There are 10 ways to get from Indiana to South Carolina by plane, bus, train or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly Evansville to Charlotte  •  2 h 29 min

  1. EVV - CLT

$249 - $918

Cheapest option

Bus Megabus  •  20 h 44 min

  1. 0983 / ...

$93 - $131

8 alternative options

Fly Fort Wayne to Charlotte  •  2 h 38 min

  1. FWA - CLT

$403 - $1,335

Fly Indianapolis to Charlotte  •  3 h 46 min

  1. IND - CLT

$227 - $392

Fly South Bend to Charlotte  •  3 h 54 min

  1. SBN - CLT

$306 - $1,205

Bus to Chicago O'Hare, fly to Greenville/Spartanburg  •  4 h 29 min

  1. ORD - GSP

$198 - $632

Fly Chicago Midway to Charleston  •  5 h 14 min

  1. MDW - CHS

$197 - $636

Bus Greyhound USA  •  22 h 47 min

$103 - $220

Train, Amtrak Thruway  •  24 h 2 min

Drive  •  11 h 45 min

  1. 702.1 miles

$65 - $100

What companies run services between Indiana, USA and South Carolina, USA?

American Airlines and Delta fly from Evansville to Rock Hill 4 times a day. Alternatively, you can take a bus from Indianapolis to Florence via Marta Civic Center Station - Nb, Peachtree St Ne @ Ivan Allen Jr Blvd, Peachtree St Sw @ Brotherton Transportation Mall, and Atlanta, GA in around 20 h 44 min.

