There are 7 ways to get from Indianapolis to Florida Keys by plane, bus (Flixbus, Greyhound), car, shuttle, bus, or bus (Greyhound, Flixbus)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly Indianapolis to Key West International Airport
best- Fly from Indianapolis (IND) to Key West International Airport (EYW)plane IND - EYW
7h 12m$174–566Bus
- Take the bus from Indianapolis to Atlanta Bus Stationbus
- Take the bus from Atlanta Bus Station to Miami Airport Stationbus
- Take the bus from Miami Airport Station to Big Pine Keybus
31h 45m$211–348Drive 1,270.7 mi
- Drive from Indianapolis to Florida Keyscar 1,270.7 mi
23h 36m$232–335Fly Indianapolis to Fort Lauderdale–Hollywood International Airport, shuttle
- Fly from Indianapolis (IND) to Fort Lauderdale–Hollywood International Airport (FLL)plane IND - FLL
- Take a shuttle bus from Fort Lauderdale, FL - International Airport to Big Pine Key, FL
10h 16m$674–1,406Fly Indianapolis to Miami International Airport, shuttle
- Fly from Indianapolis (IND) to Miami International Airport (MIA)plane IND - MIA
- Take a shuttle bus from Miami, FL - International Airport to Big Pine Key, FL
10h 1m$264–736Bus to Covington, fly to Key West International Airport
- Take the bus from Indianapolis to Cincinnatibus
- Fly from Covington (CVG) to Key West International Airport (EYW)plane CVG - EYW
9h 43m$206–674Bus via Indianapolis Union Station
- Take the bus from Indianapolis Union Station to Atlanta Bus Stationbus
- Take the bus from Atlanta Bus Station to Miami Airport Stationbus
- Take the bus from Miami Airport Station to Big Pine Keybus
32h 5m$219–358
Indianapolis to Florida Keys by bus and foot
Comparing Your Travel Options
The cheapest way to get from Indianapolis to Florida Keys is to bus which costs $210 - $350 and takes 31h 45m.
The fastest way to get from Indianapolis to Florida Keys is to fly which takes 7h 12m and costs $170 - $600.
No, there is no direct bus from Indianapolis to Florida Keys. However, there are services departing from Indianapolis and arriving at Sugarloaf Key - Lower - Sugarloaf Lodge via Atlanta Bus Station, Miami Airport Station and Big Pine Key - CVS / MM30. The journey, including transfers, takes approximately 31h 45m.
The distance between Indianapolis and Florida Keys is 1124 miles. The road distance is 1278.2 miles.
The best way to get from Indianapolis to Florida Keys without a car is to bus which takes 31h 45m and costs $210 - $350.
It takes approximately 7h 12m to get from Indianapolis to Florida Keys, including transfers.
Indianapolis to Florida Keys bus services, operated by Flixbus USA, depart from Indianapolis station.
The best way to get from Indianapolis to Florida Keys is to fly which takes 7h 12m and costs $170 - $600. Alternatively, you can bus, which costs $210 - $350 and takes 31h 45m.
Indianapolis to Florida Keys bus services, operated by Flixbus USA, arrive at Atlanta Bus Station.
Yes, the driving distance between Indianapolis to Florida Keys is 1278 miles. It takes approximately 23h 36m to drive from Indianapolis to Florida Keys.
What companies run services between Indianapolis, IN, USA and Florida Keys, FL, USA?
Allegiant Air, Delta, and American Airlines fly from Indianapolis (IND) to Key West International Airport (EYW) every 4 hours. Alternatively, you can take a bus from Indianapolis to Florida Keys via Atlanta Bus Station, Miami Airport Station, Big Pine Key, Big Pine Key - CVS / MM30, and Sugarloaf Key - Lower - Sugarloaf Lodge in around 31h 45m.
