There are 5 ways to get from Indianapolis to Des Moines by plane, bus (Flixbus, Greyhound), car, train, or bus
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly from Indianapolis
best- Fly from Indianapolis (IND) to Des Moines (DSM)plane IND - DSM
5h 30m$79–403Bus
cheapest- Take the bus from Indianapolis to Chicago Bus Stationbus FlixBus 2512 / ...
- Take the bus from Chicago Bus Station to Des Moinesbus Greyhound US0123 / ...
11h 9m$72–137Drive 466.6 mi
- Drive from Indianapolis to Des Moinescar 466.6 mi
7h 55m$86–123Train to Purdue University Airport, fly
- Take the train from Indianapolis to Lafayette Amtrak Stationtrain
- Fly from Purdue University Airport (LAF) to Des Moines (DSM)plane LAF - DSM
7h 48m$85–380Train, bus
- Take the train from Indianapolis to Chicago Union Stationtrain Cardinal
- Take the bus from Chicago Bus Station to Des Moinesbus Greyhound US0123 / ...
12h 43m$94–200
Indianapolis to Des Moines by bus
Questions & Answers
The cheapest way to get from Indianapolis to Des Moines is to bus which costs $70 - $140 and takes 11h 9m.
The fastest way to get from Indianapolis to Des Moines is to fly which takes 5h 30m and costs $75 - $410.
No, there is no direct bus from Indianapolis to Des Moines. However, there are services departing from Indianapolis and arriving at Des Moines via Chicago Bus Station. The journey, including transfers, takes approximately 11h 9m.
The distance between Indianapolis and Des Moines is 430 miles. The road distance is 469.3 miles.
The best way to get from Indianapolis to Des Moines without a car is to bus which takes 11h 9m and costs $70 - $140.
It takes approximately 5h 30m to get from Indianapolis to Des Moines, including transfers.
Indianapolis to Des Moines bus services, operated by Flixbus USA, depart from Indianapolis station.
The best way to get from Indianapolis to Des Moines is to fly which takes 5h 30m and costs $75 - $410. Alternatively, you can bus, which costs $70 - $140 and takes 11h 9m.
Indianapolis to Des Moines bus services, operated by Flixbus USA, arrive at Chicago Bus Station.
Des Moines is 1h behind Indianapolis. It is currently 9:16 PM in Indianapolis and 8:16 PM in Des Moines.
What companies run services between Indianapolis, IN, USA and Des Moines, IA, USA?
American Airlines, Delta, and two other airlines fly from Indianapolis (IND) to Des Moines (DSM) hourly. Alternatively, you can take a bus from Indianapolis to Des Moines via Chicago Bus Station in around 11h 9m.
- Website
- delta.com
Flights from Indianapolis to Des Moines via Minneapolis
- Ave. Duration
- 4h 49m
- When
- Every day
- Estimated price
- $75–430
Flights from Indianapolis to Des Moines via Detroit
- Ave. Duration
- 5h 30m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $80–440
Flights from Indianapolis to Des Moines via Atlanta
- Ave. Duration
- 5h 30m
- When
- Every day
- Estimated price
- $100–550
- Website
- united.com
Flights from Indianapolis to Des Moines via Chicago O'Hare
- Ave. Duration
- 4h 48m
- When
- Every day
- Estimated price
- $60–380
Flights from Purdue University Airport to Des Moines via Chicago O'Hare
- Ave. Duration
- 4h 47m
- When
- Monday, Thursday, Friday, Saturday, and Sunday
- Estimated price
- $50–320
- Website
- aa.com
Flights from Indianapolis to Des Moines via Chicago O'Hare
- Ave. Duration
- 4h 19m
- When
- Every day
- Estimated price
- $60–380
- Website
- southwest.com
Flights from Indianapolis to Des Moines via Chicago Midway
- Ave. Duration
- 6h
- When
- Every day
- Estimated price
- $60–380
Rome2Rio's guide to Amtrak
Contact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Train from Indianapolis to Lafayette Amtrak Station
- Ave. Duration
- 1h 35m
- Frequency
- 3 times a week
- Estimated price
- $16–40
- Website
- https://www.amtrak.com/home.html
Train from Indianapolis to Chicago Union Station
- Ave. Duration
- 5h
- Frequency
- 3 times a week
- Estimated price
- $40–100
- Website
- https://www.amtrak.com/home.html
- Phone
- +1 (855) 626-8585
- Website
- flixbus.com
Bus from Indianapolis to Chicago Bus Station
- Ave. Duration
- 3h 35m
- Frequency
- Every 4 hours
- Estimated price
- $22–40
- Schedules at
- flixbus.com
Rome2Rio's guide to Greyhound USA
Contact Details
- Phone
- +1 214-849-8100
- ifsr@greyhound.com
- Website
- greyhound.com
Bus from Chicago Bus Station to Des Moines
- Ave. Duration
- 6h 34m
- Frequency
- 3 times a day
- Estimated price
- $50–100
- Website
- https://www.greyhound.com/
Want to know more about travelling around United States
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More Questions & Answers
Yes, the driving distance between Indianapolis to Des Moines is 469 miles. It takes approximately 7h 55m to drive from Indianapolis to Des Moines.
Book your Indianapolis to Des Moines bus tickets online with Omio and FlixBus.
There are 252+ hotels available in Des Moines.






