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How to get fromHyannis to Buffaloby plane, bus (Flixbus, Greyhound), bus, train or car

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There are 6 ways to get from Hyannis to Buffalo by plane, bus (Flixbus, Greyhound), bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Barnstable Municipal Airport

    best
    1. Fly from Barnstable Municipal Airport (HYA) to Buffalo Niagara International Airport (BUF)planeHYA - BUF
    7h 9m
    $185–1,116

  2. Bus via BNIA Driveway & BNIA Terminal

    cheapest
    1. Take the bus from Hyannis Transportation Center to Boston South Busesbus
    2. Take the bus from Boston, MA to Syracuse, NYbus
    3. Take the bus from Syracuse, NY to Buffalo, NYbus
    14h 24m
    $72–195

  3. Bus

    1. Take the bus from Hyannis Transportation Center to Boston South Busesbus
    2. Take the bus from Boston to Syracuse Bus Stationbus
    3. Take the bus from Syracuse Bus Station to Buffalobus
    13h 9m
    $103–220

  4. Bus, train

    1. Take the bus from Hyannis Transportation Center to Boston South StationbusHyannis
    2. Take the train from Boston to Buffalo Depew StationtrainLake Shore Limited
    15h 40m
    $119–961

  5. Drive 513.3 mi

    1. Drive from Hyannis to Buffalocar513.3 mi
    9h 2m
    $94–136

  6. Bus to Boston Logan Airport, fly

    1. Take the bus from Hyannis Transportation Center to Logan International Airportbus
    2. Fly from Boston Logan Airport (BOS) to Buffalo Niagara International Airport (BUF)planeBOS - BUF
    6h 10m
    $182–1,066

Hyannis to Buffalo by bus

Calendar13Weekly Buses
Duration13h 9mAverage Duration
Ticket$103Cheapest Price
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Questions & Answers

What companies run services between Hyannis, MA, USA and Buffalo, NY, USA?

Cape Air, JetBlue Airways, and three other airlines fly from Barnstable Municipal Airport (HYA) to Buffalo Niagara International Airport (BUF) 3 times a day. Alternatively, you can take a bus from Hyannis Transportation Center to Buffalo via Boston, Bus Terminal South Station, Boston, and Syracuse Bus Station in around 13h 9m.

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