There are 5 ways to get from Hilton Head Island to Great Smoky Mountains National Park by bus, car, train or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Bus, drive  •  15 h 53 min

  1. Take the bus from Beaufort, Sc to Winston Salem, Nc
  2. Take the bus from Winston Salem, Nc to Asheville, Nc
  3. Drive from Asheville, Nc to Great Smoky Mountains National Park

$64 - $148

4 alternative options

Bus, train, drive  •  17 h 36 min

  1. Take the bus from Hwy 278 & Wild Horse to Yemassee 320
  2. Take the train from Yemassee Amtrak to Selma-Smithfield Amtrak
  3. Take the train from Selma-Smithfield Amtrak to Greensboro Galyon Transportation Center
  4. Take the bus from Greensboro, Nc to Winston Salem, Nc
  5. Take the bus from Winston Salem, Nc to Asheville, Nc
  6. Drive from Asheville, Nc to Great Smoky Mountains National Park

$118 - $283

Drive  •  6 h 4 min

  1. Drive from Hilton Head Island to Great Smoky Mountains National Park 371 miles

$35 - $55

Fly from Hilton Head, drive  •  6 h 29 min

  1. Fly from Hilton Head (HHH) to Knoxville (TYS) HHH - TYS
  2. Drive from Knoxville to Great Smoky Mountains National Park

$121 - $591

Bus to Savannah, fly, drive  •  8 h 39 min

  1. Take the bus from Beaufort, Sc to Savannah, Ga
  2. Fly from Savannah (SAV) to Knoxville (TYS) SAV - TYS
  3. Drive from Knoxville to Great Smoky Mountains National Park

$192 - $989

Questions & Answers

The distance between Hilton Head Island and Great Smoky Mountains National Park is 284 miles. The road distance is 371 miles.

Get driving directions

It takes approximately 15 h 53 min to get from Hilton Head Island to Great Smoky Mountains National Park, including transfers.

More details

There is no direct flight from Hilton Head Airport to Knoxville Airport. The quickest flight takes 3 h 31 min and has one stopover.

Search flights

Yes, the driving distance between Hilton Head Island to Great Smoky Mountains National Park is 371 miles. It takes approximately 6 h 4 min to drive from Hilton Head Island to Great Smoky Mountains National Park.

Get driving directions

American Airlines offers flights from Hilton Head Airport to Knoxville Airport.

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There are 1719+ hotels available in Great Smoky Mountains National Park. Prices start at $67 USD per night.

More details

The best way to get from Hilton Head Island to Hilton Head Airport is to line 310 bus which takes 7 min and costs .

More details

Map of how to get from Hilton Head Island to Great Smoky Mountains National Park.
Launch map view
  • Distance: 283.9 miles
  • Duration: 15 h 53 min

What companies run services between Hilton Head Island, SC, USA and Great Smoky Mountains National Park, TN, USA?

There is no direct connection from Hilton Head Island to Great Smoky Mountains National Park. However, you can take the bus to Lowes, take the walk to Beaufort, Sc, take the bus to Winston Salem, Nc, take the bus to Asheville, Nc, then take the drive to Great Smoky Mountains National Park. Alternatively, you can take the bus to Yemassee, take the walk to Yemassee Amtrak, take the train to Selma-Smithfield Amtrak, take the train to Greensboro Galyon Transportation Center, take the walk to Greensboro, Nc, take the bus to Winston Salem, Nc, take the bus to Asheville, Nc, then take the drive to Great Smoky Mountains National Park.

