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How to get fromHyannis to Buffaloby plane, bus (Greyhound), bus, train, car, or bus (Flixbus)

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There are 6 ways to get from Hyannis to Buffalo by plane, bus (Greyhound), bus, train, car, or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Barnstable Municipal Airport

    best
    1. Fly from Barnstable Municipal Airport (HYA) to Buffalo Niagara International Airport (BUF)plane plane HYA - BUF
    5h 12m
    $118–706

  2. Drive  513.2 mi

    cheapest
    1. Drive from Hyannis to Buffalocar car 513.2 mi
    9h 5m
    $94–136

  3. Bus

    1. Take the bus from Hyannis Transportation Center to Boston South Busesbus bus Hyannis - South Shore to Logan Airport
    2. Take the bus from Boston to Buffalobus bus Greyhound US0171
    12h 55m
    $112–165

  4. Bus, train

    1. Take the bus from Hyannis to Bostonbus bus Bz 0947 / ...
    2. Take the train from Boston to Buffalo Depew Stationtrain train Lake Shore Limited
    15h 34m
    $276–584

  5. Bus to Boston Logan Airport, fly

    1. Take the bus from Hyannis to Bostonbus bus
    2. Fly from Boston Logan Airport (BOS) to Buffalo Niagara International Airport (BUF)plane plane BOS - BUF
    5h 37m
    $115–704

  6. Bus via Ithaca

    1. Take the bus from Hyannis Transportation Center to Boston South Busesbus bus
    2. Take the bus from Boston to Ithacabus bus
    3. Take the bus from Ithaca to Buffalobus bus
    15h 24m
    $113–165

Hyannis to Buffalo by bus

Calendar7Weekly Buses
Duration12h 55mAverage Duration
Ticket$112Cheapest Price
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Comparing Your Travel Options

Map of how to get from Hyannis to Buffalo.ExpandLaunch map view
  • Distance: 449.8 mi
  • Duration: 5h 12m

What companies run services between Hyannis, MA, USA and Buffalo, NY, USA?

American Airlines, JetBlue Airways, and Cape Air fly from Barnstable Municipal Airport (HYA) to Buffalo Niagara International Airport (BUF) 5 times a day. Alternatively, you can take a bus from Hyannis Transportation Center to Buffalo via Boston, South Station and Boston in around 12h 55m.

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