Memphis is a city located along the Mississippi River in southwestern Shelby County, Tennessee, United States. The 2018 city population was 650,618, making Memphis the largest city on the Mississippi River, the second most populous city in Tennessee, as well as the 26th largest city in the United States. Greater Memphis is the 42nd largest metropolitan area in the United States, with a population of 1,348,260 in 2017. The city is the anchor of West Tennessee and the greater Mid-South region, which includes portions of neighboring Arkansas, Mississippi, and the Missouri Bootheel. Memphis is the seat of Shelby County, the most populous county in Tennessee. As one of the more historic and culturally significant cities of the southern United States, the city features a wide variety of landscapes and distinct neighborhoods.