Airlines
American Airlines
Website
aa.com
Flights from Hilton Head to Knoxville via Charlotte
Ave. Duration
4 h 12 min
When
Every day
Estimated price
$110 - $600
Flights from Hilton Head to Knoxville via Charlotte, Reagan Washington
Ave. Duration
6 h 43 min
When
Every day
Estimated price
$140 - $650
Flights from Hilton Head to Knoxville via Charlotte, Chicago O'Hare
Ave. Duration
7 h 35 min
When
Every day
Estimated price
$160 - $700
Flights from Savannah to Knoxville via Charlotte
Ave. Duration
4 h 8 min
When
Every day
Estimated price
$180 - $950
Flights from Savannah to Knoxville via Dallas/Ft.Worth
Ave. Duration
5 h 53 min
When
Every day
Estimated price
$300 - $1,200
Flights from Savannah to Knoxville via Reagan Washington
Ave. Duration
6 h 29 min
When
Every day
Estimated price
$230 - $1,100
Delta
Website
delta.com
Flights from Savannah to Knoxville via Atlanta
Ave. Duration
3 h 25 min
When
Every day
Estimated price
$170 - $950
Flights from Savannah to Knoxville via Detroit
Ave. Duration
4 h 51 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$230 - $1,100
United Airlines
Website
united.com
Flights from Savannah to Knoxville via Washington Dulles
Ave. Duration
4 h 13 min
When
Every day
Estimated price
$240 - $1,100
Flights from Savannah to Knoxville via Chicago O'Hare
Ave. Duration
5 h 47 min
When
Every day
Estimated price
$260 - $1,200
Flights from Savannah to Knoxville via Houston
Ave. Duration
6 h 5 min
When
Every day
Estimated price
$290 - $1,300
Train operators
Amtrak

Amtrak is a rail service that connects the US and three Canadian provinces. Covering 21,000 route miles (34,000km) Amtrak operates more than 300 trains daily. These medium and long distance intercity services operate at speeds of up to 240km/h, to more than 500 destinations. Founded in 1971, it is based in Washington, D.C. and offers four classes of travel: First Class, Sleeper, Business and Coach. Ticket fares are divided into five subclasses: Saver, Value, Flexible, Business and Premium. Amtrak trains are known for their wide seats, plug-in power, big windows and storage capabilities.

Rome2rio's guide to Amtrak
Contact Details
Phone
+1 1-800-872-7245
Website
amtrak.com
Train from Yemassee Amtrak to Selma-Smithfield Amtrak
Ave. Duration
4 h 44 min
Frequency
Once daily
Estimated price
$50 - $130
Website
amtrak.com
Coach Seat
$50 - $75
Flexi Coach Seat
$90 - $130
Business Coach Seat
$90 - $130
Room
$230 - $320
Train from Selma-Smithfield Amtrak to Greensboro Galyon Transportation Center
Ave. Duration
2 h 29 min
Frequency
Once daily
Estimated price
$30 - $70
Website
amtrak.com
Coach Seat
$30 - $45
Flexi Coach Seat
$55 - $80
Business Coach Seat
$45 - $70
Room
$160 - $230
Bus operators
Greyhound USA

Greyhound is a leading bus company based in Dallas, Texas, serving over 3800 destinations across North America, Mexico and Canada. Greyhound carries around 18 million passengers a year who travel 5.4 billion miles (8.6 billion km) a year on their fleet of around 1700 vehicles. For travel flexibility, you can board or get off a Greyhound bus at official Greyhound stations, partner stations and curbside stops. There are around 230 Greyhound stations across the US where you can both catch your bus and buy tickets, that are also available on the official website and via the mobile app.

Rome2rio's guide to Greyhound USA
Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from Beaufort, Sc to Winston Salem, Nc
Ave. Duration
8 h 45 min
Frequency
Hourly
Estimated price
$35 - $85
Website
greyhound.com
Economy
$35 - $55
Flexible
$65 - $85
Bus from Winston Salem, Nc to Asheville, Nc
Ave. Duration
2 h 55 min
Frequency
Every 2 hours
Estimated price
$20 - $50
Website
greyhound.com
Economy
$20 - $30
Flexible
$35 - $50
Bus from Greensboro, Nc to Winston Salem, Nc
Ave. Duration
45 min
Frequency
Hourly
Estimated price
$9 - $20
Website
greyhound.com
Economy
$9 - $14
Flexible
$16 - $20
Bus from Beaufort, Sc to Savannah, Ga
Ave. Duration
55 min
Frequency
Every 30 minutes
Estimated price
$10 - $23
Website
greyhound.com
Economy
$10 - $15
Flexible
$18 - $23
Palmetto Breeze Transit
Website
palmettobreezetransit.com
Bus from Hwy 278 & Wild Horse to Yemassee
Ave. Duration
1 h 41 min
Frequency
Twice daily
Estimated price
$2
Schedules at
palmettobreezetransit.com
Sunway Charters
Phone
+1 704-348-1200
Email
info@sunwaycharters.com
Website
sunwaycharters.com
Bus from Greensboro, Nc to Winston-Salem
Ave. Duration
40 min
Frequency
Twice daily
Schedules at
sunwaycharters.com

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Trips to Great Smoky Mountains National Park