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How to get fromHyannis to Buffaloby plane, bus (Greyhound, Flixbus), bus, train or car

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There are 6 ways to get from Hyannis to Buffalo by plane, bus (Greyhound, Flixbus), bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Barnstable Municipal Airport

    best
    1. Fly from Barnstable Municipal Airport (HYA) to Buffalo Niagara International Airport (BUF)plane plane HYA - BUF
    5h 48m
    $227–1,389

  2. Bus

    cheapest
    1. Take the bus from Hyannis Transportation Center to Boston South Busesbus bus
    2. Take the bus from Boston to Syracuse Bus Stationbus bus
    3. Take the bus from Syracuse Bus Station to Buffalobus bus
    13h 7m
    $80–185

  3. Bus, train

    1. Take the bus from Hyannis Transportation Center to Boston South Stationbus bus Hyannis
    2. Take the train from Boston to Buffalo Depew Stationtrain train Lake Shore Limited
    15h 40m
    $135–377

  4. Drive 513.2 mi

    1. Drive from Hyannis to Buffalocar car 513.2 mi
    9h 5m
    $94–136

  5. Bus to Boston Logan Airport, fly

    1. Take the bus from Hyannis Transportation Center to Logan International Airportbus bus
    2. Fly from Boston Logan Airport (BOS) to Buffalo Niagara International Airport (BUF)plane plane BOS - BUF
    6h 9m
    $163–964

  6. Bus via New York

    1. Take the bus from Hyannis Transportation Center to Providence Bus Terminalbus bus
    2. Take the bus from Peter Pan Bus Terminal to Port Authority Bus Terminalbus bus
    3. Take the bus from New York to Buffalobus bus
    16h
    $110–402

Hyannis to Buffalo by bus

Calendar12Weekly Buses
Duration13h 7mAverage Duration
Ticket$80Cheapest Price
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Questions & Answers

What companies run services between Hyannis, MA, USA and Buffalo, NY, USA?

JetBlue Airways, Cape Air, and American Airlines fly from Barnstable Municipal Airport (HYA) to Buffalo Niagara International Airport (BUF) 5 times a day. Alternatively, you can take a bus from Hyannis Transportation Center to Buffalo via Boston, Bus Terminal South Station, Boston, and Syracuse Bus Station in around 13h 7m.

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