Airlines
American Airlines
Website
aa.com
Flights from Evansville to Charlotte
Ave. Duration
1 h 43 min
When
Every day
Estimated price
$150 - $750
Flights from Fort Wayne to Charlotte
Ave. Duration
1 h 46 min
When
Every day
Estimated price
$410 - $2,600
Flights from Fort Wayne to Charlotte via Chicago O'Hare
Ave. Duration
4 h 13 min
When
Every day
Estimated price
$410 - $2,600
Flights from Indianapolis to Charlotte
Ave. Duration
1 h 41 min
When
Every day
Estimated price
$280 - $700
Flights from South Bend to Charlotte
Ave. Duration
2 h 1 min
When
Every day
Estimated price
$220 - $1,100
Flights from Chicago O'Hare to Greenville/Spartanburg
Ave. Duration
1 h 53 min
When
Every day
Estimated price
$280 - $800
Flights from Chicago O'Hare to Greenville/Spartanburg via Charlotte
Ave. Duration
3 h 51 min
When
Every day
Estimated price
$280 - $800
Delta
Website
delta.com
Flights from Evansville to Charlotte via Atlanta
Ave. Duration
4 h
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$150 - $800
Flights from Evansville to Charlotte via Detroit
Ave. Duration
4 h 19 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$160 - $850
Flights from Fort Wayne to Charlotte via Detroit
Ave. Duration
4 h 3 min
When
Saturday and Sunday
Estimated price
$420 - $2,300
Flights from Fort Wayne to Charlotte via Atlanta
Ave. Duration
4 h 21 min
When
Every day
Estimated price
$420 - $2,300
Flights from South Bend to Charlotte via Atlanta
Ave. Duration
4 h 20 min
When
Every day
Estimated price
$230 - $1,200
Flights from South Bend to Charlotte via Detroit
Ave. Duration
4 h 3 min
When
Every day
Estimated price
$220 - $1,100
Flights from Chicago O'Hare to Greenville/Spartanburg via Atlanta
Ave. Duration
4 h 4 min
When
Monday to Friday
Estimated price
$260 - $1,300
Flights from Chicago O'Hare to Greenville/Spartanburg via Detroit
Ave. Duration
4 h 9 min
When
Saturday and Sunday
Estimated price
$260 - $1,300
Flights from Chicago Midway to Charleston via Atlanta
Ave. Duration
4 h 33 min
When
Every day
Estimated price
$280 - $1,400
Flights from Chicago Midway to Charleston via Detroit
Ave. Duration
4 h 33 min
When
Every day
Estimated price
$280 - $1,400
Southwest Airlines
Website
southwest.com
Flights from Indianapolis to Charlotte via Chicago Midway
Ave. Duration
3 h 40 min
When
Saturday
Estimated price
$320 - $650
Flights from Chicago Midway to Charleston
Ave. Duration
2 h
When
Every day
Estimated price
$350 - $1,600
Flights from Chicago Midway to Charleston via Baltimore
Ave. Duration
4 h 22 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$350 - $1,600
Flights from Chicago Midway to Charleston via St. Louis
Ave. Duration
4 h 30 min
When
Monday, Tuesday, Wednesday and Thursday
Estimated price
$350 - $1,600
Flights from Chicago Midway to Charleston via Nashville
Ave. Duration
4 h 45 min
When
Monday to Saturday
Estimated price
$350 - $1,600
United Airlines
Website
united.com
Flights from Chicago O'Hare to Greenville/Spartanburg
Ave. Duration
1 h 55 min
When
Every day
Estimated price
$280 - $1,100
Train operators
Amtrak
Phone
+1 1-800-872-7245
Website
amtrak.com
Train from Indianapolis Amtrak to Charlottesville Amtrak
Ave. Duration
15 h 11 min
Frequency
5 times a week
Estimated price
$85 - $250
Website
amtrak.com
Coach Seat
$85 - $130
Flexi Coach Seat
$150 - $230
Business Coach Seat
$170 - $250
Room
$360 - $550
Train from Richmond Staples Mill Amtrak to Florence Amtrak
Ave. Duration
5 h 21 min
Frequency
4 times a day
Estimated price
$50 - $140
Website
amtrak.com
Coach Seat
$50 - $80
Flexi Coach Seat
$90 - $140
Business Coach Seat
$95 - $140
Room
$240 - $340
Bus operators
Megabus
Phone
877-462-6342
Website
us.megabus.com
Bus from Indianapolis, IN to Marta Civic Center Station - Nb
Ave. Duration
10 h 47 min
Frequency
Twice daily
Estimated price
$50 - $65
Schedules at
us.megabus.com
South Eastern Stages
Phone
+1 877.836.7607 / 404.591.2750
Email
info@sestages.com
Website
southeasternstages.com
Bus from Atlanta, GA to Florence
Ave. Duration
8 h 30 min
Frequency
Every 4 hours
Estimated price
$40 - $65
Schedules at
southeasternstages.com
Bus from Columbia, SC to Florence, SC
Ave. Duration
1 h 38 min
Frequency
3 times a day
Estimated price
$19 - $27
Schedules at
southeasternstages.com
Barons Bus
Website
baronsbus.com
Bus from Indianapolis, IN to Richmond, IN
Ave. Duration
1 h 34 min
Frequency
Once daily
Estimated price
$13 - $25
Schedules at
baronsbus.com
Bus from Richmond, IN to Columbus, OH
Ave. Duration
2 h 10 min
Frequency
3 times a day
Estimated price
$15 - $28
Schedules at
baronsbus.com
Greyhound USA
Phone
+1 214-849-8100
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from Columbus, Oh to Columbia, Sc
Ave. Duration
15 h 5 min
Frequency
Hourly
Estimated price
$55 - $140
Website
greyhound.com
Economy
$55 - $95
Flexible
$100 - $140

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Questions & Answers

The distance between Indiana and South Carolina is 897 km. The road distance is 1123 km.

The cheapest way to get from Indiana to South Carolina is to drive which costs $65 - $100 and takes 11 h 45 min.

The quickest way to get from Indiana to South Carolina is to fly which takes 2 h 29 min and costs $240 - $950.

No, there is no direct bus from Indiana to South Carolina. However, there are services departing from Indianapolis, IN and arriving at Florence via Peachtree St Ne @ Ivan Allen Jr Blvd and Atlanta, GA. The journey, including transfers, takes approximately 20 h 44 min.

It takes approximately 2 h 29 min to get from Indiana to South Carolina, including transfers.