There are 10 ways to get from Indiana to Ithaca by train, plane, bus, bus (Greyhound, Flixbus), car, or bus (Greyhound)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Train to Chicago Midway International Airport, fly to Rochester, bus
best- Take the train from Gary to Museum Campus/11th Street Sationtrain
- Fly from Chicago Midway International Airport (MDW) to Rochester (ROC)plane MDW - ROC
- Take the bus from Rochester to Ithacabus
7h 3m$148–742Bus via Cleveland
cheapest- Take the bus from Indianapolis, IN to Toledobus
- Take the bus from Toledo Bus Stop to Cleveland Bus Stationbus
- Take the bus from Cleveland, OH to Buffalo, NYbus
- Take the bus from Buffalo to Ithacabus
15h 35m$83–205Bus, train
- Take the bus from Indianapolis, IN to Toledobus
- Take the train from Toledo to Rochestertrain
- Take the bus from Rochester to Ithacabus 231
14h 14m$137–325Drive 620.7 mi
- Drive from Indianapolis to Ithacacar 620.7 mi
11h 16m$114–164Train to Chicago O'Hare International Airport, fly to Rochester, bus
- Take the train from Gary to Van Buren St.train
- Fly from Chicago O'Hare International Airport (ORD) to Rochester (ROC)plane ORD - ROC
- Take the bus from Rochester to Ithacabus
7h 35m$249–552Train to Chicago O'Hare International Airport, fly to Wilkes-Barre/Scranton International Airport, bus
- Take the train from Gary to Van Buren St.train
- Fly from Chicago O'Hare International Airport (ORD) to Wilkes-Barre/Scranton International Airport (AVP)plane ORD - AVP
- Take the bus from Scranton, Pa to Ithacabus
8h 30m$137–523Train to Chicago O'Hare International Airport, fly to Syracuse Hancock International Airport, bus
- Take the train from Gary to Van Buren St.train
- Fly from Chicago O'Hare International Airport (ORD) to Syracuse Hancock International Airport (SYR)plane ORD - SYR
- Take the bus from Syracuse Bus Station to Ithacabus
8h 3m$120–654Train to Chicago Midway International Airport, fly to Buffalo Niagara International Airport, bus
- Take the train from Gary to Museum Campus/11th Street Sationtrain
- Fly from Chicago Midway International Airport (MDW) to Buffalo Niagara International Airport (BUF)plane MDW - BUF
- Take the bus from Buffalo Niagara International Airport to Ithacabus
8h 23m$208–1,248Train, bus
- Take the train from Indianapolis to Chicago Union Stationtrain
- Take the train from Chicago Union Station to Syracuse Regional Transportation Centertrain
- Take the bus from Syracuse Bus Station to Ithacabus
21h 7m$241–529Bus
- Take the bus from Indianapolis Union Station to Harrisburg Bus Stationbus
- Take the bus from Harrisburg, Pa to Scranton, Pabus 770
- Take the bus from Scranton, Pa to Ithacabus 246
21h 40m$145–320
Indiana to Ithaca by bus and train
Questions & Answers
The cheapest way to get from Indiana to Ithaca is to drive which costs $110 - $170 and takes 11h 16m.
The fastest way to get from Indiana to Ithaca is to train and fly and bus which takes 7h 3m and costs $140 - $750.
No, there is no direct bus from Indiana to Ithaca. However, there are services departing from Indianapolis, IN and arriving at Ithaca via Toledo Bus Stop, Cleveland, OH and Buffalo. The journey, including transfers, takes approximately 15h 35m.
The distance between Indiana and Ithaca is 661 miles. The road distance is 624.4 miles.
The best way to get from Indiana to Ithaca without a car is to bus and train which takes 14h 14m and costs $130 - $330.
It takes approximately 7h 3m to get from Indiana to Ithaca, including transfers.
Indiana to Ithaca bus services, operated by Barons Bus, depart from Indianapolis, IN station.
Indiana to Ithaca bus services, operated by Barons Bus, arrive at Toledo station.
Yes, the driving distance between Indiana to Ithaca is 624 miles. It takes approximately 11h 16m to drive from Indiana to Ithaca.
