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About Cape Girardeau

Cape Girardeau is a city in Cape Girardeau County in the U.S. state of Missouri. It is located approximately 115 mi southeast of St. Louis and 175 mi north of Memphis. As of the 2018 United States Census Bureau estimates, the city's population was 39,853, making it the 17th-largest city in Missouri, and the largest city in Southeast Missouri. An emerging college town, it is the home of Southeast Missouri State University.

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