From Holyhead train to Milton Keynes Central. 3 h 6 min £127. From Holyhead train to Birmingham New Street, train to Wolverton Railway Station, then bus to Central Milton Keynes, The Point (Central Milton Keynes The Point K3). 6 h 24 min £87. From Holyhead drive to Milton Keynes. 3 h 56 min £43.