Canada. Greyhound carries around 18 million passengers a year who travel 5.4 billion miles (8.6 billion km) a year on their fleet of around 1700 vehicles. For travel flexibility, you can board or get off a Greyhound bus at official Greyhound stations, partner stations and curbside stops. There are around 230 Greyhound stations across the US where you can both catch your bus and buy tickets, that are also available on the official website and via the mobile app.

Rome2rio's guide to Greyhound USA
Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from Columbus, Oh to Winston Salem, Nc
Ave. Duration
10 h 35 min
Frequency
Hourly
Estimated price
$40 - $110
Website
greyhound.com
Economy
$40 - $70
Flexible
$80 - $110
Bus from Winston Salem, Nc to Asheville, Nc
Ave. Duration
2 h 55 min
Frequency
Every 2 hours
Estimated price
$20 - $50
Website
greyhound.com
Economy
$20 - $30
Flexible
$35 - $50
Bus from Cincinnati, Oh to Columbus, Oh
Ave. Duration
1 h 45 min
Frequency
Hourly
Estimated price
$16 - $40
Website
greyhound.com
Economy
$16 - $25
Flexible
$29 - $40
Bus from Greensboro, Nc to Winston Salem, Nc
Ave. Duration
45 min
Frequency
Hourly
Estimated price
$9 - $20
Website
greyhound.com
Economy
$9 - $14
Flexible
$16 - $20
Megabus
Sunway Charters
Phone
+1 704-348-1200
Email
info@sunwaycharters.com
Website
sunwaycharters.com
Bus from Greensboro, Nc to Winston-Salem
Ave. Duration
40 min
Frequency
Twice daily
Schedules at
sunwaycharters.com

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Trips to Great Smoky Mountains National Park