Book your Indiana to Ithaca bus tickets online with Omio.
What companies run services between Indiana, USA and Ithaca, NY, USA?
You can take a bus from Indianapolis, IN to Ithaca via Toledo Bus Stop, Cleveland Bus Station, Cleveland, OH, Buffalo, NY, and Buffalo in around 15h 35m.
- Website
- aa.com
Flights from Chicago O'Hare International Airport to Rochester
- Ave. Duration
- 1h 52m
- When
- Every day
- Estimated price
- $75–440
Flights from Chicago O'Hare International Airport to Rochester via Reagan Washington
- Ave. Duration
- 4h 23m
- When
- Monday to Friday
- Estimated price
- $100–550
Flights from Chicago O'Hare International Airport to Wilkes-Barre/Scranton International Airport
- Ave. Duration
- 2h 1m
- When
- Every day
- Estimated price
- $70–400
Flights from Chicago O'Hare International Airport to Syracuse Hancock International Airport
- Ave. Duration
- 1h 58m
- When
- Every day
- Estimated price
- $100–600
Flights from Chicago O'Hare International Airport to Syracuse Hancock International Airport via Philadelphia
- Ave. Duration
- 4h 13m
- When
- Every day
- Estimated price
- $130–700
Flights from Chicago O'Hare International Airport to Syracuse Hancock International Airport via Reagan Washington
- Ave. Duration
- 4h 24m
- When
- Sunday
- Estimated price
- $130–700
- Website
- southwest.com
Flights from Chicago Midway International Airport to Rochester
- Ave. Duration
- 1h 32m
- When
- Every day
- Estimated price
- $100–650
Flights from Chicago Midway International Airport to Rochester via Baltimore
- Ave. Duration
- 4h
- When
- Tuesday, Wednesday, and Saturday
- Estimated price
- $150–800
Flights from Chicago Midway International Airport to Buffalo Niagara International Airport
- Ave. Duration
- 1h 27m
- When
- Every day
- Estimated price
- $180–1,200
- Website
- united.com
Flights from Chicago O'Hare International Airport to Rochester
- Ave. Duration
- 1h 53m
- When
- Every day
- Estimated price
- $75–440
Flights from Chicago O'Hare International Airport to Wilkes-Barre/Scranton International Airport
- Ave. Duration
- 2h 3m
- When
- Every day
- Estimated price
- $70–400
Flights from Chicago O'Hare International Airport to Wilkes-Barre/Scranton International Airport via Washington Dulles
- Ave. Duration
- 4h 40m
- When
- Every day
- Estimated price
- $80–440
Flights from Chicago O'Hare International Airport to Syracuse Hancock International Airport
- Ave. Duration
- 1h 58m
- When
- Every day
- Estimated price
- $100–600
Flights from Chicago O'Hare International Airport to Syracuse Hancock International Airport via Washington Dulles
- Ave. Duration
- 4h 23m
- When
- Every day
- Estimated price
- $130–700
- Website
- delta.com
Flights from Chicago Midway International Airport to Rochester via Detroit
- Ave. Duration
- 3h 25m
- When
- Every day
- Estimated price
- $100–650
Flights from Chicago O'Hare International Airport to Rochester via Detroit
- Ave. Duration
- 4h 19m
- When
- Every day
- Estimated price
- $75–440
Flights from Chicago Midway International Airport to Buffalo Niagara International Airport via Detroit
- Ave. Duration
- 3h 21m
- When
- Every day
- Estimated price
- $180–1,200
- Phone
- +1 219-926-5744
- Website
- mysouthshoreline.com
Train from Gary to Museum Campus/11th Street Sation
- Ave. Duration
- 49 min
- Frequency
- Hourly
- Estimated price
- $7–8
- Schedules at
- mysouthshoreline.com
- Adults 14-64
- $7–8
Train from Gary to Van Buren St.
