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How to get fromHyannis to Buffaloby plane, bus (Flixbus, Greyhound), bus, train or car

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There are 7 ways to get from Hyannis to Buffalo by plane, bus (Flixbus, Greyhound), bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Barnstable Municipal Airport

    best
    1. Fly from Barnstable Municipal Airport (HYA) to Buffalo Niagara International Airport (BUF)plane plane HYA - BUF
    6h 44m
    $165–1,038

  2. Bus via BNIA Driveway & BNIA Terminal

    cheapest
    1. Take the bus from Hyannis Transportation Center to Boston South Busesbus bus
    2. Take the bus from Boston, MA to Syracuse, NYbus bus
    3. Take the bus from Syracuse, NY to Buffalo, NYbus bus
    14h 24m
    $72–195

  3. Bus

    1. Take the bus from Hyannis Transportation Center to Boston South Busesbus bus
    2. Take the bus from Boston to Syracuse Bus Stationbus bus
    3. Take the bus from Syracuse Bus Station to Buffalobus bus
    13h 16m
    $97–200

  4. Bus, train

    1. Take the bus from Hyannis Transportation Center to Boston South Stationbus bus Hyannis
    2. Take the train from Boston to Buffalo Depew Stationtrain train Lake Shore Limited
    15h 40m
    $139–561

  5. Drive 513.2 mi

    1. Drive from Hyannis to Buffalocar car 513.2 mi
    9h 5m
    $94–136

  6. Bus to Boston Logan Airport, fly

    1. Take the bus from Hyannis Transportation Center to Logan International Airportbus bus
    2. Fly from Boston Logan Airport (BOS) to Buffalo Niagara International Airport (BUF)plane plane BOS - BUF
    6h 10m
    $182–1,066

  7. Bus to Provincetown Municipal Airport, fly

    1. Take the bus from Hyannis Transportation Center to Provincetownbus bus
    2. Fly from Provincetown Municipal Airport (PVC) to Buffalo Niagara International Airport (BUF)plane plane PVC - BUF
    8h 45m
    $341–1,282

Hyannis to Buffalo by bus

Calendar12Weekly Buses
Duration13h 16mAverage Duration
Ticket$97Cheapest Price
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Questions & Answers

What companies run services between Hyannis, MA, USA and Buffalo, NY, USA?

American Airlines, JetBlue Airways, and Cape Air fly from Barnstable Municipal Airport (HYA) to Buffalo Niagara International Airport (BUF) 4 times a day. Alternatively, you can take a bus from Hyannis Transportation Center to Buffalo via Boston, Bus Terminal South Station, Boston, and Syracuse Bus Station in around 13h 16m.

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