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How to get fromHyannis to San Diegoby bus, plane, train, bus (Greyhound, Amtrak) or car

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There are 8 ways to get from Hyannis to San Diego by bus, plane, train, bus (Greyhound, Amtrak), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Boston Logan Airport, fly

    best
    1. Take the bus from Hyannis Transportation Center to Logan International Airportbus
    2. Fly from Boston Logan Airport (BOS) to San Diego International Airport (SAN)planeBOS - SAN
    9h 51m
    $170–511

  2. Bus, train

    1. Take the bus from Hyannis Transportation Center to Boston South Stationbus
    2. Take the train from Boston to Chicago Union Stationtrain
    3. Take the train from Chicago Union Station to Fullerton Amtrak Stationtrain
    4. Take the train from Fullerton Amtrak Station to San Diegotrain
    3d
    $340–1,050

  3. Bus

    1. Take the bus from Hyannis Transportation Center to Boston South Busesbus
    2. Take the bus from South Station to Port Authority Bus Terminalbus
    3. Take the bus from Port Authority Bus Terminal to St Louis Bus Stationbus
    4. Take the bus from St Louis Bus Station to Los Angeles Union Stationbus
    5. Take the bus from Los Angeles to San Diegobus
    3d 3h

  4. Drive 2,983.8 mi

    1. Drive from Hyannis to San Diegocar2,983.8 mi
    2d 2h
    $545–787

  5. Fly from Barnstable Municipal Airport

    1. Fly from Barnstable Municipal Airport (HYA) to San Diego International Airport (SAN)planeHYA - SAN
    10h 3m
    $255–1,108

  6. Bus to Provincetown Municipal Airport, fly

    1. Take the bus from Hyannis Transportation Center to Provincetownbus
    2. Fly from Provincetown Municipal Airport (PVC) to San Diego International Airport (SAN)planePVC - SAN
    15h 15m
    $242–1,040

  7. Bus, train to Theodore Francis Green State Airport, fly

    1. Take the bus from Hyannis Transportation Center to Boston South Stationbus
    2. Take the train from Boston to Providencetrain
    3. Fly from Theodore Francis Green State Airport (PVD) to San Diego International Airport (SAN)planePVD - SAN
    12h 55m
    $179–1,393

  8. Bus, train via New York

    1. Take the bus from Hyannis Transportation Center to Boston South Busesbus
    2. Take the bus from Boston to New York Midtownbus
    3. Take the bus from New York Midtown to Chicago Bus Stationbus
    4. Take the train from Chicago Union Station to Fullerton Amtrak Stationtrain
    5. Take the train from Fullerton Amtrak Station to San Diegotrain
    3d 3h
    $332–664

Hyannis to San Diego by bus and train

Calendar7Weekly Services
Duration3dAverage Duration
Ticket$340Cheapest Price
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Questions & Answers

What companies run services between Hyannis, MA, USA and San Diego, CA, USA?

You can take a bus from Hyannis Transportation Center to San Diego via Boston, Bus Terminal South Station, South Station, Port Authority Bus Terminal, St Louis Bus Station, Los Angeles Union Station, and Los Angeles in around 3d 3h. Alternatively, American Airlines, Cape Air, and JetBlue Airways fly from Barnstable Municipal Airport (HYA) to San Diego International Airport (SAN) 5 times a day.

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