Weirton is a city in Brooke and Hancock counties in the U.S. state of West Virginia. Located primarily in Hancock County, the city lies in the northern portions of the state's Northern Panhandle region. As of the 2010 census, the city's population was 19,746. Weirton is a principal city of the Weirton–Steubenville, WV-OH Metropolitan Statistical Area, which had a 2010 population of 124,454 residents. Additionally, Weirton is part of Greater Pittsburgh, the 20th largest combined statistical area in the United States with a 2016 estimated population of 2,635,228.