Charlotte is the most populous city in the U.S. state of North Carolina. Located in the Piedmont, it is the county seat of Mecklenburg County. In 2018, the U.S. Census Bureau estimated the population was 872,498, making it the 16th-most populous city in the United States. The city is the cultural, economic, and transportation center of the Charlotte metropolitan area, whose population ranks 23rd in the U.S., and had a population of 2,569,213, in 2018. The Charlotte metropolitan area is part of a sixteen-county market region or combined statistical area with a 2018 census-estimated population of 2,728,933.