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There are 10 ways to get from Indiana to South Carolina by bus, plane, train or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Airport SuperSaver to Chicago O'Hare, fly to Greenville/Spartanburg  •  4 h 13 min

  1. Take the Airport SuperSaver from Highland, IN to Terminal 2, Chicago, IL - O'Hare Intl Airport
  2. Fly from Chicago O'Hare (ORD) to Greenville/Spartanburg (GSP) ORD - GSP

$198 - $632

Cheapest option

Bus Megabus  •  17 h 37 min

  1. Take the bus from Delaware St & Market St Indianapolis to Marta Civic Center Station - Nb
  2. Take the bus from Atlanta, GA to Florence, SC Atlanta

$88 - $126

8 alternative options

Fly Evansville to Charlotte, bus  •  4 h 52 min

  1. Fly from Evansville (EVV) to Charlotte (CLT) EVV - CLT
  2. Take the bus from Transit Center- Bay X to White Street Park and Ride

$180 - $836

Fly Fort Wayne to Charlotte, bus  •  5 h 1 min

  1. Fly from Fort Wayne (FWA) to Charlotte (CLT) FWA - CLT
  2. Take the bus from Transit Center- Bay X to White Street Park and Ride

$334 - $1,253

Fly Chicago Midway to Charleston  •  5 h 17 min

  1. Fly from Chicago Midway (MDW) to Charleston (CHS) MDW - CHS

$197 - $636

Fly Indianapolis to Charlotte, bus  •  6 h 11 min

  1. Fly from Indianapolis (IND) to Charlotte (CLT) IND - CLT
  2. Take the bus from Transit Center- Bay X to White Street Park and Ride

$158 - $310

Fly South Bend to Charlotte, bus  •  6 h 20 min

  1. Fly from South Bend (SBN) to Charlotte (CLT) SBN - CLT
  2. Take the bus from Transit Center- Bay X to White Street Park and Ride

$237 - $1,123

Bus Greyhound USA  •  23 h 15 min

  1. Take the bus from Indianapolis, IN to Richmond, IN
  2. Take the bus from Richmond, IN to Columbus, OH
  3. Take the bus from Columbus, Oh to Columbia, Sc
  4. Take the bus from Columbia, SC to Florence, SC

$103 - $222

Train, bus  •  23 h 52 min

  1. Take the train from Indianapolis Amtrak Station to Charlottesville Amtrak Station
  2. Take the bus from Charlottesville Amtrak Station to Richmond Staples Mill Road Amtrak Station
  3. Take the train from Richmond Staples Mill Road Amtrak Station to Florence Amtrak Station

Drive  •  11 h 45 min

  1. Drive from Indianapolis to Florence 702.1 miles

$65 - $100

Questions & Answers

The cheapest way to get from Indiana to South Carolina is to drive which costs $65 - $100 and takes 11 h 45 min.

More details

The quickest way to get from Indiana to South Carolina is to Airport SuperSaver and fly which costs $190 - $650 and takes 4 h 13 min.

More details

No, there is no direct bus from Indiana to South Carolina. However, there are services departing from Delaware St & Market St Indianapolis and arriving at Florence, SC via Peachtree St Ne @ Ivan Allen Jr Blvd and Atlanta, GA. The journey, including transfers, takes approximately 17 h 37 min.

More details

The distance between Indiana and South Carolina is 560 miles. The road distance is 702.1 miles.

Get driving directions

The best way to get from Indiana to South Carolina without a car is to bus which takes 17 h 37 min and costs $85 - $130.

More details

It takes approximately 4 h 13 min to get from Indiana to South Carolina, including transfers.

More details

Indiana to South Carolina bus services, operated by Megabus, depart from Delaware St & Market St Indianapolis station.

More details

The best way to get from Indiana to South Carolina is to fly which takes 5 h 17 min and costs $190 - $650. Alternatively, you can bus, which costs $85 - $130 and takes 17 h 37 min.

Mode details

The quickest flight from Chicago O'Hare Airport to Greenville/Spartanburg Airport is the direct flight which takes 1 h 42 min.

Search flights

Indiana to South Carolina bus services, operated by South Eastern Stages, arrive at Florence, SC station.

More details

Map of how to get from Indiana to South Carolina.
Launch map view
  • Distance: 560.4 miles
  • Duration: 4 h 13 min

What companies run services between Indiana, USA and South Carolina, USA?