- Website
- southwest.com
Flights from Indianapolis to Fort Lauderdale–Hollywood International Airport
- Ave. Duration
- 2h 35m
- When
- Every day
- Estimated price
- $120–600
Flights from Indianapolis to Fort Lauderdale–Hollywood International Airport via Nashville
- Ave. Duration
- 4h 20m
- When
- Saturday and Sunday
- Estimated price
- $120–650
Flights from Indianapolis to Miami International Airport
- Ave. Duration
- 2h 50m
- When
- Saturday
- Estimated price
- $110–550
Flights from Indianapolis to Miami International Airport via Nashville
- Ave. Duration
- 5h 40m
- When
- Tuesday, Wednesday, and Sunday
- Estimated price
- $110–600
Flights from Indianapolis to Miami International Airport via Orlando
- Ave. Duration
- 5h 50m
- When
- Every day
- Estimated price
- $110–550
- Website
- allegiantair.com
Flights from Indianapolis to Key West International Airport
- Ave. Duration
- 2h 35m
- When
- Thursday and Sunday
- Estimated price
- $95–470
Flights from Indianapolis to Key West International Airport via St. Petersburg
- Ave. Duration
- 5h 15m
- When
- Monday
- Estimated price
- $95–470
Flights from Indianapolis to Key West International Airport via Orlando Sanford
- Ave. Duration
- 5h 49m
- When
- Monday
- Estimated price
- $95–480
Flights from Indianapolis to Fort Lauderdale–Hollywood International Airport
- Ave. Duration
- 2h 34m
- When
- Monday, Thursday, Saturday, and Sunday
- Estimated price
- $120–600
Flights from Covington to Key West International Airport
- Ave. Duration
- 2h 30m
- When
- Monday and Friday
- Estimated price
- $110–550
Flights from Covington to Key West International Airport via Orlando Sanford
- Ave. Duration
- 5h 4m
- When
- Monday
- Estimated price
- $110–550
Flights from Covington to Key West International Airport via St. Petersburg
- Ave. Duration
- 5h 30m
- When
- Monday
- Estimated price
- $110–550
- Website
- delta.com
Flights from Indianapolis to Key West International Airport via Atlanta
- Ave. Duration
- 5h 10m
- When
- Every day
- Estimated price
- $95–470
Flights from Indianapolis to Fort Lauderdale–Hollywood International Airport via Atlanta
- Ave. Duration
- 4h 27m
- When
- Every day
- Estimated price
- $120–600
Flights from Covington to Key West International Airport via Atlanta
- Ave. Duration
- 5h 8m
- When
- Every day
- Estimated price
- $110–550
- Website
- aa.com
Flights from Indianapolis to Key West International Airport via Charlotte
- Ave. Duration
- 5h 33m
- When
- Every day
- Estimated price
- $100–490
Flights from Indianapolis to Miami International Airport
- Ave. Duration
- 2h 46m
- When
- Every day
- Estimated price
- $110–550
Flights from Covington to Key West International Airport via Miami International Airport
- Ave. Duration
- 5h 54m
- When
- Every day
- Estimated price
- $110–600
- Website
- flyfrontier.com
Flights from Indianapolis to Fort Lauderdale–Hollywood International Airport
- Ave. Duration
- 2h 38m
- When
- Monday, Wednesday, Friday, and Saturday
- Estimated price
- $160–550
- Website
- jetblue.com
Flights from Indianapolis to Fort Lauderdale–Hollywood International Airport
- Ave. Duration
- 2h 45m
- When
- Every day
- Estimated price
- $120–600
- Phone
- +1 (855) 626-8585
- Website
- Flixbus USA
Bus from Indianapolis to Atlanta Bus Station
- Ave. Duration
- 11h 5m
- Frequency
- Twice daily
- Estimated price
- $85–130
- Schedules at
- Flixbus USA
Bus from Atlanta Bus Station to Miami Airport Station
- Ave. Duration
- 13h 30m
- Frequency
- Once daily
- Estimated price
- $100–160
- Schedules at
- Flixbus USA
Bus from Indianapolis to Cincinnati
- Ave. Duration
- 2h
- Frequency
- Twice daily
- Estimated price
- $17–26
- Schedules at
- Flixbus USA
Bus from Atlanta Bus Station to Miami Airport Station
- Ave. Duration
- 13h 30m
- Frequency
- Once daily
- Estimated price
- $100–160
- Schedules at
- Flixbus USA
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- ifsr@greyhound.com
- Website
- Greyhound
Bus from Atlanta Bus Station to Miami Airport Station
- Ave. Duration
- 17h 20m
- Frequency
- Once daily
- Estimated price
- $120–180
- Website
- Greyhound
Bus from Miami Airport Station to Big Pine Key
- Ave. Duration
- 3h 40m
- Frequency
- 3 times a day
- Estimated price
- $22–35
- Website
- Greyhound
Bus from Indianapolis Union Station to Atlanta Bus Station
- Ave. Duration
- 11h 25m
- Frequency
- 4 times a day
- Estimated price
- $90–140
- Website
- Greyhound
Bus from Atlanta Bus Station to Miami Airport Station
- Ave. Duration
- 17h 20m
- Frequency
- Once daily
- Estimated price
- $120–180
- Website
- Greyhound
Bus from Miami Airport Station to Big Pine Key
- Ave. Duration
- 3h 40m
- Frequency
- 3 times a day
- Estimated price
- $22–35
- Website
- Greyhound
- Phone
- +1 (305) 289-9997
- groups@keysshuttle.com
- Website
- Keys Shuttle
Shuttle from Fort Lauderdale, FL - International Airport to Big Pine Key, FL
- Ave. Duration
- 3h 30m
- Frequency
- 3 times a day
- Estimated price
- $170–200
- Website
- Keys Shuttle
Shuttle from Miami, FL - International Airport to Big Pine Key, FL
- Ave. Duration
- 3h
- Frequency
- 3 times a day
- Estimated price
- $150–180
- Website
- Keys Shuttle
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Booking & Getting There
There are 969+ hotels available in Florida Keys.




