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How to get fromHyannis to Myrtle Beachby plane, bus, train, bus (Flixbus, Greyhound), car, or bus (Greyhound)

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There are 7 ways to get from Hyannis to Myrtle Beach by plane, bus, train, bus (Flixbus, Greyhound), car, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Barnstable Municipal Airport

    best
    1. Fly from Barnstable Municipal Airport (HYA) to Myrtle Beach (MYR)plane plane HYA - MYR
    5h 21m
    $88–423

  2. Bus, train

    1. Take the bus from Hyannis to Bostonbus bus
    2. Take the train from Boston to Petersburg Amtrak Stationtrain train
    3. Take the train from Petersburg Amtrak Station to Fayetteville Amtrak Stationtrain train
    4. Take the bus from Fayetteville Bus Station to Myrtle Beach Bus Stationbus bus
    22h
    $248–624

  3. Bus

    1. Take the bus from Hyannis Transportation Center to Boston South Busesbus bus
    2. Take the bus from Boston to Richmondbus bus
    3. Take the bus from Richmond to Raleigh Bus Stationbus bus
    4. Take the bus from Raleigh Bus Station to Myrtle Beach Bus Stationbus bus
    24h 40m
    $174–270

  4. Drive  886.3 mi

    1. Drive from Hyannis to Myrtle Beachcar car 886.3 mi
    16h 55m
    $162–234

  5. Bus to Boston Logan Airport, fly

    1. Take the bus from Hyannis to Bostonbus bus
    2. Fly from Boston Logan Airport (BOS) to Myrtle Beach (MYR)plane plane BOS - MYR
    5h 14m
    $101–450

  6. Bus, train via New York

    1. Take the bus from Hyannis Transportation Center to Boston South Busesbus bus
    2. Take the train from Boston to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the train from Ny Moynihan Train Hall At Penn Station to Fayetteville Amtrak Stationtrain train
    4. Take the bus from Fayetteville Bus Station to Myrtle Beach Bus Stationbus bus
    22h 26m
    $251–1,215

  7. Bus via New York

    1. Take the bus from Hyannis to Providencebus bus
    2. Take the bus from Providence to New Yorkbus bus
    3. Take the bus from Times Square – 37th St. to Norfolk, VA - Best Squarebus bus
    4. Take the bus from Norfolk to Myrtle Beach Bus Stationbus bus
    24h 56m
    $156–243

Hyannis to Myrtle Beach by bus, foot, and train

Calendar7Weekly Services
Duration22hAverage Duration
Ticket$248Cheapest Price
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Comparing Your Travel Options

Map of how to get from Hyannis to Myrtle Beach.ExpandLaunch map view
  • Distance: 728.2 mi
  • Duration: 5h 21m

What companies run services between Hyannis, MA, USA and Myrtle Beach, SC, USA?

American Airlines, Cape Air, and Delta fly from Barnstable Municipal Airport (HYA) to Myrtle Beach (MYR) twice daily. Alternatively, you can take a bus from Hyannis Transportation Center to Myrtle Beach Bus Station via Boston, South Station, Boston, Richmond, Richmond, and Raleigh Bus Station in around 24h 40m.

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