Durham is a city in the U.S. state of North Carolina and the county seat of Durham County. Small portions of the city limits extend into Orange County and Wake County. With a population of 283,506 in the 2020 census, Durham is the 4th-most populous city in North Carolina, and the 71st-most populous city in the United States. The city is located in the east-central part of the Piedmont region along the Eno River. Durham is the core of the four-county Durham-Chapel Hill, NC Metropolitan Statistical Area, which had a population of 649,903 at the 2020 census. The Office of Management and Budget also includes Durham as a part of the Raleigh-Durham-Cary, NC Combined Statistical Area, commonly known as the Research Triangle, which had a population of 2,043,867 at the 2020 census.