Southwest Airlines and Delta fly from Hammond to North Charleston every 3 hours. Alternatively, you can take a bus from Indianapolis to Florence via Marta Civic Center Station - Nb, Peachtree St Ne @ Ivan Allen Jr Blvd, Peachtree St Sw @ Brotherton Transportation Mall, and Atlanta, GA in around 17 h 37 min.

Airlines
American Airlines
Website
aa.com
Flights from Chicago O'Hare to Greenville/Spartanburg
Ave. Duration
1 h 45 min
When
Every day
Estimated price
$280 - $800
Flights from Chicago O'Hare to Greenville/Spartanburg via Charlotte
Ave. Duration
3 h 50 min
When
Every day
Estimated price
$280 - $800
Flights from Evansville to Charlotte
Ave. Duration
1 h 51 min
When
Every day
Estimated price
$150 - $750
Flights from Fort Wayne to Charlotte
Ave. Duration
1 h 52 min
When
Every day
Estimated price
$410 - $2,600
Flights from Fort Wayne to Charlotte via Chicago O'Hare
Ave. Duration
4 h 17 min
When
Every day
Estimated price
$410 - $2,600
Flights from Indianapolis to Charlotte
Ave. Duration
1 h 47 min
When
Every day
Estimated price
$280 - $700
Flights from South Bend to Charlotte
Ave. Duration
2 h 11 min
When
Every day
Estimated price
$220 - $1,100
Delta
Website
delta.com
Flights from Evansville to Charlotte via Atlanta
Ave. Duration
4 h 4 min
When
Every day
Estimated price
$150 - $800
Flights from Evansville to Charlotte via Detroit
Ave. Duration
4 h 33 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$160 - $850
Flights from Fort Wayne to Charlotte via Atlanta
Ave. Duration
4 h 37 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$420 - $2,300
Flights from Chicago Midway to Charleston via Atlanta
Ave. Duration
4 h 9 min
When
Every day
Estimated price
$280 - $1,400
Flights from South Bend to Charlotte via Atlanta
Ave. Duration
4 h 51 min
When
Every day
Estimated price
$230 - $1,200
Flights from South Bend to Charlotte via Detroit
Ave. Duration
4 h 46 min
When
Every day
Estimated price
$220 - $1,100
Southwest Airlines
Website
southwest.com
Flights from Chicago Midway to Charleston
Ave. Duration
2 h
When
Every day
Estimated price
$350 - $1,600
Flights from Chicago Midway to Charleston via Nashville
Ave. Duration
3 h 45 min
When
Saturday
Estimated price
$350 - $1,600
Flights from Chicago Midway to Charleston via Baltimore
Ave. Duration
4 h 26 min
When
Monday to Friday
Estimated price
$350 - $1,600
Flights from Chicago Midway to Charleston via St. Louis
Ave. Duration
4 h 30 min
When
Sunday
Estimated price
$350 - $1,600
Flights from Indianapolis to Charlotte via Chicago Midway
Ave. Duration
3 h 50 min
When
Wednesday
Estimated price
$320 - $650
United Airlines
Website
united.com
Flights from Chicago O'Hare to Greenville/Spartanburg
Ave. Duration
1 h 55 min
When
Every day
Estimated price
$280 - $1,100
Flights from South Bend to Charlotte via Chicago O'Hare
Ave. Duration
4 h 27 min
When
Every day
Estimated price
$250 - $1,200
Train operators
Amtrak

Amtrak is a rail service that connects the US and three Canadian provinces. Covering 21,000 route miles (34,000km) Amtrak operates more than 300 trains daily. These medium and long distance intercity services operate at speeds of up to 240km/h, to more than 500 destinations. Founded in 1971, it is based in Washington, D.C. and offers four classes of travel: First Class, Sleeper, Business and Coach. Ticket fares are divided into five subclasses: Saver, Value, Flexible, Business and Premium. Amtrak trains are known for their wide seats, plug-in power, big windows and storage capabilities.