- Ave. Duration
- 52 min
- Frequency
- Hourly
- Estimated price
- $7–9
- Schedules at
- mysouthshoreline.com
- Adults 14-64
- $7–9
Rome2Rio's guide to Amtrak
Contact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Train from Toledo to Rochester
- Ave. Duration
- 6h 29m
- Frequency
- Twice daily
- Estimated price
- $95–210
- Website
- https://www.amtrak.com/home.html
Train from Indianapolis to Chicago Union Station
- Ave. Duration
- 5h
- Frequency
- 3 times a week
- Estimated price
- $50–120
- Website
- https://www.amtrak.com/home.html
Train from Chicago Union Station to Syracuse Regional Transportation Center
- Ave. Duration
- 12h 58m
- Frequency
- Twice daily
- Estimated price
- $180–400
- Website
- https://www.amtrak.com/home.html
- Phone
- +1 800-858-8555
- Website
- trailways.com
Bus from Rochester to Ithaca
- Ave. Duration
- 1h 50m
- Frequency
- 3 times a day
- Estimated price
- $20–55
- Website
- https://trailways.com
- Schedules at
- https://trailways.com/schedules/
- Saver
- $20–55
- Flexible
- $40–55
Bus from Scranton, Pa to Ithaca
- Ave. Duration
- 2h 30m
- Frequency
- Twice daily
- Estimated price
- $22–65
- Website
- https://trailways.com
- Schedules at
- https://trailways.com/schedules/
- Saver
- $22–65
- Flexible
- $45–65
Bus from Harrisburg, Pa to Scranton, Pa
- Ave. Duration
- 3h 15m
- Frequency
- Once daily
- Estimated price
- $24–75
- Website
- https://trailways.com
- Schedules at
- https://trailways.com/schedules/
- Saver
- $24–75
- Flexible
- $45–75
- Phone
- +1 888-378-3823
- info@baronsbus.com
- Website
- baronsbus.com
Bus from Indianapolis, IN to Toledo
- Ave. Duration
- 3h 55m
- Frequency
- Once daily
- Estimated price
- $21–65
- Website
- https://baronsbus.com
Bus from Toledo Bus Stop to Cleveland Bus Station
- Ave. Duration
- 1h 45m
- Frequency
- Once daily
- Estimated price
- $11–45
- Website
- https://baronsbus.com
Bus from Cleveland, OH to Buffalo, NY
- Ave. Duration
- 3h 10m
- Frequency
- Once daily
- Estimated price
- $18–60
- Website
- https://baronsbus.com
Rome2Rio's guide to Greyhound USA
Contact Details
- Phone
- +1 214-849-8100
- ifsr@greyhound.com
- Website
- greyhound.com
Bus from Toledo Bus Stop to Cleveland Bus Station
- Ave. Duration
- 1h 45m
- Frequency
- 4 times a day
- Estimated price
- $19–40
- Website
- https://www.greyhound.com/
Bus from Cleveland, OH to Buffalo, NY
- Ave. Duration
- 4h
- Frequency
- Once daily
- Estimated price
- $30–65
- Website
- https://www.greyhound.com/
Bus from Indianapolis Union Station to Harrisburg Bus Station
- Ave. Duration
- 13h 55m
- Frequency
- 3 times a day
- Estimated price
- $95–180
- Website
- https://www.greyhound.com/
- Phone
- +1 (855) 626-8585
- Website
- flixbus.com
Bus from Buffalo to Ithaca
- Ave. Duration
- 3h 45m
- Frequency
- Once daily
- Estimated price
- $20–35
- Schedules at
- flixbus.com
Bus from Syracuse Bus Station to Ithaca
- Ave. Duration
- 1h 9m
- Frequency
- 5 times a week
- Estimated price
- $7–14
- Schedules at
- flixbus.com
Bus from Buffalo Niagara International Airport to Ithaca
- Ave. Duration
- 3h 25m
- Frequency
- Once daily
- Estimated price
- $19–35
- Schedules at
- flixbus.com
Want to know more about travelling around United States
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Travelling to the US: What do I need to know?
Read the travel guide
Why you should take the train in the US
Read the travel guide
Need to know: Greyhound
Read the travel guide
More Questions & Answers
There are 66+ hotels available in Ithaca.