Rome2rio's guide to Amtrak
Contact Details
Phone
+1 215-856-7924
Website
amtrak.com
Train from Indianapolis Amtrak Station to Charlottesville Amtrak Station
Ave. Duration
15 h 11 min
Frequency
4 times a week
Estimated price
$85 - $250
Website
amtrak.com
Coach Seat
$85 - $130
Flexi Coach Seat
$150 - $230
Business Coach Seat
$170 - $250
Room
$360 - $550
Train from Richmond Staples Mill Road Amtrak Station to Florence Amtrak Station
Ave. Duration
5 h 21 min
Frequency
Twice daily
Estimated price
$50 - $140
Website
amtrak.com
Coach Seat
$50 - $80
Flexi Coach Seat
$90 - $140
Business Coach Seat
$95 - $140
Room
$240 - $340
Bus operators
Airport SuperSaver
Bus from Highland, IN to Terminal 2, Chicago, IL - O'Hare Intl Airport
Ave. Duration
1 h 10 min
Frequency
Hourly
Schedules at
airportsupersaver.com
Book at
airportsupersaver.com
Charlotte Area Transit System
Phone
+1 704-336-7433
Email
telltransit@charlottenc.gov
Website
charlottenc.gov
Bus from Transit Center- Bay X to White Street Park and Ride
Ave. Duration
1 h 12 min
Frequency
3 times a day
Estimated price
$3 - $5
Schedules at
charlottenc.gov
Megabus
Phone
877-462-6342
Website
us.megabus.com
Bus from Delaware St & Market St Indianapolis to Marta Civic Center Station - Nb
Ave. Duration
10 h 40 min
Frequency
Twice daily
Estimated price
$50 - $65
Book at
megabus.com
South Eastern Stages
Phone
+1 877.836.7607 / 404.591.2750
Email
info@sestages.com
Website
southeasternstages.com
Bus from Atlanta, GA to Florence, SC
Ave. Duration
5 h 30 min
Frequency
Once daily
Estimated price
$35 - $60
Schedules at
southeasternstages.com
Bus from Columbia, SC to Florence, SC
Ave. Duration
1 h 20 min
Frequency
3 times a day
Estimated price
$19 - $29
Schedules at
southeasternstages.com
Barons Bus
Phone
+1 888-378-3823
Website
baronsbus.com
Bus from Indianapolis, IN to Richmond, IN
Ave. Duration
1 h 50 min
Frequency
Once daily
Estimated price
$13 - $25
Book at
baronsbus.com
Bus from Richmond, IN to Columbus, OH
Ave. Duration
2 h
Frequency
Once daily
Estimated price
$15 - $28
Book at
baronsbus.com
Greyhound USA

Greyhound is a leading bus company based in Dallas, Texas, serving over 3800 destinations across North America, Mexico and Canada. Greyhound carries around 18 million passengers a year who travel 5.4 billion miles (8.6 billion km) a year on their fleet of around 1700 vehicles. For travel flexibility, you can board or get off a Greyhound bus at official Greyhound stations, partner stations and curbside stops. There are around 230 Greyhound stations across the US where you can both catch your bus and buy tickets, that are also available on the official website and via the mobile app.

Rome2rio's guide to Greyhound USA
Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from Columbus, Oh to Columbia, Sc
Ave. Duration
15 h 5 min
Frequency
Every 4 hours
Estimated price
$55 - $140
Website
greyhound.com
Economy
$55 - $95
Flexible
$100 - $140
Amtrak

Amtrak is a rail service that connects the US and three Canadian provinces. Covering 21,000 route miles (34,000km) Amtrak operates more than 300 trains daily. These medium and long distance intercity services operate at speeds of up to 240km/h, to more than 500 destinations. Founded in 1971, it is based in Washington, D.C. and offers four classes of travel: First Class, Sleeper, Business and Coach. Ticket fares are divided into five subclasses: Saver, Value, Flexible, Business and Premium. Amtrak trains are known for their wide seats, plug-in power, big windows and storage capabilities.

Rome2rio's guide to Amtrak
Contact Details
Phone
+1 215-856-7924
Website
amtrak.com
Bus from Charlottesville Amtrak Station to Richmond Staples Mill Road Amtrak Station
Ave. Duration
1 h 20 min
Frequency
Twice daily
Website
amtrak.com

Want to know more about travelling around United States

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More Questions & Answers

Yes, the driving distance between Indiana to South Carolina is 702 miles. It takes approximately 11 h 45 min to drive from Indiana to South Carolina.

Get driving directions

United Airlines and American Airlines offer flights from Chicago O'Hare Airport to Greenville/Spartanburg Airport.

Search flights

There are 17+ hotels available in South Carolina. Prices start at $49 USD per night.

More details

The best way to get from Indiana to Evansville Airport is to taxi which takes 12 min and costs $23 - $28.

More details